SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hlk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)		 3hlk ACYL-COENZYME A
THIOESTERASE 2,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 GLY A 230
TYR A 252
TYR A 255
THR A 228
GLY A 229
 None
 1.41A 1kvlA-3hlkA:
undetectable		 1kvlA-3hlkA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_0
(HYPOTHETICAL PROTEIN
LMO1582)		 3hlk ACYL-COENZYME A
THIOESTERASE 2,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ALA A 313
GLY A 292
ASN A 317
VAL A 223
GLY A 289
 None
 1.05A 2f8lA-3hlkA:
undetectable		 2f8lA-3hlkA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_1
(ANDROGEN RECEPTOR)		 3hlk ACYL-COENZYME A
THIOESTERASE 2,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 299
GLY A 292
VAL A 320
ALA A 304
LEU A 307
 None
 1.11A 2oz7A-3hlkA:
undetectable		 2oz7A-3hlkA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_G_CPFG1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 3hlk ACYL-COENZYME A
THIOESTERASE 2,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ARG A 205
GLY A 204
SER A 279
 None
 0.62A 2xctB-3hlkA:
2.9		 2xctB-3hlkA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6W_A_SAMA465_0
(RRNA METHYLASE)		 3hlk ACYL-COENZYME A
THIOESTERASE 2,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ALA A 454
GLY A 421
GLY A 447
VAL A 458
ASP A 459
 None
 0.92A 3m6wA-3hlkA:
2.5		 3m6wA-3hlkA:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_B_CL6B506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3hlk ACYL-COENZYME A
THIOESTERASE 2,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A  96
VAL A  94
ALA A 116
GLU A 121
ALA A  65
 None
 0.92A 3mdvB-3hlkA:
undetectable		 3mdvB-3hlkA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA452_1
(CYTOCHROME P450
164A2)		 3hlk ACYL-COENZYME A
THIOESTERASE 2,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 PRO A 213
LEU A 212
LEU A 210
LEU A 277
LEU A 290
 None
 0.94A 3r9cA-3hlkA:
undetectable		 3r9cA-3hlkA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_C_BEZC1_0
(HEME-BINDING PROTEIN
HUTZ)		 3hlk ACYL-COENZYME A
THIOESTERASE 2,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 ARG A 158
TYR A 235
PHE A 429
LEU A 155
 None
 1.47A 3tgvC-3hlkA:
undetectable		 3tgvC-3hlkA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TPX_E_ACTE204_0
(E3 UBIQUITIN-PROTEIN
LIGASE MDM2)		 3hlk ACYL-COENZYME A
THIOESTERASE 2,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 LYS A 150
PRO A 151
LEU A 152
 None
 0.86A 3tpxE-3hlkA:
undetectable		 3tpxE-3hlkA:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG8_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3hlk ACYL-COENZYME A
THIOESTERASE 2,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 TYR A 252
GLU A 268
TYR A 329
 None
 1.01A 3ug8A-3hlkA:
undetectable		 3ug8A-3hlkA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1004_1
(HEMOLYTIC LECTIN
CEL-III)		 3hlk ACYL-COENZYME A
THIOESTERASE 2,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 GLU A 332
GLY A 331
TYR A 329
GLU A 268
 None
 1.14A 3w9tA-3hlkA:
undetectable		 3w9tA-3hlkA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB502_1
(HEMOLYTIC LECTIN
CEL-III)		 3hlk ACYL-COENZYME A
THIOESTERASE 2,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 GLU A 332
GLY A 331
TYR A 329
GLU A 268
 None
 1.14A 3w9tB-3hlkA:
undetectable		 3w9tB-3hlkA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1002_1
(HEMOLYTIC LECTIN
CEL-III)		 3hlk ACYL-COENZYME A
THIOESTERASE 2,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 GLU A 332
GLY A 331
TYR A 329
GLU A 268
 None
 1.15A 3w9tC-3hlkA:
undetectable		 3w9tC-3hlkA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD512_1
(HEMOLYTIC LECTIN
CEL-III)		 3hlk ACYL-COENZYME A
THIOESTERASE 2,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 GLU A 332
GLY A 331
TYR A 329
GLU A 268
 None
 1.14A 3w9tD-3hlkA:
undetectable		 3w9tD-3hlkA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE502_1
(HEMOLYTIC LECTIN
CEL-III)		 3hlk ACYL-COENZYME A
THIOESTERASE 2,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 GLU A 332
GLY A 331
TYR A 329
GLU A 268
 None
 1.13A 3w9tE-3hlkA:
undetectable		 3w9tE-3hlkA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF503_1
(HEMOLYTIC LECTIN
CEL-III)		 3hlk ACYL-COENZYME A
THIOESTERASE 2,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 GLU A 332
GLY A 331
TYR A 329
GLU A 268
 None
 1.15A 3w9tF-3hlkA:
undetectable		 3w9tF-3hlkA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG502_1
(HEMOLYTIC LECTIN
CEL-III)		 3hlk ACYL-COENZYME A
THIOESTERASE 2,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 GLU A 332
GLY A 331
TYR A 329
GLU A 268
 None
 1.13A 3w9tG-3hlkA:
undetectable		 3w9tG-3hlkA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IOM_A_FOLA608_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 3hlk ACYL-COENZYME A
THIOESTERASE 2,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ALA A 246
PRO A 220
LEU A 277
LEU A 210
 None
 0.92A 4iomA-3hlkA:
undetectable		 4iomA-3hlkA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JJK_A_FOLA601_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 3hlk ACYL-COENZYME A
THIOESTERASE 2,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 ALA A 246
PRO A 220
LEU A 277
LEU A 210
 None
 0.93A 4jjkA-3hlkA:
undetectable		 4jjkA-3hlkA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3hlk ACYL-COENZYME A
THIOESTERASE 2,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 LEU A 277
TYR A 276
VAL A 288
LEU A 212
 None
 1.00A 4l1xA-3hlkA:
undetectable		 4l1xA-3hlkA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_D_SAMD401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 3hlk ACYL-COENZYME A
THIOESTERASE 2,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLY A 297
GLY A 296
THR A 228
LEU A 290
PHE A 380
 None
 0.94A 4pghD-3hlkA:
2.5		 4pghD-3hlkA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_C_MTXC201_1
(DIHYDROFOLATE
REDUCTASE)		 3hlk ACYL-COENZYME A
THIOESTERASE 2,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 ILE A 424
ASP A 388
SER A 435
ARG A 433
LEU A 431
 None
 1.21A 4qi9C-3hlkA:
2.4		 4qi9C-3hlkA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_2
(THYROXINE-BINDING
GLOBULIN)		 3hlk ACYL-COENZYME A
THIOESTERASE 2,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 LEU A 155
ARG A 154
ARG A 158
 None
 0.96A 4yiaB-3hlkA:
undetectable		 4yiaB-3hlkA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_A_PAUA602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 3hlk ACYL-COENZYME A
THIOESTERASE 2,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 GLY A 227
ARG A 236
GLY A 292
TYR A 235
 None
 1.00A 5e26A-3hlkA:
undetectable
5e26B-3hlkA:
undetectable		 5e26A-3hlkA:
21.48
5e26B-3hlkA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_B_PAUB601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 3hlk ACYL-COENZYME A
THIOESTERASE 2,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 7 TYR A 235
GLU A 425
GLY A 227
ARG A 236
GLY A 292
 None
 1.42A 5e26A-3hlkA:
undetectable
5e26B-3hlkA:
undetectable		 5e26A-3hlkA:
21.48
5e26B-3hlkA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_C_PAUC602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 3hlk ACYL-COENZYME A
THIOESTERASE 2,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 7 GLU A 425
GLY A 227
ARG A 236
GLY A 292
TYR A 235
 None
 1.41A 5e26C-3hlkA:
undetectable
5e26D-3hlkA:
undetectable		 5e26C-3hlkA:
21.48
5e26D-3hlkA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKV_A_ASDA602_1
(AROMATASE)		 3hlk ACYL-COENZYME A
THIOESTERASE 2,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 424
ALA A 456
ASP A 459
LEU A 240
LEU A 464
 None
 1.20A 5jkvA-3hlkA:
undetectable		 5jkvA-3hlkA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IE8_A_CHDA201_0
(REGULATORY PROTEIN)		 3hlk ACYL-COENZYME A
THIOESTERASE 2,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 142
ALA A 127
CYH A  75
ASP A 123
LEU A 122
 None
 1.02A 6ie8A-3hlkA:
undetectable		 6ie8A-3hlkA:
18.82