SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hmb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_A_TESA325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 3hmb N-ACETYLMURAMOYL-L-A
LANINE AMIDASE XLYA
(Bacillus
subtilis) 		4 / 7 LEU A  69
HIS A  57
TRP A  76
ASN A  86
 None
 1.20A 1afsA-3hmbA:
undetectable		 1afsA-3hmbA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_B_TESB325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 3hmb N-ACETYLMURAMOYL-L-A
LANINE AMIDASE XLYA
(Bacillus
subtilis) 		4 / 7 LEU A  69
HIS A  57
TRP A  76
ASN A  86
 None
 1.20A 1afsB-3hmbA:
undetectable		 1afsB-3hmbA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_2
(PROTEIN (HIV-1
PROTEASE))		 3hmb N-ACETYLMURAMOYL-L-A
LANINE AMIDASE XLYA
(Bacillus
subtilis) 		4 / 8 LEU A  47
ALA A  13
GLY A  18
ILE A   9
 None
 0.67A 1d4yB-3hmbA:
undetectable		 1d4yB-3hmbA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB927_0
(FERROCHELATASE)		 3hmb N-ACETYLMURAMOYL-L-A
LANINE AMIDASE XLYA
(Bacillus
subtilis) 		3 / 3 LEU A  69
PRO A  70
ARG A  87
 None
 0.60A 2qd4B-3hmbA:
undetectable		 2qd4B-3hmbA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3hmb N-ACETYLMURAMOYL-L-A
LANINE AMIDASE XLYA
(Bacillus
subtilis) 		4 / 8 ILE A 113
PRO A 139
HIS A 130
GLY A  91
 None
None
ZN  A 155 (-3.3A)
None
 0.95A 3em0B-3hmbA:
undetectable		 3em0B-3hmbA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_G_ACTG225_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3hmb N-ACETYLMURAMOYL-L-A
LANINE AMIDASE XLYA
(Bacillus
subtilis) 		3 / 3 PRO A  70
LEU A  71
GLN A  67
 None
 0.57A 3hznG-3hmbA:
undetectable
3hznH-3hmbA:
undetectable		 3hznG-3hmbA:
20.59
3hznH-3hmbA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3hmb N-ACETYLMURAMOYL-L-A
LANINE AMIDASE XLYA
(Bacillus
subtilis) 		5 / 12 ILE A  26
ALA A 118
LYS A 114
ILE A  65
ILE A  92
 None
 0.89A 4kjjA-3hmbA:
undetectable		 4kjjA-3hmbA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA303_1
(CHITOSANASE)		 3hmb N-ACETYLMURAMOYL-L-A
LANINE AMIDASE XLYA
(Bacillus
subtilis) 		4 / 6 GLU A  93
TYR A  46
THR A  54
HIS A 130
 None
None
None
ZN  A 155 (-3.3A)
 1.21A 4qwpA-3hmbA:
undetectable		 4qwpA-3hmbA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA406_0
(THIOREDOXIN
REDUCTASE)		 3hmb N-ACETYLMURAMOYL-L-A
LANINE AMIDASE XLYA
(Bacillus
subtilis) 		3 / 3 HIS A  57
SER A  55
ARG A  16
 None
 0.89A 5u63A-3hmbA:
undetectable		 5u63A-3hmbA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3hmb N-ACETYLMURAMOYL-L-A
LANINE AMIDASE XLYA
(Bacillus
subtilis) 		4 / 6 ILE A  92
ILE A   9
LEU A  47
HIS A  43
 None
 1.04A 5vkqC-3hmbA:
undetectable
5vkqD-3hmbA:
undetectable		 5vkqC-3hmbA:
6.78
5vkqD-3hmbA:
6.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3hmb N-ACETYLMURAMOYL-L-A
LANINE AMIDASE XLYA
(Bacillus
subtilis) 		4 / 7 HIS A  43
ASP A  39
ASP A  99
GLY A 100
 None
 0.99A 5x7pA-3hmbA:
undetectable		 5x7pA-3hmbA:
7.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUP_B_DZPB502_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT BETA-3)		 3hmb N-ACETYLMURAMOYL-L-A
LANINE AMIDASE XLYA
(Bacillus
subtilis) 		5 / 11 ILE A 153
LEU A 124
THR A  27
LEU A 116
MET A 117
 None
 1.46A 6hupA-3hmbA:
undetectable
6hupB-3hmbA:
undetectable		 6hupA-3hmbA:
18.95
6hupB-3hmbA:
17.32