SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hlz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_D_DVAD8_0
(GRAMICIDIN A)		 3hlz UNCHARACTERIZED
PROTEIN BT_1490
(Bacteroides
thetaiotaomicron) 		3 / 3 TRP A  21
VAL A  38
TRP A  39
 None
 1.47A 1gmkC-3hlzA:
undetectable
1gmkD-3hlzA:
undetectable		 1gmkC-3hlzA:
4.84
1gmkD-3hlzA:
4.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 3hlz UNCHARACTERIZED
PROTEIN BT_1490
(Bacteroides
thetaiotaomicron) 		3 / 3 TYR A  17
GLU A  23
THR A 221
 None
 0.98A 2y7hB-3hlzA:
undetectable		 2y7hB-3hlzA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3hlz UNCHARACTERIZED
PROTEIN BT_1490
(Bacteroides
thetaiotaomicron) 		5 / 12 PHE A  13
ALA A 131
THR A 100
ASN A 104
GLY A 103
 None
 1.38A 3aodC-3hlzA:
undetectable		 3aodC-3hlzA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_1
(N,N-DIMETHYLTRANSFER
ASE)		 3hlz UNCHARACTERIZED
PROTEIN BT_1490
(Bacteroides
thetaiotaomicron) 		3 / 3 TYR A  54
GLU A  62
ASP A  67
 None
 0.85A 3bxoA-3hlzA:
undetectable		 3bxoA-3hlzA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_1
(N,N-DIMETHYLTRANSFER
ASE)		 3hlz UNCHARACTERIZED
PROTEIN BT_1490
(Bacteroides
thetaiotaomicron) 		3 / 3 TYR A  54
GLU A  62
ASP A  67
 None
 0.78A 3bxoB-3hlzA:
3.7		 3bxoB-3hlzA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_A_SUZA201_1
(TRANSTHYRETIN)		 3hlz UNCHARACTERIZED
PROTEIN BT_1490
(Bacteroides
thetaiotaomicron) 		4 / 7 LEU A  32
SER A 110
THR A 112
SER A  95
 None
 0.88A 4ikjA-3hlzA:
undetectable
4ikjB-3hlzA:
undetectable		 4ikjA-3hlzA:
18.39
4ikjB-3hlzA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_B_SUZB201_1
(TRANSTHYRETIN)		 3hlz UNCHARACTERIZED
PROTEIN BT_1490
(Bacteroides
thetaiotaomicron) 		4 / 7 SER A  95
LEU A  32
SER A 110
THR A 112
 None
 0.85A 4ikkA-3hlzA:
undetectable
4ikkB-3hlzA:
undetectable		 4ikkA-3hlzA:
18.39
4ikkB-3hlzA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 3hlz UNCHARACTERIZED
PROTEIN BT_1490
(Bacteroides
thetaiotaomicron) 		3 / 3 LYS A 181
ASN A 256
ASP A 178
 None
 0.84A 4o1eA-3hlzA:
undetectable		 4o1eA-3hlzA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_2_BEZ2801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 3hlz UNCHARACTERIZED
PROTEIN BT_1490
(Bacteroides
thetaiotaomicron) 		4 / 4 LEU A 222
ARG A 132
ILE A 223
ILE A   7
 None
 1.19A 5dzk2-3hlzA:
undetectable
5dzkM-3hlzA:
undetectable
5dzkN-3hlzA:
undetectable		 5dzk2-3hlzA:
1.35
5dzkM-3hlzA:
22.47
5dzkN-3hlzA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_4_BEZ4801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3hlz UNCHARACTERIZED
PROTEIN BT_1490
(Bacteroides
thetaiotaomicron) 		4 / 5 LEU A 142
ARG A 146
ILE A 143
ILE A   7
 None
 1.00A 5dzk4-3hlzA:
undetectable
5dzkg-3hlzA:
undetectable
5dzkm-3hlzA:
undetectable
5dzkn-3hlzA:
undetectable		 5dzk4-3hlzA:
1.35
5dzkg-3hlzA:
23.51
5dzkm-3hlzA:
22.47
5dzkn-3hlzA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_V_BEZV801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 3hlz UNCHARACTERIZED
PROTEIN BT_1490
(Bacteroides
thetaiotaomicron) 		4 / 4 ILE A 223
ILE A   7
ARG A 132
LEU A 142
 None
 1.06A 5dzkh-3hlzA:
undetectable
5dzkn-3hlzA:
undetectable
5dzkv-3hlzA:
undetectable		 5dzkh-3hlzA:
22.47
5dzkn-3hlzA:
22.47
5dzkv-3hlzA:
1.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_V_BEZV801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 3hlz UNCHARACTERIZED
PROTEIN BT_1490
(Bacteroides
thetaiotaomicron) 		4 / 4 ILE A 223
ILE A   7
ARG A 132
LEU A 222
 None
 1.08A 5dzkh-3hlzA:
undetectable
5dzkn-3hlzA:
undetectable
5dzkv-3hlzA:
undetectable		 5dzkh-3hlzA:
22.47
5dzkn-3hlzA:
22.47
5dzkv-3hlzA:
1.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_0
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 3hlz UNCHARACTERIZED
PROTEIN BT_1490
(Bacteroides
thetaiotaomicron) 		5 / 12 ILE A  74
PHE A 107
ILE A  59
ILE A  45
ALA A  47
 None
 1.01A 5e72A-3hlzA:
undetectable		 5e72A-3hlzA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_2
(CDL2.3A)		 3hlz UNCHARACTERIZED
PROTEIN BT_1490
(Bacteroides
thetaiotaomicron) 		4 / 8 ILE A 239
PRO A 241
LEU A 179
ILE A 182
 ACT  A 273 (-4.9A)
None
None
None
 0.99A 5ieoA-3hlzA:
undetectable		 5ieoA-3hlzA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_ACTA405_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3hlz UNCHARACTERIZED
PROTEIN BT_1490
(Bacteroides
thetaiotaomicron) 		4 / 6 ARG A 132
PRO A   9
ARG A 146
ILE A 143
 None
 1.47A 6ef6A-3hlzA:
1.8		 6ef6A-3hlzA:
20.73