SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hks'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3CE6_D_ADND500_2 (ADENOSYLHOMOCYSTEINA SE)	3hks	EUKARYOTIC TRANSLATION INITIATION FACTOR 5A-2 (Arabidopsis thaliana)	4 / 5	LEU A 116 GLN A 125 THR A 123 LEU A 103	None	1.08A	3ce6D-3hksA: undetectable	3ce6D-3hksA: 13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3M6W_A_SAMA465_0 (RRNA METHYLASE)	3hks	EUKARYOTIC TRANSLATION INITIATION FACTOR 5A-2 (Arabidopsis thaliana)	5 / 12	GLY A 109 GLY A 108 VAL A 101 ASP A 94 VAL A 152	None	1.07A	3m6wA-3hksA: undetectable	3m6wA-3hksA: 14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OF4_B_ACTB313_0 (NITROREDUCTASE)	3hks	EUKARYOTIC TRANSLATION INITIATION FACTOR 5A-2 (Arabidopsis thaliana)	3 / 3	ALA A 151 VAL A 152 GLN A 125	None	0.61A	3of4B-3hksA: undetectable	3of4B-3hksA: 21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ONN_A_ACTA271_0 (PROTEIN SSM1)	3hks	EUKARYOTIC TRANSLATION INITIATION FACTOR 5A-2 (Arabidopsis thaliana)	4 / 5	GLY A 157 LYS A 134 GLU A 154 GLY A 158	None	1.02A	3onnA-3hksA: undetectable	3onnA-3hksA: 20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Z2E_H_TR6H101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B SYMMETRIZED E-SITE DNA)	3hks	EUKARYOTIC TRANSLATION INITIATION FACTOR 5A-2 (Arabidopsis thaliana)	3 / 5	GLY A 158 GLY A 156 GLU A 154	None	0.52A	4z2eA-3hksA: undetectable 4z2eD-3hksA: undetectable	4z2eA-3hksA: 16.12 4z2eD-3hksA: 24.16

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3CE6_D_ADND500_2","ADENOSYLHOMOCYSTEINASE","3hks","EUKARYOTIC TRANSLATION INITIATION FACTOR 5A-2","Arabidopsis thaliana",4,"LEU A 116;GLN A 125;THR A 123;LEU A 103","None","1.08A","3ce6D-3hksA:undetectable","3ce6D-3hksA:13.73"],["3M6W_A_SAMA465_0","RRNA METHYLASE","3hks","EUKARYOTIC TRANSLATION INITIATION FACTOR 5A-2","Arabidopsis thaliana",5,"GLY A 109;GLY A 108;VAL A 101;ASP A  94;VAL A 152","None","1.07A","3m6wA-3hksA:undetectable","3m6wA-3hksA:14.91"],["3OF4_B_ACTB313_0","NITROREDUCTASE","3hks","EUKARYOTIC TRANSLATION INITIATION FACTOR 5A-2","Arabidopsis thaliana",3,"ALA A 151;VAL A 152;GLN A 125","None","0.61A","3of4B-3hksA:undetectable","3of4B-3hksA:21.86"],["3ONN_A_ACTA271_0","PROTEIN SSM1","3hks","EUKARYOTIC TRANSLATION INITIATION FACTOR 5A-2","Arabidopsis thaliana",4,"GLY A 157;LYS A 134;GLU A 154;GLY A 158","None","1.02A","3onnA-3hksA:undetectable","3onnA-3hksA:20.63"],["4Z2E_H_TR6H101_1","DNA GYRASE SUBUNIT A;DNA GYRASE SUBUNIT B;SYMMETRIZED E-SITE DNA","3hks","EUKARYOTIC TRANSLATION INITIATION FACTOR 5A-2","Arabidopsis thaliana",3,"GLY A 158;GLY A 156;GLU A 154","None","0.52A","4z2eA-3hksA:undetectable;4z2eD-3hksA:undetectable","4z2eA-3hksA:16.12;4z2eD-3hksA:24.16"]]