SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hmc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_A_NCAA700_0
(EXOTOXIN A)		 3hmc PUTATIVE PROPHAGE
LAMBDABA04, GLYCOSYL
HYDROLASE, FAMILY 25
(Bacillus
anthracis) 		4 / 7 TYR A 124
ALA A  62
TYR A  61
GLU A  95
 MES  A 400 (-3.6A)
None
MES  A 400 (-4.0A)
MES  A 400 (-3.5A)
 0.76A 1dmaA-3hmcA:
undetectable		 1dmaA-3hmcA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_C_AG2C7004_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 3hmc PUTATIVE PROPHAGE
LAMBDABA04, GLYCOSYL
HYDROLASE, FAMILY 25
(Bacillus
anthracis) 		4 / 6 ALA A  72
LEU A 113
GLU A  75
LEU A 123
 None
 0.96A 1mt1D-3hmcA:
undetectable
1mt1E-3hmcA:
undetectable		 1mt1D-3hmcA:
19.13
1mt1E-3hmcA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		 3hmc PUTATIVE PROPHAGE
LAMBDABA04, GLYCOSYL
HYDROLASE, FAMILY 25
(Bacillus
anthracis) 		4 / 7 TYR A  61
VAL A  91
ILE A 159
ASP A   9
 MES  A 400 (-4.0A)
None
None
MES  A 400 ( 4.0A)
 1.22A 2x45B-3hmcA:
undetectable		 2x45B-3hmcA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)		 3hmc PUTATIVE PROPHAGE
LAMBDABA04, GLYCOSYL
HYDROLASE, FAMILY 25
(Bacillus
anthracis) 		4 / 7 TYR A  61
VAL A  91
ILE A 159
ASP A   9
 MES  A 400 (-4.0A)
None
None
MES  A 400 ( 4.0A)
 1.24A 2x45C-3hmcA:
undetectable		 2x45C-3hmcA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 3hmc PUTATIVE PROPHAGE
LAMBDABA04, GLYCOSYL
HYDROLASE, FAMILY 25
(Bacillus
anthracis) 		3 / 3 GLY A 117
TRP A  90
VAL A 121
 None
 0.77A 3n62B-3hmcA:
undetectable		 3n62B-3hmcA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N65_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 3hmc PUTATIVE PROPHAGE
LAMBDABA04, GLYCOSYL
HYDROLASE, FAMILY 25
(Bacillus
anthracis) 		3 / 3 GLY A 117
TRP A  90
VAL A 121
 None
 0.75A 3n65B-3hmcA:
undetectable		 3n65B-3hmcA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 3hmc PUTATIVE PROPHAGE
LAMBDABA04, GLYCOSYL
HYDROLASE, FAMILY 25
(Bacillus
anthracis) 		3 / 3 GLY A 117
TRP A  90
VAL A 121
 None
 0.77A 3n66B-3hmcA:
undetectable		 3n66B-3hmcA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_A_NCAA1536_0
(DIPHTHERIA TOXIN)		 3hmc PUTATIVE PROPHAGE
LAMBDABA04, GLYCOSYL
HYDROLASE, FAMILY 25
(Bacillus
anthracis) 		4 / 6 TYR A 124
ALA A  62
TYR A  61
GLU A  95
 MES  A 400 (-3.6A)
None
MES  A 400 (-4.0A)
MES  A 400 (-3.5A)
 0.87A 4ae1A-3hmcA:
undetectable		 4ae1A-3hmcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRH_D_RAPD201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 3hmc PUTATIVE PROPHAGE
LAMBDABA04, GLYCOSYL
HYDROLASE, FAMILY 25
(Bacillus
anthracis) 		5 / 12 ASP A  27
HIS A   3
ILE A 171
PRO A  57
ILE A  29
 None
 1.14A 4drhD-3hmcA:
undetectable		 4drhD-3hmcA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 3hmc PUTATIVE PROPHAGE
LAMBDABA04, GLYCOSYL
HYDROLASE, FAMILY 25
(Bacillus
anthracis) 		3 / 3 ALA A  87
GLN A  34
GLY A  36
 None
 0.61A 4odoC-3hmcA:
undetectable		 4odoC-3hmcA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_ACTB804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hmc PUTATIVE PROPHAGE
LAMBDABA04, GLYCOSYL
HYDROLASE, FAMILY 25
(Bacillus
anthracis) 		3 / 3 GLY A 117
TRP A  90
VAL A 121
 None
 0.76A 5vuoB-3hmcA:
undetectable		 5vuoB-3hmcA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CJK_C_ACTC301_0
(IMMUNOGLOBULIN FAB
LIGHT CHAIN)		 3hmc PUTATIVE PROPHAGE
LAMBDABA04, GLYCOSYL
HYDROLASE, FAMILY 25
(Bacillus
anthracis) 		4 / 4 VAL A  89
GLY A 122
ASP A 141
ASP A 158
 None
 1.21A 6cjkC-3hmcA:
undetectable		 6cjkC-3hmcA:
19.65