SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hmj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A27_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 12 SER A1308
VAL A1309
GLY A1589
ASN A1594
VAL A1655
 None
 1.43A 1a27A-3hmjA:
17.9		 1a27A-3hmjA:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_A_ADNA601_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 908
THR A 910
GLU A 912
LEU A 663
GLY A 662
 None
 1.35A 1d4fA-3hmjA:
7.1		 1d4fA-3hmjA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 7 PHE A 903
ALA A 924
PHE A 659
VAL A 922
VAL A 913
 None
 1.35A 1epbA-3hmjA:
undetectable		 1epbA-3hmjA:
6.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1002_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 12 PHE A1024
VAL A1021
VAL A1538
ILE A1605
SER A1602
 None
 1.17A 1fm4A-3hmjA:
undetectable		 1fm4A-3hmjA:
7.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3003_1
(SERUM ALBUMIN)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 6 PHE A1335
ILE A1189
ALA A1186
MET A1377
 None
 0.98A 1hk2A-3hmjA:
2.3		 1hk2A-3hmjA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2501_0
(FERROCHELATASE)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 12 MET A1445
LEU A1009
LEU A1013
ILE A1004
VAL A1656
 None
 1.43A 1hrkB-3hmjA:
3.1		 1hrkB-3hmjA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWI_A_CAMA418_0
(CYTOCHROME P450-CAM)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 8 THR A1490
LEU A1486
VAL A1771
VAL A1881
 None
 0.92A 1iwiA-3hmjA:
undetectable		 1iwiA-3hmjA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 12 ILE A1599
VAL A1538
SER A 415
GLY A1635
HIS A 422
 None
 0.90A 1kiaA-3hmjA:
6.0		 1kiaA-3hmjA:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M9J_A_CLWA906_1
(ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 5 VAL A1677
TYR A1237
MET A1234
GLU A1233
 None
 1.42A 1m9jA-3hmjA:
undetectable		 1m9jA-3hmjA:
12.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M9J_B_CLWB907_1
(ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 5 VAL A1677
TYR A1237
MET A1234
GLU A1233
 None
 1.42A 1m9jB-3hmjA:
0.2		 1m9jB-3hmjA:
12.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_A_AG2A7005_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 425
LEU A 472
ILE A 439
GLU A 431
 None
 0.97A 1mt1A-3hmjA:
undetectable
1mt1F-3hmjA:
undetectable		 1mt1A-3hmjA:
2.40
1mt1F-3hmjA:
4.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_L_AG2L7014_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 425
LEU A 472
ILE A 439
GLU A 431
 None
 0.95A 1n13I-3hmjA:
undetectable
1n13L-3hmjA:
0.0		 1n13I-3hmjA:
2.40
1n13L-3hmjA:
4.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 12 ILE A1599
VAL A1538
SER A 415
GLY A1635
HIS A 422
 None
 0.94A 1nbhB-3hmjA:
undetectable		 1nbhB-3hmjA:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 5 GLU A 419
LEU A 413
LEU A 416
LEU A 414
 None
 1.06A 1np1A-3hmjA:
undetectable		 1np1A-3hmjA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_C_DIFC2701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 12 SER A 289
LEU A 149
VAL A 264
ALA A 268
SER A 270
 None
 1.04A 1pxxC-3hmjA:
undetectable		 1pxxC-3hmjA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		3 / 3 VAL A 735
ALA A 399
HIS A1358
 None
 0.60A 1q23C-3hmjA:
undetectable		 1q23C-3hmjA:
7.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		3 / 3 VAL A 735
ALA A 399
HIS A1358
 None
 0.64A 1q23H-3hmjA:
1.3		 1q23H-3hmjA:
7.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		3 / 3 VAL A 735
ALA A 399
HIS A1358
 None
 0.53A 1q23G-3hmjA:
undetectable		 1q23G-3hmjA:
7.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		3 / 3 VAL A 735
ALA A 399
HIS A1358
 None
 0.63A 1q23L-3hmjA:
undetectable		 1q23L-3hmjA:
7.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 761
GLU A 756
THR A1371
ILE A 733
 None
 0.90A 1qvtA-3hmjA:
undetectable		 1qvtA-3hmjA:
6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 11 SER A1678
ILE A1386
ALA A1393
ILE A1400
PHE A 992
 None
 1.28A 1uduA-3hmjA:
undetectable		 1uduA-3hmjA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF2_0
(7-AMINO-ACTINOMYCIN
D)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		3 / 3 THR A 196
PRO A 198
THR A 197
 None
 0.86A 1unjF-3hmjA:
undetectable		 1unjF-3hmjA:
0.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2888_0
(AMINOMETHYLTRANSFERA
SE)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 10 LEU A 908
LEU A 909
ILE A 823
ILE A 721
LEU A 696
 None
 1.25A 1wopA-3hmjA:
undetectable		 1wopA-3hmjA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 12 TYR A1332
ILE A1211
VAL A1215
LEU A1291
ILE A1200
 None
 1.13A 1xozA-3hmjA:
undetectable		 1xozA-3hmjA:
11.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_A_GBNA502_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 8 GLY A1651
THR A1409
ALA A1408
VAL A1404
 None
 0.87A 2a1hA-3hmjA:
undetectable
2a1hB-3hmjA:
undetectable		 2a1hA-3hmjA:
13.09
2a1hB-3hmjA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_B_GBNB501_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 8 VAL A1404
GLY A1651
THR A1409
ALA A1408
 None
 0.88A 2a1hA-3hmjA:
undetectable
2a1hB-3hmjA:
undetectable		 2a1hA-3hmjA:
13.09
2a1hB-3hmjA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2002_1
(SERUM ALBUMIN)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 10 ALA A 924
LEU A 926
LEU A 908
LEU A 916
VAL A 913
 None
 1.20A 2bxeA-3hmjA:
undetectable		 2bxeA-3hmjA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 6 ALA A1390
TYR A1529
ILE A1019
ILE A1403
 None
 0.94A 2dcfA-3hmjA:
undetectable		 2dcfA-3hmjA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_C_CHDC310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 916
GLN A 918
LEU A 640
PHE A 659
 None
 1.01A 2dysC-3hmjA:
3.2
2dysJ-3hmjA:
undetectable		 2dysC-3hmjA:
8.54
2dysJ-3hmjA:
3.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		3 / 3 ALA A1587
GLY A1028
SER A1218
 None
 0.50A 2ivuA-3hmjA:
undetectable		 2ivuA-3hmjA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB501_1
(CYTOCHROME P450 2C8)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 9 ARG A1566
GLY A1569
ILE A1533
VAL A1572
ILE A1557
 None
 1.31A 2nnhB-3hmjA:
undetectable		 2nnhB-3hmjA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1002_0
(ALDEHYDE
DEHYDROGENASE A)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		3 / 3 GLY A 726
ARG A 442
TYR A 722
 None
 0.87A 2opxA-3hmjA:
4.3		 2opxA-3hmjA:
14.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 799
PRO A 921
GLY A 866
MET A 923
 None
 1.15A 2pnjB-3hmjA:
2.0		 2pnjB-3hmjA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1104_0
(FERROCHELATASE)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 824
PRO A 825
LEU A 846
 None
 0.37A 2qd5B-3hmjA:
undetectable		 2qd5B-3hmjA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA142_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 5 GLU A1156
PRO A1158
ILE A1157
GLY A1161
 None
 1.20A 2qeuA-3hmjA:
2.3
2qeuC-3hmjA:
3.5		 2qeuA-3hmjA:
6.06
2qeuC-3hmjA:
6.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCD_A_RAPA138_1
(OUTER MEMBRANE
PROTEIN MIP)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 11 ASP A 764
VAL A 822
ILE A 768
PRO A 770
VAL A 703
 None
 1.30A 2vcdA-3hmjA:
undetectable		 2vcdA-3hmjA:
6.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_B_REAB1445_1
(PUTATIVE CYTOCHROME
P450 120)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 12 ALA A1033
ALA A1222
VAL A1021
GLY A1402
PRO A1399
 None
 0.97A 2ve3B-3hmjA:
undetectable		 2ve3B-3hmjA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_FFOB505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 930
GLY A 870
LEU A 936
ASN A 881
GLY A 887
 None
 0.99A 2vmyA-3hmjA:
2.3		 2vmyA-3hmjA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WQ5_A_MIYA1120_1
(PHOSPHOLIPASE A2,
ACIDIC)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 930
TRP A 871
ALA A 885
GLY A 887
 None
 0.96A 2wq5A-3hmjA:
undetectable		 2wq5A-3hmjA:
4.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFF_A_QPSA600_1
(BETA-AMYLASE)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 12 ALA A1382
PHE A1343
SER A1249
GLY A1250
THR A1307
 None
CER  A2748 (-4.5A)
None
CER  A2748 ( 4.6A)
None
 1.19A 2xffA-3hmjA:
undetectable		 2xffA-3hmjA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 12 ILE A1326
PHE A1223
ALA A1033
ILE A1386
MET A1388
 None
 1.15A 2xkwB-3hmjA:
undetectable		 2xkwB-3hmjA:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 12 ILE A1326
PHE A1223
ALA A1033
LEU A1597
ILE A1386
 None
 1.06A 2xkwB-3hmjA:
undetectable		 2xkwB-3hmjA:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_B_SALB1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 10 ILE A1573
GLY A1537
THR A1633
PRO A1627
ILE A1599
 None
 1.18A 2y7wB-3hmjA:
undetectable		 2y7wB-3hmjA:
7.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM7_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 7 ALA A1390
TYR A1529
ILE A1019
ILE A1403
 None
 0.96A 2zm7A-3hmjA:
undetectable		 2zm7A-3hmjA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM8_A_ACAA511_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 8 ALA A1390
TYR A1529
ILE A1019
ILE A1403
 None
 0.97A 2zm8A-3hmjA:
undetectable		 2zm8A-3hmjA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 8 ALA A1390
TYR A1529
ILE A1019
ILE A1403
 None
 0.96A 2zmaA-3hmjA:
undetectable		 2zmaA-3hmjA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A27_A_SAMA250_1
(UNCHARACTERIZED
PROTEIN MJ1557)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		3 / 3 MET A 529
GLU A 889
ASN A 882
 None
 0.95A 3a27A-3hmjA:
5.6		 3a27A-3hmjA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BCR_A_AZZA940_1
(GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 5 ASN A1194
ALA A1195
GLY A1199
TYR A1198
 None
 1.17A 3bcrA-3hmjA:
undetectable		 3bcrA-3hmjA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 9 PRO A1571
VAL A1572
GLY A1537
ILE A1599
GLY A1574
 None
 1.49A 3csjB-3hmjA:
undetectable		 3csjB-3hmjA:
7.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAT_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 12 LEU A1009
VAL A1018
ILE A1665
ARG A1669
LEU A1394
 None
 1.12A 3datA-3hmjA:
undetectable		 3datA-3hmjA:
6.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_DXCC576_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 8 ALA A1855
ALA A1859
ILE A1837
GLU A1817
 None
 0.85A 3dtuC-3hmjA:
undetectable
3dtuD-3hmjA:
undetectable		 3dtuC-3hmjA:
14.74
3dtuD-3hmjA:
8.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 12 VAL A1219
SER A1293
TYR A1706
ILE A1228
TYR A1715
 None
 1.38A 3g8iA-3hmjA:
undetectable		 3g8iA-3hmjA:
8.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_A_EAAA212_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 7 PHE A1576
ILE A1599
THR A1633
GLY A1607
 None
 0.76A 3gssA-3hmjA:
undetectable		 3gssA-3hmjA:
7.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 4 LEU A 824
PRO A 825
LEU A 846
ARG A 852
 None
 1.28A 3hcoB-3hmjA:
2.0		 3hcoB-3hmjA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 824
PRO A 825
LEU A 846
 None
 0.45A 3hcrA-3hmjA:
2.0		 3hcrA-3hmjA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I9J_B_NCAB302_0
(ADP-RIBOSYL CYCLASE)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 6 LEU A1618
ASN A 407
SER A1554
PHE A1541
 None
 1.46A 3i9jB-3hmjA:
undetectable		 3i9jB-3hmjA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 12 GLU A1052
GLY A1049
GLY A1031
SER A1032
ILE A1056
 None
 1.14A 3k13A-3hmjA:
undetectable		 3k13A-3hmjA:
10.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 12 GLU A1052
GLY A1049
GLY A1031
SER A1032
ILE A1056
 None
 1.16A 3k13B-3hmjA:
undetectable		 3k13B-3hmjA:
10.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 12 GLU A1052
GLY A1049
GLY A1031
SER A1032
ILE A1056
 None
 1.15A 3k13C-3hmjA:
undetectable		 3k13C-3hmjA:
10.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_C_AG2C1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 8 LYS A1821
LEU A1834
TRP A1813
ASP A1772
 None
 0.83A 3n2oC-3hmjA:
4.5
3n2oD-3hmjA:
3.6		 3n2oC-3hmjA:
16.15
3n2oD-3hmjA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_A_AICA375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 11 GLY A 907
ARG A 641
LEU A 926
LEU A 660
LEU A 663
 None
 1.38A 3ndvA-3hmjA:
undetectable
3ndvB-3hmjA:
undetectable		 3ndvA-3hmjA:
12.28
3ndvB-3hmjA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_B_AICB376_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 660
LEU A 663
GLY A 907
ARG A 641
LEU A 926
 None
 1.38A 3ndvA-3hmjA:
undetectable
3ndvB-3hmjA:
undetectable		 3ndvA-3hmjA:
12.28
3ndvB-3hmjA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_C_AICC375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 11 GLY A 907
ARG A 641
LEU A 926
LEU A 660
LEU A 663
 None
 1.40A 3ndvC-3hmjA:
undetectable
3ndvD-3hmjA:
undetectable		 3ndvC-3hmjA:
12.28
3ndvD-3hmjA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_D_AICD374_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 660
LEU A 663
GLY A 907
ARG A 641
LEU A 926
 None
 1.38A 3ndvC-3hmjA:
undetectable
3ndvD-3hmjA:
undetectable		 3ndvC-3hmjA:
12.28
3ndvD-3hmjA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_2
(CYTOCHROME P450 3A4)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 9 ARG A1017
LEU A1452
THR A1528
GLU A1016
GLY A1011
 None
 1.05A 3nxuB-3hmjA:
undetectable		 3nxuB-3hmjA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OI8_A_ADNA2_1
(UNCHARACTERIZED
PROTEIN)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 6 ILE A1573
ASN A1570
HIS A 454
LEU A1625
 None
 1.13A 3oi8A-3hmjA:
undetectable		 3oi8A-3hmjA:
6.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_2
(CYCLIN-DEPENDENT
KINASE 8)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 7 LEU A 159
VAL A 155
VAL A 182
LEU A 150
ASP A 189
 None
 1.41A 3rgfA-3hmjA:
undetectable		 3rgfA-3hmjA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC1_1
(CYTOCHROME P450 2D6)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 638
PHE A 659
LEU A 908
GLY A 870
PHE A 771
 None
 1.31A 3tbgC-3hmjA:
2.5		 3tbgC-3hmjA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_D_C2FD1200_0
(GLYCINE
N-METHYLTRANSFERASE)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 12 SER A1730
TYR A1232
HIS A1703
TYR A1235
THR A1732
 None
 1.34A 3thrA-3hmjA:
4.8
3thrB-3hmjA:
5.7
3thrC-3hmjA:
5.6
3thrD-3hmjA:
5.8		 3thrA-3hmjA:
9.65
3thrB-3hmjA:
9.65
3thrC-3hmjA:
9.65
3thrD-3hmjA:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_2
(ADENOSINE KINASE)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 5 SER A 827
ILE A 688
TYR A 839
GLY A 870
 None
 1.02A 3uboB-3hmjA:
4.5		 3uboB-3hmjA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 916
GLY A 866
ILE A 823
ASP A 925
ALA A 924
 None
 1.22A 3uj7A-3hmjA:
undetectable		 3uj7A-3hmjA:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_0
(MNMC2)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 677
GLY A 729
LEU A 697
GLY A 726
ASN A 441
 None
 1.11A 3vywC-3hmjA:
4.7		 3vywC-3hmjA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_2
(PROTEASE)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 7 ARG A1680
ALA A1222
VAL A1287
ILE A1386
 None
 0.85A 3wsjB-3hmjA:
undetectable		 3wsjB-3hmjA:
5.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_2
(PROTEASE)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 7 LEU A1834
ALA A1855
VAL A1864
ILE A1837
 None
 0.78A 3wsjB-3hmjA:
undetectable		 3wsjB-3hmjA:
5.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7H_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		3 / 3 ARG A1609
THR A1581
TRP A1030
 None
 0.78A 4d7hA-3hmjA:
undetectable		 4d7hA-3hmjA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 12 THR A1300
PRO A1301
ASN A1245
ILE A1292
VAL A1219
 None
 1.09A 4eb6B-3hmjA:
4.1
4eb6C-3hmjA:
4.4		 4eb6B-3hmjA:
13.02
4eb6C-3hmjA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F5Z_A_BEZA302_0
(HALOALKANE
DEHALOGENASE)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 8 ASN A1510
ASP A1511
LEU A1320
TYR A1513
 None
 1.12A 4f5zA-3hmjA:
3.4		 4f5zA-3hmjA:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_A_PQNA846_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 10 SER A1284
ALA A1382
GLY A1330
ALA A1348
MET A1346
 None
 1.50A 4fe1A-3hmjA:
4.7
4fe1J-3hmjA:
undetectable		 4fe1A-3hmjA:
16.54
4fe1J-3hmjA:
2.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 12 ARG A1036
GLU A1026
GLY A1031
VAL A1021
ASN A1594
 None
 1.33A 4ffwA-3hmjA:
3.7		 4ffwA-3hmjA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_1
(METHYLTRANSFERASE
NSUN4)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		3 / 3 ASP A1612
ARG A1367
ASP A 403
 None
 0.86A 4fp9F-3hmjA:
5.3		 4fp9F-3hmjA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7A_A_MXDA1002_1
(ANDROGEN RECEPTOR)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		3 / 3 GLU A1040
TRP A1037
LYS A1578
 None
 0.56A 4k7aA-3hmjA:
undetectable		 4k7aA-3hmjA:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 12 LEU A1531
ALA A1596
ILE A1004
LEU A1661
GLY A1663
 None
 1.22A 4l9qB-3hmjA:
2.8		 4l9qB-3hmjA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A602_1
(SERUM ALBUMIN)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 432
ALA A 436
LYS A 491
TYR A 725
 None
 1.11A 4lb2A-3hmjA:
undetectable		 4lb2A-3hmjA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LS7_A_1X9A504_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		9 / 12 GLY A1250
ALA A1304
CYH A1305
PHE A1343
HIS A1542
THR A1544
HIS A1583
GLY A1645
PHE A1646
 CER  A2748 ( 4.6A)
CER  A2748 (-3.5A)
CER  A2748 (-1.8A)
CER  A2748 (-4.5A)
CER  A2748 (-4.6A)
CER  A2748 ( 4.2A)
CER  A2748 (-4.4A)
CER  A2748 ( 3.7A)
CER  A2748 (-3.3A)
 0.36A 4ls7A-3hmjA:
40.4		 4ls7A-3hmjA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LS7_B_1X9B503_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		8 / 12 ALA A1304
CYH A1305
PHE A1343
HIS A1542
THR A1544
HIS A1583
GLY A1645
PHE A1646
 CER  A2748 (-3.5A)
CER  A2748 (-1.8A)
CER  A2748 (-4.5A)
CER  A2748 (-4.6A)
CER  A2748 ( 4.2A)
CER  A2748 (-4.4A)
CER  A2748 ( 3.7A)
CER  A2748 (-3.3A)
 0.32A 4ls7A-3hmjA:
40.4
4ls7B-3hmjA:
40.3		 4ls7A-3hmjA:
12.38
4ls7B-3hmjA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_2
(ANCESTRAL STEROID
RECEPTOR 2)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 8 ALA A 867
PHE A 903
VAL A 671
PHE A 673
 None
 0.95A 4ltwA-3hmjA:
undetectable		 4ltwA-3hmjA:
8.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 7 VAL A1287
ILE A1328
ILE A1384
ALA A1222
 None
 0.86A 4lv9A-3hmjA:
undetectable		 4lv9A-3hmjA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 362
ARG A 359
MET A 352
 None
 0.84A 4m11C-3hmjA:
undetectable		 4m11C-3hmjA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 11 VAL A1864
ALA A1862
GLY A1770
GLY A1824
ASP A1866
 None
 1.24A 4mm9A-3hmjA:
undetectable		 4mm9A-3hmjA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 11 LEU A1015
ASP A1014
LEU A1320
ILE A1403
TYR A1529
 None
 1.09A 4odrA-3hmjA:
undetectable
4odrB-3hmjA:
undetectable		 4odrA-3hmjA:
4.26
4odrB-3hmjA:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJ4_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 151
LEU A 154
VAL A 155
ILE A 186
 None
 0.88A 4oj4A-3hmjA:
undetectable		 4oj4A-3hmjA:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_A_IPHA101_0
(INSULIN)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 10 LEU A 908
HIS A 639
LEU A 640
ALA A 924
LEU A 926
 None
 1.19A 4p65A-3hmjA:
undetectable
4p65B-3hmjA:
undetectable
4p65F-3hmjA:
undetectable
4p65H-3hmjA:
undetectable		 4p65A-3hmjA:
1.88
4p65B-3hmjA:
2.84
4p65F-3hmjA:
2.84
4p65H-3hmjA:
2.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 5 GLN A 861
LEU A 862
ASP A 766
ASP A 675
 None
 1.32A 4qtuD-3hmjA:
5.6		 4qtuD-3hmjA:
7.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 902
ALA A 667
ILE A 437
ASN A 441
ASN A 438
 None
 1.18A 4r3aA-3hmjA:
2.1		 4r3aA-3hmjA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UG5_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		3 / 3 ARG A1609
THR A1581
TRP A1030
 None
 0.76A 4ug5A-3hmjA:
0.3		 4ug5A-3hmjA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UGL_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		3 / 3 ARG A1609
THR A1581
TRP A1030
 None
 0.78A 4uglA-3hmjA:
undetectable		 4uglA-3hmjA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 7 VAL A1316
ILE A1403
ALA A1390
ARG A1523
 None
 0.85A 4uxqA-3hmjA:
undetectable		 4uxqA-3hmjA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_C_Y70C151_1
(CEREBLON ISOFORM 4)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 8 ASN A 829
PRO A 828
PHE A 833
TRP A 871
 None
 1.09A 4v2zC-3hmjA:
undetectable		 4v2zC-3hmjA:
5.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WCX_C_SAMC503_0
(BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 12 TYR A1332
GLY A1383
PHE A1223
LEU A1291
LEU A1290
 None
 1.26A 4wcxC-3hmjA:
2.5		 4wcxC-3hmjA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_B_QDNB602_1
(CYTOCHROME P450 2D6)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 9 LEU A1775
GLU A1464
ALA A1810
SER A1814
ALA A1880
 None
 1.43A 4wnuB-3hmjA:
undetectable		 4wnuB-3hmjA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XNX_A_41XA707_1
(TRANSPORTER)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 11 PHE A  35
ASP A  33
ASP A  69
TYR A  65
VAL A  44
 None
 1.25A 4xnxA-3hmjA:
undetectable		 4xnxA-3hmjA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 679
ILE A 752
ILE A 733
VAL A 735
PHE A 394
 None
 0.96A 4y0sA-3hmjA:
undetectable		 4y0sA-3hmjA:
6.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMK_A_EF2A151_1
(CEREBLON ISOFORM 4)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 8 ASN A 829
PRO A 828
PHE A 833
TRP A 871
 None
 1.10A 5amkA-3hmjA:
undetectable		 5amkA-3hmjA:
5.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_A_PZAA1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 7 VAL A1869
SER A1870
ALA A1880
GLY A1811
 None
 0.95A 5fpdA-3hmjA:
1.9		 5fpdA-3hmjA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6C_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		3 / 3 ARG A1609
THR A1581
TRP A1030
 None
 0.77A 5g6cA-3hmjA:
undetectable		 5g6cA-3hmjA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 668
SER A 523
VAL A 526
ASP A 661
 None
 1.28A 5hesA-3hmjA:
undetectable		 5hesA-3hmjA:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_I_IPHI101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 6 VAL A 153
HIS A 157
LEU A 154
LEU A 229
 None
 0.98A 5hrqB-3hmjA:
undetectable
5hrqI-3hmjA:
undetectable
5hrqJ-3hmjA:
undetectable		 5hrqB-3hmjA:
1.80
5hrqI-3hmjA:
1.88
5hrqJ-3hmjA:
1.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKM_A_SAMA311_0
(NS5 METHYL
TRANSFERASE)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 12 GLY A1589
GLY A1248
GLY A1586
VAL A1287
ILE A1328
 None
 0.93A 5ikmA-3hmjA:
4.1		 5ikmA-3hmjA:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_A_08JA602_1
(CYTOCHROME P450 3A4)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 7 ALA A1753
THR A1490
ILE A1493
LEU A1467
 None
 1.00A 5te8A-3hmjA:
undetectable		 5te8A-3hmjA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_A_OQRA302_0
(SULFOTRANSFERASE)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 9 PRO A 496
LEU A 522
LEU A 605
ASP A 600
SER A 523
 None
 1.39A 5tixA-3hmjA:
0.2		 5tixA-3hmjA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_B_OQRB302_0
(SULFOTRANSFERASE)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 10 PRO A 496
LEU A 522
LEU A 605
ASP A 600
SER A 523
 None
 1.42A 5tixB-3hmjA:
undetectable		 5tixB-3hmjA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_H_ADNH503_2
(ADENOSYLHOMOCYSTEINA
SE)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 5 THR A 610
GLU A 474
HIS A 454
LEU A 413
 None
 1.34A 5utuH-3hmjA:
2.6		 5utuH-3hmjA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		3 / 3 LYS A 996
PRO A 997
LYS A 999
 None
 1.01A 5y9yA-3hmjA:
undetectable		 5y9yA-3hmjA:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_D_BEZD201_0
(NS3 PROTEASE)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 5 ALA A 683
SER A 687
GLY A 686
TYR A 717
 None
 1.28A 5yodD-3hmjA:
undetectable		 5yodD-3hmjA:
6.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 916
GLN A 918
LEU A 640
PHE A 659
 None
 0.90A 5z84C-3hmjA:
3.3
5z84J-3hmjA:
undetectable		 5z84C-3hmjA:
8.54
5z84J-3hmjA:
3.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_D95A816_0
(GEPHYRIN)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 11 ILE A1103
LEU A1580
ILE A1097
MET A1057
MET A1053
 None
 0.95A 6fgcA-3hmjA:
1.9		 6fgcA-3hmjA:
3.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLO_A_GBQA1501_1
(SUBSTANCE-P
RECEPTOR,GLGA
GLYCOGEN
SYNTHASE,SUBSTANCE-P
RECEPTOR)		 3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 9 ASN A1594
ILE A1387
GLU A1310
VAL A1316
ILE A1019
 None
 1.45A 6hloA-3hmjA:
3.5		 6hloA-3hmjA:
13.71