SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hl4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_ACTA600_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 3hl4 CHOLINE-PHOSPHATE
CYTIDYLYLTRANSFERASE
A
(Rattus
norvegicus) 		4 / 5 LEU A 153
VAL A 181
TYR A 182
THR A 152
 None
 1.19A 1nw3A-3hl4A:
undetectable		 1nw3A-3hl4A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)		 3hl4 CHOLINE-PHOSPHATE
CYTIDYLYLTRANSFERASE
A
(Rattus
norvegicus) 		4 / 8 PHE A  85
LEU A 108
VAL A 142
LEU A  96
 CDC  A 237 (-4.4A)
None
None
None
 0.83A 2w98B-3hl4A:
2.6		 2w98B-3hl4A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DA7_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3hl4 CHOLINE-PHOSPHATE
CYTIDYLYLTRANSFERASE
A
(Rattus
norvegicus) 		5 / 10 GLY A 111
ALA A  45
VAL A 145
GLU A 144
VAL A 112
 None
 1.29A 4da7A-3hl4A:
undetectable		 4da7A-3hl4A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_B_VORB590_1
(14-ALPHA STEROL
DEMETHYLASE)		 3hl4 CHOLINE-PHOSPHATE
CYTIDYLYLTRANSFERASE
A
(Rattus
norvegicus) 		4 / 7 TYR A 173
TYR A 182
ALA A 149
ILE A  84
 CDC  A 237 (-3.7A)
None
None
CDC  A 237 (-4.2A)
 0.78A 4uymB-3hl4A:
undetectable		 4uymB-3hl4A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 3hl4 CHOLINE-PHOSPHATE
CYTIDYLYLTRANSFERASE
A
(Rattus
norvegicus) 		4 / 7 GLY A  83
PHE A  85
HIS A  92
SER A 201
 CDC  A 237 (-3.3A)
CDC  A 237 (-4.4A)
CDC  A 237 (-4.3A)
None
 0.77A 6jnhA-3hl4A:
10.6		 6jnhA-3hl4A:
21.85