SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hm4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1121_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 3hm4 CHEMOTAXIS PROTEIN
CHEX
(Desulfovibrio
alaskensis) 		4 / 5 SER A  60
VAL A 150
SER A  46
VAL A  48
 None
None
None
UNL  A 156 (-4.0A)
 1.30A 2j9cA-3hm4A:
undetectable
2j9cB-3hm4A:
1.6
2j9cC-3hm4A:
undetectable		 2j9cA-3hm4A:
23.72
2j9cB-3hm4A:
23.72
2j9cC-3hm4A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KOT_B_ANWB99_0
(PROTEIN S100-A13)		 3hm4 CHEMOTAXIS PROTEIN
CHEX
(Desulfovibrio
alaskensis) 		4 / 8 VAL A  61
THR A  62
PHE A  63
THR A  64
 None
GOL  A 157 ( 4.4A)
None
None
 1.27A 2kotB-3hm4A:
undetectable		 2kotB-3hm4A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6F_C_010C6_0
(INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE
N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE)		 3hm4 CHEMOTAXIS PROTEIN
CHEX
(Desulfovibrio
alaskensis) 		3 / 3 ASN A  56
LEU A 154
HIS A  54
 None
 0.55A 2q6fB-3hm4A:
undetectable		 2q6fB-3hm4A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_A_SVRA508_2
(PHOSPHOLIPASE A2)		 3hm4 CHEMOTAXIS PROTEIN
CHEX
(Desulfovibrio
alaskensis) 		5 / 9 VAL A  94
VAL A  91
GLY A  92
PRO A 118
GLY A 100
 None
 1.13A 3bjwG-3hm4A:
undetectable		 3bjwG-3hm4A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_3
(PHOSPHOLIPASE A2)		 3hm4 CHEMOTAXIS PROTEIN
CHEX
(Desulfovibrio
alaskensis) 		4 / 5 VAL A  49
VAL A  48
THR A  16
THR A 117
 UNL  A 156 (-4.2A)
UNL  A 156 (-4.0A)
None
None
 1.24A 3bjwG-3hm4A:
undetectable		 3bjwG-3hm4A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZV_A_AZMA263_1
(CARBONIC ANHYDRASE
13)		 3hm4 CHEMOTAXIS PROTEIN
CHEX
(Desulfovibrio
alaskensis) 		5 / 12 VAL A  61
PHE A  63
LEU A  20
VAL A  19
VAL A  71
 None
 1.05A 3czvA-3hm4A:
undetectable
3czvB-3hm4A:
undetectable		 3czvA-3hm4A:
23.08
3czvB-3hm4A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZV_A_AZMA263_1
(CARBONIC ANHYDRASE
13)		 3hm4 CHEMOTAXIS PROTEIN
CHEX
(Desulfovibrio
alaskensis) 		5 / 12 VAL A  61
VAL A 150
LEU A  20
VAL A  19
VAL A  71
 None
 0.98A 3czvA-3hm4A:
undetectable
3czvB-3hm4A:
undetectable		 3czvA-3hm4A:
23.08
3czvB-3hm4A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_C_TOPC200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3hm4 CHEMOTAXIS PROTEIN
CHEX
(Desulfovibrio
alaskensis) 		5 / 11 ALA A  15
LEU A 106
ILE A  51
LEU A 154
THR A  14
 None
 1.30A 3fl9C-3hm4A:
undetectable		 3fl9C-3hm4A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_H_TOPH200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3hm4 CHEMOTAXIS PROTEIN
CHEX
(Desulfovibrio
alaskensis) 		5 / 9 ALA A  15
LEU A 106
ILE A  51
LEU A 154
THR A  14
 None
 1.29A 3fl9H-3hm4A:
undetectable		 3fl9H-3hm4A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_1
(CYTOCHROME P450 3A5)		 3hm4 CHEMOTAXIS PROTEIN
CHEX
(Desulfovibrio
alaskensis) 		5 / 12 ILE A 121
ALA A  47
THR A  95
ALA A 116
GLY A  57
 None
None
None
UNL  A 156 (-3.1A)
None
 1.10A 5veuA-3hm4A:
undetectable		 5veuA-3hm4A:
16.18