SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hkz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_A_T3A1_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		5 / 12 ILE B1108
ILE B1109
ALA A 299
LEU B1100
PHE A  11
 None
 1.16A 1bsxA-3hkzB:
undetectable		 1bsxA-3hkzB:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_B_T3B2_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		5 / 12 ILE B1108
ILE B1109
ALA A 299
LEU B1100
PHE A  11
 None
 1.17A 1bsxB-3hkzB:
undetectable		 1bsxB-3hkzB:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBS_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE II)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		5 / 12 ILE B 723
ALA B 722
PRO B 701
VAL B 987
TYR B 713
 None
 0.98A 1cbsA-3hkzB:
undetectable		 1cbsA-3hkzB:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_1
(PROTEIN (HIV-1
PROTEASE))		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		5 / 10 LEU B 230
ALA B 268
ASP B 266
ILE B 286
GLY B 273
 None
 1.21A 1d4sA-3hkzB:
undetectable		 1d4sA-3hkzB:
7.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_1
(PROTEIN (HIV-1
PROTEASE))		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		5 / 10 ARG B 751
ALA B 998
ILE A 342
GLY A 440
ILE B 874
 None
 1.09A 1d4yA-3hkzB:
undetectable		 1d4yA-3hkzB:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DGM_A_ADNA375_1
(ADENOSINE KINASE)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
(Sulfolobus
solfataricus) 		5 / 9 ILE A 496
GLY A 497
ASN A 605
LEU A 445
TYR A 502
 None
 1.43A 1dgmA-3hkzA:
undetectable		 1dgmA-3hkzA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_B_NCAB700_0
(EXOTOXIN A)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		4 / 6 GLY B 930
TYR B 962
ALA B 966
GLU B 968
 None
 0.92A 1dmaB-3hkzB:
undetectable		 1dmaB-3hkzB:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_1
(HIV-II PROTEASE)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
(Sulfolobus
solfataricus) 		5 / 12 GLY A 712
ALA A 711
ILE A 665
GLY A 748
ILE A 661
 None
 0.86A 1hshA-3hkzA:
undetectable		 1hshA-3hkzA:
7.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_1
(HIV-II PROTEASE)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
(Sulfolobus
solfataricus) 		5 / 12 GLY A 712
ALA A 711
ILE A 665
GLY A 748
ILE A 661
 None
 0.85A 1hshC-3hkzA:
undetectable		 1hshC-3hkzA:
7.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I6V_C_RFPC1640_1
(DNA-DIRECTED RNA
POLYMERASE)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		5 / 12 LEU B 226
PHE B 253
ASP B 235
ARG B 228
ILE B 262
 None
 1.28A 1i6vC-3hkzB:
16.6		 1i6vC-3hkzB:
29.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ILQ_C_ACAC7_1
(INTERLEUKIN-8
PRECURSOR
INTERLEUKIN-8
RECEPTOR A)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
(Sulfolobus
solfataricus) 		4 / 6 HIS A  89
PHE A  93
ASP A 198
PRO A 204
 None
 0.73A 1ilqA-3hkzA:
undetectable
1ilqC-3hkzA:
undetectable		 1ilqA-3hkzA:
6.21
1ilqC-3hkzA:
1.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		5 / 11 ASP B 571
ASN B 554
ARG B 574
GLY B 556
GLY B 524
 None
 1.47A 1jr1A-3hkzB:
undetectable		 1jr1A-3hkzB:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTX_A_CVIA200_0
(HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR IN QACA
5'REGION)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
(Sulfolobus
solfataricus) 		5 / 12 ILE A 326
TYR A 502
ILE A 503
ALA A 498
ASN A 605
 None
 1.23A 1jtxA-3hkzA:
undetectable		 1jtxA-3hkzA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA154_1
(CALMODULIN)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		4 / 7 MET B1105
LEU A  14
GLU A  18
MET A  22
 None
 1.15A 1linA-3hkzB:
undetectable		 1linA-3hkzB:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_2
(PROTEASE)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		4 / 6 ASP B 907
GLY B 986
PRO B 912
ILE B 909
 None
 0.88A 1n49D-3hkzB:
undetectable		 1n49D-3hkzB:
7.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NH8_A_HISA289_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		4 / 5 ASP B 266
LEU B 233
ALA B 268
LEU B 269
 None
 1.17A 1nh8A-3hkzB:
undetectable		 1nh8A-3hkzB:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
(Sulfolobus
solfataricus) 		5 / 12 ALA A 472
LEU A 418
THR A 348
PRO A 350
PHE A 320
 None
 1.09A 1og5A-3hkzA:
undetectable		 1og5A-3hkzA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA501_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		5 / 12 GLU B  72
GLY B 117
ASP B 388
ILE B 389
GLN B 368
 None
 1.00A 1oltA-3hkzB:
undetectable		 1oltA-3hkzB:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_0
(N,N-DIMETHYLGLYCINE
OXIDASE)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		5 / 12 GLY B 231
PHE B 223
LEU B 315
TYR B 313
PHE B 253
 None
 1.19A 1pj7A-3hkzB:
undetectable		 1pj7A-3hkzB:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		5 / 10 LEU B 792
TYR B 789
VAL B 774
GLY B 812
SER B 836
 None
 1.14A 1pxxA-3hkzB:
undetectable		 1pxxA-3hkzB:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_B_DIFB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		5 / 9 LEU B 792
TYR B 789
VAL B 774
GLY B 812
SER B 836
 None
 1.14A 1pxxB-3hkzB:
undetectable		 1pxxB-3hkzB:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_D_DIFD3701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		5 / 10 LEU B 792
TYR B 789
VAL B 774
GLY B 812
SER B 836
 None
 1.12A 1pxxD-3hkzB:
undetectable		 1pxxD-3hkzB:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_2
(ESTROGEN RECEPTOR
BETA)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		3 / 3 ASP A 720
LEU A 719
HIS B 913
 None
 0.77A 1qknA-3hkzA:
undetectable		 1qknA-3hkzA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		4 / 6 ARG B  86
ASP B  29
ASN B  32
GLU B 158
 None
 1.10A 1rjdA-3hkzB:
undetectable		 1rjdA-3hkzB:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		4 / 6 ARG B  86
ASP B  29
ASN B  32
GLU B 158
 None
 1.09A 1rjdB-3hkzB:
undetectable		 1rjdB-3hkzB:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		4 / 6 ARG B  86
ASP B  29
ASN B  32
GLU B 158
 None
 1.08A 1rjdC-3hkzB:
undetectable		 1rjdC-3hkzB:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB504_1
(YKOF)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		4 / 6 PRO B 120
LEU B 349
ILE B 161
SER B  30
 None
 1.04A 1sbrA-3hkzB:
undetectable
1sbrB-3hkzB:
undetectable		 1sbrA-3hkzB:
10.51
1sbrB-3hkzB:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_A_SAMA302_0
(HYPOTHETICAL PROTEIN
PH0226)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		5 / 12 TYR B 314
ILE B 190
ALA B 168
ILE B 521
HIS B 300
 None
 1.17A 1ve3A-3hkzB:
undetectable		 1ve3A-3hkzB:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_B_SAMB301_0
(HYPOTHETICAL PROTEIN
PH0226)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		5 / 12 TYR B 314
ILE B 190
ALA B 168
ILE B 521
HIS B 300
 None
 1.16A 1ve3B-3hkzB:
undetectable		 1ve3B-3hkzB:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus;
Sulfolobus
solfataricus) 		3 / 3 MET A 646
ASN A 739
GLN B 662
 None
 1.05A 1xoqB-3hkzA:
undetectable		 1xoqB-3hkzA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_2
(PHOSPHOLIPASE A2
HOMOLOG 2)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		5 / 11 LEU B 369
LEU B 384
VAL B 374
GLY B 376
ARG B 377
 None
 0.99A 1y4lB-3hkzB:
undetectable		 1y4lB-3hkzB:
7.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		4 / 8 PRO B 148
LEU B  23
GLY B  22
LEU B 423
 None
 0.95A 1ya4A-3hkzB:
undetectable		 1ya4A-3hkzB:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE509_0
(NAD-DEPENDENT
DEACETYLASE 2)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus;
Sulfolobus
solfataricus) 		4 / 6 LYS B 341
ASP B 336
TYR A 761
ARG B 452
 None
 1.19A 1yc2A-3hkzB:
undetectable
1yc2B-3hkzB:
undetectable
1yc2E-3hkzB:
undetectable		 1yc2A-3hkzB:
12.34
1yc2B-3hkzB:
12.34
1yc2E-3hkzB:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YNN_C_RFPC1120_1
(DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		5 / 12 GLN B 412
ASP B 415
HIS B 425
ARG B 428
PRO B 459
 None
 0.92A 1ynnC-3hkzB:
21.7		 1ynnC-3hkzB:
29.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		4 / 8 SER B 744
ARG B 747
ASN B 741
ASP B 907
 None
 1.23A 1zzuA-3hkzB:
undetectable		 1zzuA-3hkzB:
17.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A69_C_RPTC8001_1
(DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN
RNA POLYMERASE SIGMA
FACTOR RPOD)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		5 / 11 GLN B 412
ASP B 415
HIS B 425
ARG B 428
PRO B 459
 None
 0.88A 2a69C-3hkzB:
20.6
2a69F-3hkzB:
0.0		 2a69C-3hkzB:
30.01
2a69F-3hkzB:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_2
(POL POLYPROTEIN)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
(Sulfolobus
solfataricus) 		3 / 3 ASP A 278
VAL A 273
PRO A 213
 None
 0.73A 2avvA-3hkzA:
2.8		 2avvA-3hkzA:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B60_B_RITB100_1
(GAG-POL POLYPROTEIN)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
(Sulfolobus
solfataricus) 		5 / 12 GLY A 712
ALA A 711
ILE A 665
GLY A 748
ILE A 661
 None
 0.74A 2b60A-3hkzA:
undetectable		 2b60A-3hkzA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B60_B_RITB100_2
(GAG-POL POLYPROTEIN)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
(Sulfolobus
solfataricus) 		5 / 11 GLY A 712
ALA A 711
ILE A 665
GLY A 748
ILE A 661
 None
 0.78A 2b60B-3hkzA:
undetectable		 2b60B-3hkzA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BLA_A_CP6A302_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		5 / 11 ILE B 394
ALA B 397
ASN B 155
SER B 157
ILE B 153
 None
 1.13A 2blaA-3hkzB:
undetectable		 2blaA-3hkzB:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_B_SPMB1433_1
(NITROALKANE OXIDASE)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		5 / 11 GLN B 991
ALA B 676
SER B 421
LEU B 420
ASP B 415
 None
 1.47A 2c12B-3hkzB:
undetectable		 2c12B-3hkzB:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FR3_A_REAA300_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
2)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		5 / 12 ILE B 723
ALA B 722
PRO B 701
VAL B 987
TYR B 713
 None
 0.96A 2fr3A-3hkzB:
undetectable		 2fr3A-3hkzB:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HKK_A_ALEA300_1
(CARBONIC ANHYDRASE 2)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		4 / 6 ASN B 911
HIS B 913
ASN B 733
ILE B 892
 None
 1.16A 2hkkA-3hkzB:
undetectable		 2hkkA-3hkzB:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_1
(HIV-1 PROTEASE)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
(Sulfolobus
solfataricus) 		5 / 12 GLY A 712
ALA A 711
ILE A 665
GLY A 748
ILE A 661
 None
 0.86A 2hs1A-3hkzA:
undetectable		 2hs1A-3hkzA:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_2
(HIV-1 PROTEASE)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
(Sulfolobus
solfataricus) 		5 / 12 GLY A 712
ALA A 711
ILE A 665
GLY A 748
ILE A 661
 None
 0.90A 2hs1B-3hkzA:
undetectable		 2hs1B-3hkzA:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4L_A_TPVA403_1
(PROTEASE)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		5 / 12 LEU B 230
ALA B 268
ASP B 266
ILE B 286
GLY B 273
 None
 1.26A 2o4lA-3hkzB:
undetectable		 2o4lA-3hkzB:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA802_1
(TRANSPORTER)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		4 / 6 ILE B 580
ARG B 545
ARG B 544
PHE B 604
 None
 1.09A 2q72A-3hkzB:
undetectable		 2q72A-3hkzB:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBL_A_CAMA517_0
(CYTOCHROME P450-CAM)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus;
Sulfolobus
solfataricus) 		4 / 7 LEU B1001
THR A 324
VAL B 887
ASP B 876
 None
 0.87A 2qblA-3hkzB:
undetectable		 2qblA-3hkzB:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBM_A_CAMA517_0
(CYTOCHROME P450-CAM)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
(Sulfolobus
solfataricus) 		4 / 8 THR A 731
VAL A 511
THR A 510
VAL A 639
 None
 0.85A 2qbmA-3hkzA:
undetectable		 2qbmA-3hkzA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1103_0
(FERROCHELATASE)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		4 / 8 ARG B 197
SER B 432
VAL B 404
GLY B 405
 None
 1.10A 2qd5B-3hkzB:
undetectable		 2qd5B-3hkzB:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_NCAA493_0
(CHORISMATE SYNTHASE)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
(Sulfolobus
solfataricus) 		5 / 11 ALA A 506
THR A 510
ILE A 552
ILE A 603
ALA A 602
 None
 0.79A 2qhfA-3hkzA:
undetectable		 2qhfA-3hkzA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKF_A_AB1A501_1
(PROTEASE RETROPEPSIN)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
(Sulfolobus
solfataricus) 		5 / 12 GLY A 712
ALA A 711
ILE A 665
GLY A 748
ILE A 661
 None
 0.91A 2rkfA-3hkzA:
undetectable		 2rkfA-3hkzA:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKF_A_AB1A501_2
(PROTEASE RETROPEPSIN)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
(Sulfolobus
solfataricus) 		5 / 12 GLY A 712
ALA A 711
ILE A 665
GLY A 748
ILE A 661
 None
 0.88A 2rkfB-3hkzA:
2.7		 2rkfB-3hkzA:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKG_B_AB1B501_1
(PROTEASE RETROPEPSIN)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
(Sulfolobus
solfataricus) 		5 / 12 GLY A 712
ALA A 711
ILE A 665
GLY A 748
ILE A 661
 None
 0.84A 2rkgA-3hkzA:
3.1		 2rkgA-3hkzA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKG_B_AB1B501_2
(PROTEASE RETROPEPSIN)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
(Sulfolobus
solfataricus) 		5 / 12 GLY A 712
ALA A 711
ILE A 665
GLY A 748
ILE A 661
 None
 0.83A 2rkgB-3hkzA:
3.1		 2rkgB-3hkzA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_A_ECNA1409_1
(CYTOCHROME P450 130)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		5 / 12 ASP B 834
GLY B 807
GLY B 806
THR B 839
LEU B 792
 None
 0.99A 2uvnA-3hkzB:
undetectable		 2uvnA-3hkzB:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_G_RBFG200_1
(DODECIN)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		4 / 8 ARG B1004
ARG B1027
THR B1013
GLN B1010
 None
 1.37A 2vxaF-3hkzB:
0.0
2vxaG-3hkzB:
0.0
2vxaI-3hkzB:
0.0		 2vxaF-3hkzB:
5.44
2vxaG-3hkzB:
5.44
2vxaI-3hkzB:
5.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_B_TOPB1189_1
(DIHYDROFOLATE
REDUCTASE)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		5 / 10 ILE B 121
ALA B 126
PHE B  34
ILE B  63
LEU B  96
 None
 1.26A 2w3aB-3hkzB:
undetectable		 2w3aB-3hkzB:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1352_1
(PROSTAGLANDIN
REDUCTASE 2)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		4 / 7 TYR B 240
TYR B 529
ASN B 250
TYR B 317
 None
 1.12A 2w98A-3hkzB:
undetectable
2w98B-3hkzB:
undetectable		 2w98A-3hkzB:
16.18
2w98B-3hkzB:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_D_TOPD1158_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
(Sulfolobus
solfataricus) 		5 / 10 ILE A 588
LEU A 627
LEU A 612
ILE A 611
PHE A 560
 None
 1.19A 2w9sD-3hkzA:
undetectable		 2w9sD-3hkzA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0P_A_ADNA1607_1
(ALCALIGIN
BIOSYNTHESIS PROTEIN)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		4 / 8 ILE B 655
ASN B 661
ALA B 929
GLU B 926
 None
 0.93A 2x0pA-3hkzB:
undetectable		 2x0pA-3hkzB:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_X_CPFX1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		4 / 4 ARG B 525
GLY B 524
GLU B 482
SER B 320
 None
 1.38A 2xctS-3hkzB:
undetectable
2xctU-3hkzB:
undetectable		 2xctS-3hkzB:
21.32
2xctU-3hkzB:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		4 / 6 LEU B 353
ILE B 394
ILE B  80
LEU B 123
 None
 0.92A 2xkwB-3hkzB:
undetectable		 2xkwB-3hkzB:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		5 / 11 ILE B1101
GLY B1068
PHE A  72
PRO B1111
ILE B1067
 None
 1.14A 2y7kA-3hkzB:
undetectable		 2y7kA-3hkzB:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		4 / 5 ALA B 289
GLN B 290
ILE B 293
ARG B 308
 None
 1.41A 2z0aA-3hkzB:
undetectable		 2z0aA-3hkzB:
5.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_A_VDYA6178_1
(VITAMIN D
HYDROXYLASE)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
(Sulfolobus
solfataricus) 		5 / 11 THR A 514
ILE A 524
LEU A 509
ILE A 552
VAL A 530
 None
 1.24A 3a51A-3hkzA:
1.9		 3a51A-3hkzA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_2
(PHOSPHOLIPASE A2)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		4 / 5 ILE B 647
SER B 644
PRO B 645
PHE B 945
 None
 1.38A 3bjwC-3hkzB:
undetectable		 3bjwC-3hkzB:
7.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFL_A_5CHA693_1
(LACTOTRANSFERRIN)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		4 / 4 THR B 176
VAL B 322
GLY B 208
THR B 209
 None
 1.06A 3cflA-3hkzB:
undetectable		 3cflA-3hkzB:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CO4_A_GCSA401_1
(CHITINASE)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		3 / 3 GLU B 629
HIS B 637
HIS A 768
 None
 0.89A 3co4A-3hkzB:
undetectable		 3co4A-3hkzB:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus;
Sulfolobus
solfataricus) 		5 / 9 PHE A 457
VAL B 887
GLY B 875
ARG A 444
GLY A 459
 None
 1.40A 3csjB-3hkzA:
undetectable		 3csjB-3hkzA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_2
(PROTEASE)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		5 / 9 ARG B 751
ALA B 998
ILE A 342
GLY A 440
ILE B 874
 None
 1.08A 3el4B-3hkzB:
undetectable		 3el4B-3hkzB:
7.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		5 / 10 TYR B 984
ILE B 909
VAL B 988
GLY B 927
VAL B 904
 None
 1.29A 3em0A-3hkzB:
undetectable		 3em0A-3hkzB:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		5 / 12 ILE B  80
LEU B  87
ARG B  71
VAL B  70
ARG B  86
 None
 1.24A 3fpjB-3hkzB:
undetectable		 3fpjB-3hkzB:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_1
(REPRESSOR PROTEIN
MPHR(A))		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
DNA-DIRECTED RNA
POLYMERASE, SUBUNIT
G (RPOG)
(Sulfolobus
solfataricus;
Sulfolobus
solfataricus;
Sulfolobus
solfataricus) 		4 / 7 LYS G  24
TYR A 507
HIS B 913
ALA A 733
 None
 1.43A 3frqB-3hkzG:
undetectable		 3frqB-3hkzG:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_C_ADNC438_2
(ADENOSYLHOMOCYSTEINA
SE)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		4 / 5 THR B 651
THR B 417
HIS B 994
HIS B 425
 None
 1.30A 3g1uC-3hkzB:
undetectable		 3g1uC-3hkzB:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		3 / 3 ILE B 655
PHE B 456
HIS B 660
 None
 0.70A 3h0aA-3hkzB:
undetectable		 3h0aA-3hkzB:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
DNA-DIRECTED RNA
POLYMERASE, SUBUNIT
G (RPOG)
(Sulfolobus
solfataricus;
Sulfolobus
solfataricus) 		4 / 8 ILE A 539
GLY G  73
SER G  85
ASN G  88
 None
 0.75A 3lslA-3hkzA:
undetectable
3lslD-3hkzA:
undetectable		 3lslA-3hkzA:
14.79
3lslD-3hkzA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID801_0
(GLUTAMATE RECEPTOR 2)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
DNA-DIRECTED RNA
POLYMERASE, SUBUNIT
G (RPOG)
(Sulfolobus
solfataricus;
Sulfolobus
solfataricus) 		4 / 8 SER G  85
ASN G  88
ILE A 539
GLY G  73
 None
 0.69A 3lslA-3hkzG:
undetectable
3lslD-3hkzG:
undetectable		 3lslA-3hkzG:
17.92
3lslD-3hkzG:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		4 / 4 GLY B 479
GLU B 552
ASP B  33
ASP B 571
 None
 1.30A 3mb5A-3hkzB:
undetectable		 3mb5A-3hkzB:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_B_VORB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		5 / 11 LEU B 123
SER B 125
ILE B 153
ALA B  94
ALA B  85
 None
 1.09A 3mdtB-3hkzB:
undetectable		 3mdtB-3hkzB:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		4 / 8 SER B 744
ARG B 747
ASN B 741
ASP B 907
 None
 1.10A 3n62B-3hkzB:
undetectable		 3n62B-3hkzB:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU4_B_478B401_2
(PROTEASE)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
(Sulfolobus
solfataricus) 		5 / 9 GLY A 712
ALA A 711
ILE A 665
GLY A 748
ILE A 661
 None
 0.84A 3nu4B-3hkzA:
undetectable		 3nu4B-3hkzA:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_2
(CYCLIN-DEPENDENT
KINASE 8)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
(Sulfolobus
solfataricus) 		4 / 7 LEU A 411
VAL A 339
VAL A 466
LEU A 441
 None
 0.75A 3rgfA-3hkzA:
undetectable		 3rgfA-3hkzA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_2
(CYCLIN-DEPENDENT
KINASE 8)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
(Sulfolobus
solfataricus) 		4 / 7 LEU A 509
VAL A 551
LEU A 612
MET A 628
 None
 0.77A 3rgfA-3hkzA:
undetectable		 3rgfA-3hkzA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_2
(PROTEASE)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
(Sulfolobus
solfataricus) 		5 / 10 GLY A 712
ALA A 711
ILE A 665
GLY A 748
ILE A 661
 None
 0.83A 3s43B-3hkzA:
undetectable		 3s43B-3hkzA:
8.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S45_B_478B201_2
(PROTEASE)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
(Sulfolobus
solfataricus) 		5 / 11 GLY A 712
ALA A 711
ILE A 665
GLY A 748
ILE A 661
 None
 0.96A 3s45B-3hkzA:
2.6		 3s45B-3hkzA:
7.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_1
(HIV-1 PROTEASE)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		5 / 11 ARG B 751
ALA B 998
ILE A 342
GLY A 440
ILE B 874
 None
 0.97A 3spkA-3hkzB:
undetectable		 3spkA-3hkzB:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		5 / 12 HIS B 913
GLY A 505
SER A 504
ALA A 499
ALA A 498
 None
 1.22A 3sueB-3hkzB:
undetectable		 3sueB-3hkzB:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYE_B_YTZB902_1
(DIHYDROPTEROATE
SYNTHASE)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		3 / 3 PHE A 638
LYS B 980
SER B 981
 None
 1.38A 3tyeB-3hkzA:
undetectable		 3tyeB-3hkzA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A201_2
(POL POLYPROTEIN)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		5 / 9 ARG B 751
ALA B 998
ILE A 342
GLY A 440
ILE B 874
 None
 1.14A 3u7sB-3hkzB:
undetectable		 3u7sB-3hkzB:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEO_A_ACRA1001_2
(ALPHA-GLUCOSIDASE)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		4 / 6 ILE B 655
TRP B  11
ILE B   7
TRP B 643
 None
 0.91A 3weoA-3hkzB:
undetectable		 3weoA-3hkzB:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A81_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		5 / 12 ILE B 161
GLY B 347
ASP B 348
ILE B 476
VAL B 575
 None
 1.13A 4a81A-3hkzB:
undetectable		 4a81A-3hkzB:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA503_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
(Sulfolobus
solfataricus) 		4 / 6 ARG A 380
ILE A 407
VAL A 365
LEU A 388
 None
 1.03A 4em2A-3hkzA:
undetectable		 4em2A-3hkzA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F93_B_SANB3004_1
(U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		4 / 8 GLU B 761
ASN B  89
GLY B 156
SER B 157
 None
 0.86A 4f93B-3hkzB:
undetectable		 4f93B-3hkzB:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_E_D16E301_1
(THYMIDYLATE SYNTHASE)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
(Sulfolobus
solfataricus) 		5 / 12 SER A 322
ILE A 343
TRP A 372
GLY A 338
PHE A 443
 None
 1.38A 4foxE-3hkzA:
undetectable		 4foxE-3hkzA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K36_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		5 / 12 GLU B 482
ASN B 523
VAL B 172
ILE B 189
LEU B 315
 None
 1.31A 4k36A-3hkzB:
undetectable		 4k36A-3hkzB:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		4 / 7 ARG B 407
PRO B 215
SER B 213
VAL B 200
 None
 1.39A 4kmmA-3hkzB:
undetectable		 4kmmA-3hkzB:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMU_C_RFPC1401_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		5 / 12 GLN B 412
ASP B 415
HIS B 425
PRO B 459
ASN B 463
 None
 0.88A 4kmuC-3hkzB:
16.6		 4kmuC-3hkzB:
27.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA2)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		4 / 6 ARG B 525
GLY B 302
ASP B 307
GLY B 195
 None
 0.97A 4koeA-3hkzB:
undetectable
4koeB-3hkzB:
undetectable
4koeC-3hkzB:
undetectable		 4koeA-3hkzB:
19.36
4koeB-3hkzB:
19.36
4koeC-3hkzB:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA4)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		4 / 7 ARG B 525
GLY B 302
ASP B 307
GLY B 195
 None
 0.95A 4koeA-3hkzB:
undetectable
4koeB-3hkzB:
undetectable
4koeD-3hkzB:
undetectable		 4koeA-3hkzB:
19.36
4koeB-3hkzB:
19.36
4koeD-3hkzB:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		4 / 5 TYR B 338
GLN B 449
ASP B 334
ASP B 175
 None
 1.43A 4qtuB-3hkzB:
undetectable		 4qtuB-3hkzB:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		5 / 12 LEU B  39
ILE B 394
ILE B  43
ILE B 116
PHE B 358
 None
 1.23A 4rp8C-3hkzB:
undetectable		 4rp8C-3hkzB:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
(Sulfolobus
solfataricus) 		3 / 3 SER A 287
ASP A  46
ASP A 234
 None
 0.79A 4uckA-3hkzA:
undetectable		 4uckA-3hkzA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB102_1
(CHROMOBOX PROTEIN
HOMOLOG 7)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		3 / 3 LYS B 519
ARG B 171
VAL B 172
 None
 0.83A 4x3uA-3hkzB:
undetectable
4x3uB-3hkzB:
undetectable		 4x3uA-3hkzB:
4.25
4x3uB-3hkzB:
4.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		4 / 7 LYS B 309
LYS B 311
TYR B 313
TYR B 317
 None
 1.18A 4yv5B-3hkzB:
undetectable		 4yv5B-3hkzB:
7.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		4 / 6 GLY B 302
ASP B 307
GLY B 195
ARG B 525
 None
 0.96A 4z53A-3hkzB:
undetectable
4z53B-3hkzB:
undetectable		 4z53A-3hkzB:
22.01
4z53B-3hkzB:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ARF_A_SAMA1002_0
(N-LYSINE
METHYLTRANSFERASE
SMYD2)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus;
Sulfolobus
solfataricus) 		5 / 12 GLY B1068
HIS A  71
CYH A  61
ASN B1073
HIS B1082
 None
ZN  A1001 (-3.2A)
ZN  A1001 ( 3.9A)
None
None
 1.32A 5arfA-3hkzB:
0.0		 5arfA-3hkzB:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		4 / 6 SER A 321
ARG B 840
GLY B 842
GLU B 843
 None
 0.93A 5btaA-3hkzA:
undetectable
5btaB-3hkzA:
undetectable
5btaC-3hkzA:
undetectable		 5btaA-3hkzA:
21.20
5btaB-3hkzA:
16.74
5btaC-3hkzA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		4 / 6 SER A 321
ARG B 840
GLY B 842
GLU B 843
 None
 0.88A 5btcA-3hkzA:
undetectable
5btcB-3hkzA:
undetectable
5btcC-3hkzA:
undetectable		 5btcA-3hkzA:
21.20
5btcB-3hkzA:
16.74
5btcC-3hkzA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_F_GFNF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		4 / 7 SER A 321
ARG B 840
GLY B 842
GLU B 843
 None
 0.85A 5btfA-3hkzA:
undetectable
5btfB-3hkzA:
undetectable
5btfC-3hkzA:
undetectable		 5btfA-3hkzA:
21.20
5btfB-3hkzA:
16.74
5btfC-3hkzA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_2
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
13
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
(Sulfolobus
solfataricus) 		3 / 3 GLU Y  76
TRP A 125
ASN A 119
 None
 1.14A 5dv4A-3hkzY:
undetectable		 5dv4A-3hkzY:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_S_BEZS801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		4 / 6 PHE B 350
HIS B  27
MET B 122
LEU B 349
 None
 1.33A 5dzke-3hkzB:
undetectable
5dzks-3hkzB:
undetectable		 5dzke-3hkzB:
12.57
5dzks-3hkzB:
0.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_1
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		4 / 4 ASP B  33
GLY B 347
ASP B 348
ASP B 571
 None
 1.22A 5e72A-3hkzB:
undetectable		 5e72A-3hkzB:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_F_FK5F201_1
(FK506-BINDING
PROTEIN 1)		 3hkz DNA-DIRECTED RNA
POLYMERASE, SUBUNIT
G (RPOG)
(Sulfolobus
solfataricus) 		5 / 12 TYR G  92
PHE G  40
VAL G  57
ILE G  59
ILE G  46
 None
 1.12A 5hw8B-3hkzG:
undetectable
5hw8F-3hkzG:
undetectable
5hw8G-3hkzG:
undetectable		 5hw8B-3hkzG:
20.86
5hw8F-3hkzG:
20.86
5hw8G-3hkzG:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		4 / 6 PRO B 246
ALA B 187
LEU B 205
TYR B 314
 None
 1.07A 5igiA-3hkzB:
undetectable		 5igiA-3hkzB:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		4 / 5 PRO B1016
HIS B 841
LEU A 411
TYR A 377
 None
 1.12A 5igjA-3hkzB:
undetectable		 5igjA-3hkzB:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		4 / 7 GLY A 817
SER A 816
LEU A 823
GLU B1032
 None
 0.83A 5izfA-3hkzA:
undetectable		 5izfA-3hkzA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_J_Z80J401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		5 / 12 ILE B 480
VAL B 485
THR B 488
GLU B 491
ILE B 549
 None
 1.18A 5lg3J-3hkzB:
undetectable		 5lg3J-3hkzB:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND3_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		5 / 12 VAL B 940
ASP B 941
LEU A 648
ARG B 881
PRO B 656
 None
 0.96A 5nd3B-3hkzB:
undetectable		 5nd3B-3hkzB:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZ0_A_ZLDA301_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus;
Sulfolobus
solfataricus) 		5 / 12 TYR B 984
THR A 645
VAL B 726
ASN A 723
LEU A 719
 None
 1.36A 5nz0A-3hkzB:
0.4		 5nz0A-3hkzB:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA604_0
(THIOCYANATE
DEHYDROGENASE)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		3 / 3 HIS B 693
HIS B 994
HIS B 995
 None
 0.98A 5oexA-3hkzB:
undetectable		 5oexA-3hkzB:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8H_B_478B401_1
(PROTEASE)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
(Sulfolobus
solfataricus) 		5 / 12 GLY A 712
ALA A 711
ILE A 665
GLY A 748
ILE A 661
 None
 0.87A 5t8hA-3hkzA:
undetectable		 5t8hA-3hkzA:
8.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8H_B_478B401_2
(PROTEASE)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
(Sulfolobus
solfataricus) 		5 / 12 GLY A 712
ALA A 711
ILE A 665
GLY A 748
ILE A 661
 None
 0.91A 5t8hB-3hkzA:
undetectable		 5t8hB-3hkzA:
8.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAC_C_RFPC3001_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		5 / 12 GLN B 412
ASP B 415
HIS B 425
ARG B 428
PRO B 459
 None
 0.78A 5uacC-3hkzB:
15.0		 5uacC-3hkzB:
27.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_0
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		5 / 12 GLY B 585
LEU B 633
VAL B 582
HIS B 639
LEU B 640
 None
 1.19A 5ubbA-3hkzB:
undetectable		 5ubbA-3hkzB:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UH6_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		5 / 12 GLN B 412
ASP B 415
HIS B 425
ARG B 428
ASN B 463
 None
 0.93A 5uh6C-3hkzB:
21.8		 5uh6C-3hkzB:
29.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		5 / 12 GLN B 412
HIS B 425
ARG B 428
PRO B 459
ASN B 463
 None
 0.81A 5uhbC-3hkzB:
21.7		 5uhbC-3hkzB:
29.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		5 / 12 GLN B 412
HIS B 425
ARG B 428
PRO B 459
ASN B 463
 None
 0.92A 5uhcC-3hkzB:
21.7		 5uhcC-3hkzB:
29.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHD_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		5 / 12 GLN B 412
HIS B 425
ARG B 428
PRO B 459
ASN B 463
 None
 0.97A 5uhdC-3hkzB:
10.7		 5uhdC-3hkzB:
29.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHG_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		6 / 12 GLN B 412
ASP B 415
HIS B 425
ARG B 428
PRO B 459
ASN B 463
 None
 0.80A 5uhgC-3hkzB:
21.8		 5uhgC-3hkzB:
29.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_1
(RIBOFLAVIN LYASE)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		5 / 12 ALA B  94
GLY B 347
ALA B 351
SER B 125
VAL B  35
 None
 0.96A 5w4zA-3hkzB:
undetectable		 5w4zA-3hkzB:
4.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_2
(RIBOFLAVIN LYASE)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		4 / 5 ASN B1052
GLN A 468
ASP A 319
ARG B1004
 None
 1.33A 5w4zA-3hkzB:
undetectable		 5w4zA-3hkzB:
4.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_B_RBFB502_1
(RIBOFLAVIN LYASE)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		5 / 12 ALA B  94
GLY B 347
ALA B 351
SER B 125
VAL B  35
 None
 0.99A 5w4zB-3hkzB:
undetectable		 5w4zB-3hkzB:
4.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		5 / 12 GLN B 699
GLY B 930
LEU B 724
GLY B 986
GLY B 927
 None
 1.00A 5wyqB-3hkzB:
undetectable		 5wyqB-3hkzB:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_2
(CYTOCHROME P450 2C9)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
(Sulfolobus
solfataricus) 		3 / 3 LEU A 696
VAL A 672
ASP A 673
 None
 0.56A 5x23A-3hkzA:
undetectable		 5x23A-3hkzA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
DNA-DIRECTED RNA
POLYMERASE, SUBUNIT
G (RPOG)
(Sulfolobus
solfataricus) 		3 / 3 TYR A 507
LEU G  23
ASP G  41
 None
 0.83A 5zv2B-3hkzA:
undetectable		 5zv2B-3hkzA:
6.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		3 / 3 HIS B 994
HIS B 693
ARG B 870
 None
 0.91A 6b58A-3hkzB:
undetectable		 6b58A-3hkzB:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BER_A_DVAA2_0
(E(DVA)DP(DGL)(DHI)(D
PR)N(DAL)(DPR))		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus;
Sulfolobus
solfataricus) 		3 / 3 GLU B1103
ASP A 233
PRO A 221
 None
 0.70A 6berA-3hkzB:
undetectable		 6berA-3hkzB:
1.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CCV_C_RFPC1205_1
(-)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		5 / 12 GLN B 412
ASP B 415
HIS B 425
ARG B 428
PRO B 459
 None
 1.12A 6ccvC-3hkzB:
22.0		 6ccvC-3hkzB:
29.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA826_0
(GEPHYRIN)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		3 / 3 HIS B 639
ARG B 545
ILE B 581
 None
 0.43A 6fgdA-3hkzB:
undetectable		 6fgdA-3hkzB:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		 3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
(Sulfolobus
solfataricus) 		4 / 6 ARG B 427
ALA B 707
THR B 705
ALA B 652
 None
 1.14A 6ma6A-3hkzB:
undetectable		 6ma6A-3hkzB:
4.90