SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hlt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_C_ESTC353_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 3hlt HDHD2
(Homo
sapiens) 		5 / 12 VAL A 216
GLY A 217
GLY A 212
PHE A 185
VAL A  10
 None
 1.14A 1fduC-3hltA:
undetectable		 1fduC-3hltA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7V_A_SAMA992_0
(METHYLORNITHINE
SYNTHASE PYLB)		 3hlt HDHD2
(Homo
sapiens) 		5 / 12 THR A 225
GLY A 203
GLN A  29
VAL A  25
ALA A  24
 None
 1.20A 3t7vA-3hltA:
undetectable		 3t7vA-3hltA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA503_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 3hlt HDHD2
(Homo
sapiens) 		4 / 6 ARG A  80
ILE A 143
VAL A 114
LEU A  92
 None
 1.08A 4em2A-3hltA:
undetectable		 4em2A-3hltA:
22.83