SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hly'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A28_B_STRB2_1
(PROGESTERONE
RECEPTOR)		 3hly FLAVODOXIN-LIKE
DOMAIN
(Synechococcus
elongatus) 		5 / 12 LEU A 361
LEU A 370
GLN A 343
LEU A 332
THR A 319
 None
 1.27A 1a28B-3hlyA:
undetectable		 1a28B-3hlyA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3009_0
(BETA-CARBONIC
ANHYDRASE)		 3hly FLAVODOXIN-LIKE
DOMAIN
(Synechococcus
elongatus) 		4 / 5 GLY A 399
LEU A 402
THR A 403
VAL A 263
 None
 0.98A 1ekjF-3hlyA:
2.5
1ekjG-3hlyA:
2.5		 1ekjF-3hlyA:
21.43
1ekjG-3hlyA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX8_A_RTLA1163_0
(BETA-LACTOGLOBULIN)		 3hly FLAVODOXIN-LIKE
DOMAIN
(Synechococcus
elongatus) 		5 / 9 LEU A 268
LEU A 317
GLU A 356
ILE A 335
VAL A 300
 None
 1.45A 1gx8A-3hlyA:
undetectable		 1gx8A-3hlyA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_B_TACB1888_1
(ELONGATION FACTOR
EF-TU)		 3hly FLAVODOXIN-LIKE
DOMAIN
(Synechococcus
elongatus) 		4 / 5 SER A 350
ASP A 355
PRO A 320
SER A 274
 None
 1.39A 2hdnA-3hlyA:
undetectable
2hdnB-3hlyA:
5.9
2hdnD-3hlyA:
2.5		 2hdnA-3hlyA:
10.56
2hdnB-3hlyA:
17.56
2hdnD-3hlyA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3hly FLAVODOXIN-LIKE
DOMAIN
(Synechococcus
elongatus) 		4 / 5 PRO A 383
VAL A 379
THR A 396
GLY A 395
 None
 0.92A 3elzB-3hlyA:
undetectable		 3elzB-3hlyA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3M_A_DLUA398_1
(PFV INTEGRASE)		 3hly FLAVODOXIN-LIKE
DOMAIN
(Synechococcus
elongatus) 		4 / 8 ASP A 349
ASP A 355
GLY A 353
PRO A 357
 None
 0.85A 3s3mA-3hlyA:
undetectable		 3s3mA-3hlyA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		 3hly FLAVODOXIN-LIKE
DOMAIN
(Synechococcus
elongatus) 		6 / 9 ASP A 275
PRO A 320
TYR A 267
GLY A 272
SER A 278
GLY A 318
 None
 1.40A 4mm5A-3hlyA:
undetectable		 4mm5A-3hlyA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		 3hly FLAVODOXIN-LIKE
DOMAIN
(Synechococcus
elongatus) 		6 / 9 ASP A 275
PRO A 320
TYR A 267
GLY A 272
SER A 278
GLY A 318
 None
 1.41A 4mmbA-3hlyA:
undetectable		 4mmbA-3hlyA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA603_1
(TRANSPORTER)		 3hly FLAVODOXIN-LIKE
DOMAIN
(Synechococcus
elongatus) 		5 / 10 ASP A 275
TYR A 267
GLY A 272
SER A 278
GLY A 318
 None
 1.37A 4mmcA-3hlyA:
undetectable		 4mmcA-3hlyA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_A_29QA603_1
(TRANSPORTER)		 3hly FLAVODOXIN-LIKE
DOMAIN
(Synechococcus
elongatus) 		5 / 9 ASP A 275
TYR A 267
GLY A 272
SER A 278
GLY A 318
 None
 1.35A 4mmeA-3hlyA:
undetectable		 4mmeA-3hlyA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJ4_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3hly FLAVODOXIN-LIKE
DOMAIN
(Synechococcus
elongatus) 		4 / 8 SER A 350
LEU A 268
LEU A 297
VAL A 328
 None
 0.81A 4oj4A-3hlyA:
undetectable		 4oj4A-3hlyA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 3hly FLAVODOXIN-LIKE
DOMAIN
(Synechococcus
elongatus) 		5 / 12 GLY A 346
LEU A 370
GLY A 314
ILE A 315
GLY A 284
 None
 0.87A 5d4uC-3hlyA:
3.3		 5d4uC-3hlyA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 3hly FLAVODOXIN-LIKE
DOMAIN
(Synechococcus
elongatus) 		5 / 12 GLY A 346
LEU A 370
GLY A 314
ILE A 315
GLY A 284
 None
 0.86A 5d4uD-3hlyA:
3.3		 5d4uD-3hlyA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_1
(ESTROGEN RECEPTOR)		 3hly FLAVODOXIN-LIKE
DOMAIN
(Synechococcus
elongatus) 		5 / 12 THR A 372
LEU A 370
ALA A 344
ILE A 281
GLY A 395
 None
 0.90A 5gs4A-3hlyA:
undetectable		 5gs4A-3hlyA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_C_ROCC101_1
(PROTEASE PR5-SQV)		 3hly FLAVODOXIN-LIKE
DOMAIN
(Synechococcus
elongatus) 		5 / 9 ILE A 377
GLY A 346
ILE A 315
THR A 319
PRO A 320
 None
 1.26A 5kr2C-3hlyA:
undetectable		 5kr2C-3hlyA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_B_EY4B500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3hly FLAVODOXIN-LIKE
DOMAIN
(Synechococcus
elongatus) 		4 / 6 GLN A 400
TRP A 401
ALA A 373
THR A 372
 None
 1.03A 6cduB-3hlyA:
undetectable
6cduC-3hlyA:
undetectable		 6cduB-3hlyA:
17.43
6cduC-3hlyA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 3hly FLAVODOXIN-LIKE
DOMAIN
(Synechococcus
elongatus) 		5 / 9 ILE A 358
GLY A 318
LEU A 317
GLY A 395
ARG A 378
 None
 1.34A 6nm4B-3hlyA:
undetectable		 6nm4B-3hlyA:
20.81