SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hlm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_B_SAMB2401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 3hlm ASPARTATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Mus
musculus) 		5 / 12 LEU A 358
GLY A 218
GLY A 379
ILE A 374
LEU A 394
 None
 1.04A 1p91B-3hlmA:
3.2		 1p91B-3hlmA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_P_CHDP4271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 3hlm ASPARTATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Mus
musculus) 		4 / 7 ARG A 337
LYS A 338
LEU A 341
GLN A 342
 None
 0.89A 1v55P-3hlmA:
undetectable
1v55W-3hlmA:
undetectable		 1v55P-3hlmA:
20.64
1v55W-3hlmA:
8.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3hlm ASPARTATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Mus
musculus) 		4 / 7 ARG A 337
LYS A 338
LEU A 341
GLN A 342
 None
 0.83A 2eijP-3hlmA:
undetectable
2eijW-3hlmA:
undetectable		 2eijP-3hlmA:
20.64
2eijW-3hlmA:
8.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 3hlm ASPARTATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Mus
musculus) 		4 / 6 LEU A 207
LYS A 236
GLN A 225
ILE A 229
 None
 1.07A 2jn3A-3hlmA:
undetectable		 2jn3A-3hlmA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OD9_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 3hlm ASPARTATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Mus
musculus) 		3 / 3 PHE A 291
PHE A 241
PHE A 239
 None
 0.87A 2od9A-3hlmA:
0.6		 2od9A-3hlmA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7K_A_TESA304_1
(ANDROGEN RECEPTOR)		 3hlm ASPARTATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Mus
musculus) 		5 / 12 MET A  60
VAL A 400
MET A 402
LEU A 421
THR A 414
 None
 1.44A 2q7kA-3hlmA:
undetectable		 2q7kA-3hlmA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQG_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 3hlm ASPARTATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Mus
musculus) 		3 / 3 PHE A 291
PHE A 241
PHE A 239
 None
 0.87A 2qqgA-3hlmA:
0.6		 2qqgA-3hlmA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3hlm ASPARTATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Mus
musculus) 		4 / 7 ARG A 337
LYS A 338
LEU A 341
GLN A 342
 None
 0.76A 2zxwC-3hlmA:
undetectable
2zxwJ-3hlmA:
undetectable		 2zxwC-3hlmA:
20.64
2zxwJ-3hlmA:
8.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX94_0
(PROTEIN S100-B)		 3hlm ASPARTATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Mus
musculus) 		3 / 3 PHE A 241
CYH A 274
PHE A 291
 None
 1.14A 3cr5X-3hlmA:
0.1		 3cr5X-3hlmA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P73_A_ACTA275_0
(MHC RFP-Y CLASS I
ALPHA CHAIN)		 3hlm ASPARTATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Mus
musculus) 		3 / 3 ILE A 265
VAL A 120
ARG A 125
 None
 0.72A 3p73A-3hlmA:
undetectable		 3p73A-3hlmA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_A_9PLA501_1
(CYTOCHROME P450 2A6)		 3hlm ASPARTATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Mus
musculus) 		5 / 10 PHE A 241
PHE A 291
ALA A 137
ILE A 168
PHE A 169
 None
 1.12A 3t3qA-3hlmA:
undetectable		 3t3qA-3hlmA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_B_9PLB501_1
(CYTOCHROME P450 2A6)		 3hlm ASPARTATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Mus
musculus) 		5 / 10 PHE A 241
PHE A 291
ALA A 137
ILE A 168
PHE A 169
 None
 1.16A 3t3qB-3hlmA:
undetectable		 3t3qB-3hlmA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_C_9PLC501_1
(CYTOCHROME P450 2A6)		 3hlm ASPARTATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Mus
musculus) 		5 / 10 PHE A 241
PHE A 291
ALA A 137
ILE A 168
PHE A 169
 None
 1.16A 3t3qC-3hlmA:
undetectable		 3t3qC-3hlmA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_D_9PLD501_1
(CYTOCHROME P450 2A6)		 3hlm ASPARTATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Mus
musculus) 		5 / 10 PHE A 241
PHE A 291
ALA A 137
ILE A 168
PHE A 169
 None
 1.15A 3t3qD-3hlmA:
undetectable		 3t3qD-3hlmA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 3hlm ASPARTATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Mus
musculus) 		4 / 6 ALA A 113
ALA A 290
LEU A 273
THR A 292
 None
 0.95A 4dtzA-3hlmA:
undetectable		 4dtzA-3hlmA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		 3hlm ASPARTATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Mus
musculus) 		4 / 6 VAL A 400
LEU A 358
ILE A 425
ALA A 424
 None
 0.55A 4zf8A-3hlmA:
undetectable		 4zf8A-3hlmA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3hlm ASPARTATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Mus
musculus) 		4 / 5 TYR A 246
GLY A  65
TYR A 284
GLY A 285
 LLP  A 279 ( 4.4A)
GOL  A   1 ( 4.6A)
LLP  A 279 ( 4.6A)
None
 0.92A 5ayfA-3hlmA:
undetectable		 5ayfA-3hlmA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_A_SALA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3hlm ASPARTATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Mus
musculus) 		4 / 8 VAL A 129
TYR A 316
GLY A 136
ALA A 137
 None
 0.68A 5f1aA-3hlmA:
undetectable		 5f1aA-3hlmA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_B_SALB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3hlm ASPARTATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Mus
musculus) 		4 / 7 VAL A 129
TYR A 316
GLY A 136
ALA A 137
 None
 0.66A 5f1aB-3hlmA:
undetectable		 5f1aB-3hlmA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_F_RBFF201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 3hlm ASPARTATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Mus
musculus) 		4 / 7 VAL A  80
TYR A  75
GLU A 343
SER A  79
 None
GOL  A 431 (-3.5A)
None
None
 1.32A 5umwA-3hlmA:
undetectable
5umwF-3hlmA:
undetectable		 5umwA-3hlmA:
11.62
5umwF-3hlmA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_0
(STIE PROTEIN)		 3hlm ASPARTATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Mus
musculus) 		5 / 12 GLY A 406
GLY A 385
ILE A 408
VAL A 391
LEU A 394
 None
 0.99A 6ectA-3hlmA:
undetectable		 6ectA-3hlmA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_0
(STIE PROTEIN)		 3hlm ASPARTATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Mus
musculus) 		5 / 12 GLY A 406
GLY A 385
ILE A 408
VAL A 391
LEU A 394
 None
 0.98A 6ecxA-3hlmA:
undetectable		 6ecxA-3hlmA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3hlm ASPARTATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Mus
musculus) 		4 / 8 ASP A 183
ARG A 180
ASP A 197
GLU A 196
 None
 1.11A 6mn4A-3hlmA:
undetectable		 6mn4A-3hlmA:
21.29