SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hm8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3hm8 HEXOKINASE-3
(Homo
sapiens) 		3 / 3 MET A 504
ASN A 689
GLN A 745
 None
GLC  A1001 (-3.8A)
GLC  A1001 (-3.8A)
 0.93A 1xoqB-3hm8A:
undetectable		 1xoqB-3hm8A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A7Q_A_CFBA328_2
(DEOXYCYTIDINE KINASE)		 3hm8 HEXOKINASE-3
(Homo
sapiens) 		4 / 4 ILE A 751
ASP A 720
LEU A 519
ARG A 835
 None
 1.21A 2a7qA-3hm8A:
undetectable		 2a7qA-3hm8A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_A_STRA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 3hm8 HEXOKINASE-3
(Homo
sapiens) 		5 / 11 ALA A 842
ALA A 846
ALA A 845
VAL A 864
LEU A 682
 None
 1.14A 4j6cA-3hm8A:
undetectable		 4j6cA-3hm8A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_B_STRB503_1
(CYTOCHROME P450
MONOOXYGENASE)		 3hm8 HEXOKINASE-3
(Homo
sapiens) 		5 / 10 ALA A 842
ALA A 846
ALA A 845
VAL A 864
LEU A 682
 None
 1.13A 4j6cB-3hm8A:
undetectable		 4j6cB-3hm8A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_A_TESA503_1
(CYTOCHROME P450
MONOOXYGENASE)		 3hm8 HEXOKINASE-3
(Homo
sapiens) 		5 / 12 ALA A 842
ALA A 846
ALA A 845
VAL A 864
LEU A 682
 None
 1.09A 4j6dA-3hm8A:
undetectable		 4j6dA-3hm8A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_B_TESB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 3hm8 HEXOKINASE-3
(Homo
sapiens) 		5 / 12 ALA A 842
ALA A 846
ALA A 845
VAL A 864
LEU A 682
 None
 1.11A 4j6dB-3hm8A:
undetectable		 4j6dB-3hm8A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_A_ASDA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 3hm8 HEXOKINASE-3
(Homo
sapiens) 		5 / 12 ALA A 842
ALA A 846
ALA A 845
VAL A 864
LEU A 682
 None
 1.11A 4jbtA-3hm8A:
1.1		 4jbtA-3hm8A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_B_ASDB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 3hm8 HEXOKINASE-3
(Homo
sapiens) 		5 / 11 ALA A 842
ALA A 846
ALA A 845
VAL A 864
LEU A 682
 None
 1.12A 4jbtB-3hm8A:
undetectable		 4jbtB-3hm8A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT8_A_TMQA302_1
(RV2671)		 3hm8 HEXOKINASE-3
(Homo
sapiens) 		5 / 12 ILE A 683
GLY A 868
ASP A 663
GLU A 748
THR A 664
 GLC  A1001 (-4.2A)
BG6  A1002 (-3.5A)
GLC  A1001 ( 2.9A)
GLC  A1001 (-3.1A)
GLC  A1001 (-4.1A)
 1.33A 4xt8A-3hm8A:
undetectable		 4xt8A-3hm8A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_2
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 3hm8 HEXOKINASE-3
(Homo
sapiens) 		3 / 3 VAL A 500
ARG A 730
PRO A 489
 None
 0.74A 5koxA-3hm8A:
undetectable		 5koxA-3hm8A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_2
(CYTOCHROME P450 3A5)		 3hm8 HEXOKINASE-3
(Homo
sapiens) 		4 / 5 ARG A 644
PHE A 608
LEU A 642
LEU A 604
 None
 1.26A 5veuH-3hm8A:
1.4		 5veuH-3hm8A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W3J_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3hm8 HEXOKINASE-3
(Homo
sapiens) 		4 / 8 VAL A 639
ASP A 638
GLN A 619
GLY A 616
 None
 0.90A 5w3jB-3hm8A:
undetectable		 5w3jB-3hm8A:
20.43