SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hl0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)		 3hl0 MALEYLACETATE
REDUCTASE
(Agrobacterium
fabrum) 		5 / 10 GLY A 121
LEU A 220
TYR A 151
THR A 228
GLY A 227
 None
 1.16A 1kvlA-3hl0A:
undetectable		 1kvlA-3hl0A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)		 3hl0 MALEYLACETATE
REDUCTASE
(Agrobacterium
fabrum) 		5 / 10 GLY A 121
TYR A 151
TYR A 119
THR A 228
GLY A 227
 None
 1.30A 1kvlA-3hl0A:
undetectable		 1kvlA-3hl0A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))		 3hl0 MALEYLACETATE
REDUCTASE
(Agrobacterium
fabrum) 		4 / 4 HIS A 263
ALA A 344
PHE A 345
GLY A 347
 None
 1.00A 1mj2B-3hl0A:
undetectable		 1mj2B-3hl0A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_1
(PROTEIN (METHIONINE
REPRESSOR))		 3hl0 MALEYLACETATE
REDUCTASE
(Agrobacterium
fabrum) 		4 / 4 HIS A 263
ALA A 344
PHE A 345
GLY A 347
 None
 1.01A 1mj2D-3hl0A:
undetectable		 1mj2D-3hl0A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)		 3hl0 MALEYLACETATE
REDUCTASE
(Agrobacterium
fabrum) 		4 / 4 HIS A 263
ALA A 344
PHE A 345
GLY A 347
 None
 0.98A 1mjoB-3hl0A:
undetectable		 1mjoB-3hl0A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)		 3hl0 MALEYLACETATE
REDUCTASE
(Agrobacterium
fabrum) 		4 / 4 HIS A 263
ALA A 344
PHE A 345
GLY A 347
 None
 1.01A 1mjoA-3hl0A:
undetectable		 1mjoA-3hl0A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)		 3hl0 MALEYLACETATE
REDUCTASE
(Agrobacterium
fabrum) 		4 / 4 HIS A 263
ALA A 344
PHE A 345
GLY A 347
 None
 0.99A 1mjoD-3hl0A:
undetectable		 1mjoD-3hl0A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3hl0 MALEYLACETATE
REDUCTASE
(Agrobacterium
fabrum) 		5 / 12 LEU A 298
LEU A 169
ARG A 297
ALA A 202
ALA A 215
 None
 1.17A 2bm9D-3hl0A:
2.5		 2bm9D-3hl0A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3hl0 MALEYLACETATE
REDUCTASE
(Agrobacterium
fabrum) 		5 / 12 GLY A  95
GLY A 168
ASN A 170
ALA A 171
HIS A 174
 NAD  A 402 (-3.2A)
None
NAD  A 402 ( 4.4A)
None
None
 0.95A 2bm9F-3hl0A:
2.4		 2bm9F-3hl0A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3hl0 MALEYLACETATE
REDUCTASE
(Agrobacterium
fabrum) 		5 / 12 GLY A 168
ASN A 170
ALA A 171
HIS A 174
ALA A 175
 None
NAD  A 402 ( 4.4A)
None
None
None
 1.04A 2bm9F-3hl0A:
2.4		 2bm9F-3hl0A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_A_DZPA2001_1
(SERUM ALBUMIN)		 3hl0 MALEYLACETATE
REDUCTASE
(Agrobacterium
fabrum) 		5 / 12 ILE A  27
CYH A  88
LEU A  92
VAL A  37
LEU A  50
 None
 0.95A 2bxfA-3hl0A:
undetectable		 2bxfA-3hl0A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		 3hl0 MALEYLACETATE
REDUCTASE
(Agrobacterium
fabrum) 		5 / 12 ILE A  27
CYH A  88
LEU A  92
VAL A  37
LEU A  50
 None
 0.96A 2bxfB-3hl0A:
undetectable		 2bxfB-3hl0A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_A_ECNA1409_1
(CYTOCHROME P450 130)		 3hl0 MALEYLACETATE
REDUCTASE
(Agrobacterium
fabrum) 		5 / 12 ASP A  46
THR A  97
GLY A  94
GLY A  95
THR A 118
 None
None
NAD  A 402 (-3.3A)
NAD  A 402 (-3.2A)
NAD  A 402 (-2.8A)
 1.13A 2uvnA-3hl0A:
undetectable		 2uvnA-3hl0A:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)		 3hl0 MALEYLACETATE
REDUCTASE
(Agrobacterium
fabrum) 		5 / 12 ALA A 110
ALA A  86
GLY A 101
ILE A 104
LEU A  92
 None
 1.06A 2x1lB-3hl0A:
undetectable		 2x1lB-3hl0A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_0
(N,N-DIMETHYLTRANSFER
ASE)		 3hl0 MALEYLACETATE
REDUCTASE
(Agrobacterium
fabrum) 		5 / 12 GLY A 288
HIS A 263
MET A 172
PHE A 292
LEU A 203
 None
 1.23A 3bxoA-3hl0A:
2.7		 3bxoA-3hl0A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB2_A_IBPA3960_1
(LACTOTRANSFERRIN)		 3hl0 MALEYLACETATE
REDUCTASE
(Agrobacterium
fabrum) 		4 / 4 GLY A 227
VAL A 124
GLY A  95
THR A  97
 None
None
NAD  A 402 (-3.2A)
None
 0.81A 3ib2A-3hl0A:
undetectable		 3ib2A-3hl0A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB1_0
(INVASIN IPAD)		 3hl0 MALEYLACETATE
REDUCTASE
(Agrobacterium
fabrum) 		4 / 7 ILE A 332
LEU A 237
LEU A 260
VAL A 309
 None
 0.84A 3r9vA-3hl0A:
undetectable
3r9vB-3hl0A:
undetectable		 3r9vA-3hl0A:
21.87
3r9vB-3hl0A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEG_A_DAHA416_1
(PHENYLALANYL-TRNA
SYNTHETASE,
MITOCHONDRIAL)		 3hl0 MALEYLACETATE
REDUCTASE
(Agrobacterium
fabrum) 		5 / 12 GLU A 269
GLY A 290
GLY A 284
ALA A 280
GLY A 288
 None
 0.81A 3tegA-3hl0A:
undetectable		 3tegA-3hl0A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TZF_B_08DB280_1
(7,8-DIHYDROPTEROATE
SYNTHASE)		 3hl0 MALEYLACETATE
REDUCTASE
(Agrobacterium
fabrum) 		4 / 8 THR A 125
PRO A 146
GLY A  99
SER A  91
 NAD  A 402 (-2.7A)
None
None
None
 1.04A 3tzfB-3hl0A:
2.4		 3tzfB-3hl0A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B53_B_ACTB1445_0
(IG GAMMA-4 CHAIN C
REGION)		 3hl0 MALEYLACETATE
REDUCTASE
(Agrobacterium
fabrum) 		3 / 3 GLU A  48
GLY A  45
SER A  63
 None
 0.65A 4b53B-3hl0A:
undetectable		 4b53B-3hl0A:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA305_1
(TYROSINASE)		 3hl0 MALEYLACETATE
REDUCTASE
(Agrobacterium
fabrum) 		4 / 7 HIS A 174
HIS A 253
HIS A 257
ALA A 173
 None
NAD  A 402 (-3.6A)
None
None
 0.92A 4p6sA-3hl0A:
undetectable		 4p6sA-3hl0A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3hl0 MALEYLACETATE
REDUCTASE
(Agrobacterium
fabrum) 		4 / 8 LEU A 304
THR A 264
LEU A 241
LEU A 245
 None
 0.75A 4z90F-3hl0A:
undetectable
4z90G-3hl0A:
undetectable
4z90H-3hl0A:
undetectable
4z90I-3hl0A:
undetectable
4z90J-3hl0A:
undetectable		 4z90F-3hl0A:
21.41
4z90G-3hl0A:
21.41
4z90H-3hl0A:
21.41
4z90I-3hl0A:
21.41
4z90J-3hl0A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)		 3hl0 MALEYLACETATE
REDUCTASE
(Agrobacterium
fabrum) 		4 / 7 VAL A  23
ILE A  27
VAL A  90
ILE A 115
 None
 0.73A 5bmvC-3hl0A:
2.7		 5bmvC-3hl0A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		 3hl0 MALEYLACETATE
REDUCTASE
(Agrobacterium
fabrum) 		4 / 7 HIS A 174
HIS A 253
HIS A 257
ALA A 173
 None
NAD  A 402 (-3.6A)
None
None
 0.88A 5i3aA-3hl0A:
undetectable		 5i3aA-3hl0A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		 3hl0 MALEYLACETATE
REDUCTASE
(Agrobacterium
fabrum) 		4 / 7 HIS A 174
HIS A 253
HIS A 257
ALA A 173
 None
NAD  A 402 (-3.6A)
None
None
 0.86A 5i3aB-3hl0A:
undetectable		 5i3aB-3hl0A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		 3hl0 MALEYLACETATE
REDUCTASE
(Agrobacterium
fabrum) 		4 / 7 HIS A 174
HIS A 253
HIS A 257
ALA A 173
 None
NAD  A 402 (-3.6A)
None
None
 0.90A 5i3bA-3hl0A:
undetectable		 5i3bA-3hl0A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		 3hl0 MALEYLACETATE
REDUCTASE
(Agrobacterium
fabrum) 		4 / 5 HIS A 253
HIS A 257
HIS A 174
ALA A 120
 NAD  A 402 (-3.6A)
None
None
NAD  A 402 (-3.5A)
 1.35A 5i3bB-3hl0A:
undetectable		 5i3bB-3hl0A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_G_SAMG501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 3hl0 MALEYLACETATE
REDUCTASE
(Agrobacterium
fabrum) 		6 / 11 LEU A 100
GLU A  72
SER A  39
LEU A  38
GLU A  79
ALA A  77
 None
 1.45A 5o96G-3hl0A:
undetectable		 5o96G-3hl0A:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0C_D_TA1D502_1
(TUBULIN BETA CHAIN)		 3hl0 MALEYLACETATE
REDUCTASE
(Agrobacterium
fabrum) 		5 / 12 LEU A 341
ALA A 344
LEU A 241
ARG A 330
GLY A 288
 None
 0.83A 6b0cD-3hl0A:
2.8		 6b0cD-3hl0A:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_1
()		 3hl0 MALEYLACETATE
REDUCTASE
(Agrobacterium
fabrum) 		4 / 8 LEU A 179
LEU A 279
LEU A 225
GLY A 222
 None
 0.90A 6ce2A-3hl0A:
1.1		 6ce2A-3hl0A:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		 3hl0 MALEYLACETATE
REDUCTASE
(Agrobacterium
fabrum) 		5 / 12 GLY A 234
THR A 138
GLY A 129
HIS A 174
ASN A 185
 None
 1.03A 6gngA-3hl0A:
3.8		 6gngA-3hl0A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		 3hl0 MALEYLACETATE
REDUCTASE
(Agrobacterium
fabrum) 		4 / 6 SER A  91
ALA A 105
THR A 108
ALA A  86
 None
 1.17A 6ma6A-3hl0A:
undetectable		 6ma6A-3hl0A:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_0
(PEPTIDYLPROLYL
ISOMERASE)		 3hl0 MALEYLACETATE
REDUCTASE
(Agrobacterium
fabrum) 		4 / 4 ASP A  46
ILE A 115
PRO A 116
LEU A  92
 None
 1.41A 6mkeB-3hl0A:
undetectable		 6mkeB-3hl0A:
13.04