SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hn2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DIT_P_2PPP1_1
(ALPHA-THROMBIN
PEPTIDE INHIBITOR
CVS995)		 3hn2 2-DEHYDROPANTOATE
2-REDUCTASE
(Geobacter
metallireducens) 		4 / 6 LEU A 297
ILE A 272
GLU A 268
ASP A 260
 None
 0.96A 1ditH-3hn2A:
undetectable
1ditP-3hn2A:
undetectable		 1ditH-3hn2A:
24.84
1ditP-3hn2A:
5.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4001_1
(SERUM ALBUMIN)		 3hn2 2-DEHYDROPANTOATE
2-REDUCTASE
(Geobacter
metallireducens) 		4 / 5 ARG A 181
LYS A 178
ALA A 180
GLY A 147
 None
 1.23A 1e7cA-3hn2A:
2.4		 1e7cA-3hn2A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_B_SALB4005_1
(XANTHINE
DEHYDROGENASE)		 3hn2 2-DEHYDROPANTOATE
2-REDUCTASE
(Geobacter
metallireducens) 		4 / 7 GLU A 268
ARG A 181
THR A  99
VAL A  73
 None
 1.07A 1fo4B-3hn2A:
undetectable		 1fo4B-3hn2A:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3hn2 2-DEHYDROPANTOATE
2-REDUCTASE
(Geobacter
metallireducens) 		4 / 8 GLY A  66
ALA A   4
ILE A  65
THR A  95
 None
 0.74A 1gtnP-3hn2A:
undetectable
1gtnQ-3hn2A:
undetectable		 1gtnP-3hn2A:
12.99
1gtnQ-3hn2A:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_B_SNLB503_2
(MINERALOCORTICOID
RECEPTOR)		 3hn2 2-DEHYDROPANTOATE
2-REDUCTASE
(Geobacter
metallireducens) 		4 / 5 LEU A 198
LEU A 194
LEU A 297
LEU A 296
 None
 0.96A 2ab2B-3hn2A:
undetectable		 2ab2B-3hn2A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_C_CHDC310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3hn2 2-DEHYDROPANTOATE
2-REDUCTASE
(Geobacter
metallireducens) 		4 / 7 LEU A 197
GLN A 199
LEU A 293
PHE A 273
 None
 1.02A 2dysC-3hn2A:
undetectable
2dysJ-3hn2A:
undetectable		 2dysC-3hn2A:
22.00
2dysJ-3hn2A:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_A_SALA2006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3hn2 2-DEHYDROPANTOATE
2-REDUCTASE
(Geobacter
metallireducens) 		4 / 6 ARG A 181
THR A  99
VAL A  73
LEU A  75
 None
 1.06A 2e1qA-3hn2A:
undetectable		 2e1qA-3hn2A:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3hn2 2-DEHYDROPANTOATE
2-REDUCTASE
(Geobacter
metallireducens) 		4 / 7 LEU A 197
GLN A 199
LEU A 293
PHE A 273
 None
 1.08A 2eimC-3hn2A:
undetectable
2eimJ-3hn2A:
undetectable		 2eimC-3hn2A:
22.00
2eimJ-3hn2A:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3hn2 2-DEHYDROPANTOATE
2-REDUCTASE
(Geobacter
metallireducens) 		4 / 7 LEU A 197
GLN A 199
LEU A 293
PHE A 273
 None
 0.98A 2zxwC-3hn2A:
undetectable
2zxwJ-3hn2A:
undetectable		 2zxwC-3hn2A:
22.00
2zxwJ-3hn2A:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 3hn2 2-DEHYDROPANTOATE
2-REDUCTASE
(Geobacter
metallireducens) 		4 / 6 GLY A  66
THR A  95
GLU A  64
GLU A  85
 None
 1.02A 3fpjA-3hn2A:
4.7		 3fpjA-3hn2A:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 3hn2 2-DEHYDROPANTOATE
2-REDUCTASE
(Geobacter
metallireducens) 		5 / 12 ILE A 144
GLN A  96
LEU A  19
VAL A 169
THR A 173
 None
 1.17A 3ix9A-3hn2A:
undetectable		 3ix9A-3hn2A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 3hn2 2-DEHYDROPANTOATE
2-REDUCTASE
(Geobacter
metallireducens) 		3 / 4 SER A 128
GLY A  74
GLU A 107
 None
 0.66A 3raeA-3hn2A:
2.3
3raeC-3hn2A:
undetectable		 3raeA-3hn2A:
23.55
3raeC-3hn2A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 3hn2 2-DEHYDROPANTOATE
2-REDUCTASE
(Geobacter
metallireducens) 		4 / 4 PHE A  28
TYR A  14
ILE A  87
LEU A  86
 None
 1.03A 3sudA-3hn2A:
undetectable		 3sudA-3hn2A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 3hn2 2-DEHYDROPANTOATE
2-REDUCTASE
(Geobacter
metallireducens) 		4 / 5 PHE A  28
TYR A  14
ILE A  87
LEU A  86
 None
 1.11A 3sueC-3hn2A:
undetectable		 3sueC-3hn2A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_A_MXMA606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3hn2 2-DEHYDROPANTOATE
2-REDUCTASE
(Geobacter
metallireducens) 		5 / 12 MET A 163
LEU A 160
ILE A   3
LEU A  19
LEU A  98
 None
 1.08A 4m11A-3hn2A:
undetectable		 4m11A-3hn2A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_1
(ANDROGEN RECEPTOR)		 3hn2 2-DEHYDROPANTOATE
2-REDUCTASE
(Geobacter
metallireducens) 		5 / 12 LEU A 197
LEU A 194
GLY A 193
THR A 301
MET A 257
 None
 1.11A 4ok1A-3hn2A:
undetectable		 4ok1A-3hn2A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKT_A_198A1001_1
(ANDROGEN RECEPTOR)		 3hn2 2-DEHYDROPANTOATE
2-REDUCTASE
(Geobacter
metallireducens) 		5 / 12 LEU A 197
LEU A 194
GLY A 193
THR A 301
MET A 257
 None
 1.14A 4oktA-3hn2A:
undetectable		 4oktA-3hn2A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSS_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3hn2 2-DEHYDROPANTOATE
2-REDUCTASE
(Geobacter
metallireducens) 		5 / 12 ILE A   5
ALA A  17
ALA A  10
ILE A 144
LEU A 100
 None
 0.96A 4pssA-3hn2A:
undetectable		 4pssA-3hn2A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSY_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3hn2 2-DEHYDROPANTOATE
2-REDUCTASE
(Geobacter
metallireducens) 		5 / 12 ILE A   5
ALA A  17
ALA A  10
ILE A 144
LEU A 100
 None
 0.98A 4psyA-3hn2A:
undetectable		 4psyA-3hn2A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYK_A_OAQA302_0
(SULFOTRANSFERASE)		 3hn2 2-DEHYDROPANTOATE
2-REDUCTASE
(Geobacter
metallireducens) 		5 / 12 MET A  68
ILE A   3
VAL A  73
VAL A   6
LEU A  19
 None
 1.09A 5bykA-3hn2A:
undetectable		 5bykA-3hn2A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZJ_A_TEPA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 3hn2 2-DEHYDROPANTOATE
2-REDUCTASE
(Geobacter
metallireducens) 		4 / 8 LEU A 100
PHE A 164
LEU A  70
ILE A   3
 None
 1.02A 5mzjA-3hn2A:
2.5		 5mzjA-3hn2A:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_H_SAMH501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 3hn2 2-DEHYDROPANTOATE
2-REDUCTASE
(Geobacter
metallireducens) 		5 / 10 LEU A  75
GLY A   9
GLY A  12
LEU A  86
LEU A  29
 None
 1.00A 5o96G-3hn2A:
undetectable
5o96H-3hn2A:
undetectable		 5o96G-3hn2A:
24.93
5o96H-3hn2A:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B52_A_OAQA302_0
(SULFOTRANSFERASE)		 3hn2 2-DEHYDROPANTOATE
2-REDUCTASE
(Geobacter
metallireducens) 		5 / 12 MET A  68
ILE A   3
VAL A  73
VAL A   6
LEU A  19
 None
 1.12A 6b52A-3hn2A:
undetectable		 6b52A-3hn2A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_1
(CYTOCHROME P450 1A1)		 3hn2 2-DEHYDROPANTOATE
2-REDUCTASE
(Geobacter
metallireducens) 		5 / 7 SER A 128
GLY A   9
ALA A   8
VAL A  56
LEU A  42
 None
 1.35A 6dwnB-3hn2A:
undetectable		 6dwnB-3hn2A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_A_BEZA502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 3hn2 2-DEHYDROPANTOATE
2-REDUCTASE
(Geobacter
metallireducens) 		4 / 6 VAL A  26
LEU A  42
LEU A  53
HIS A  55
 None
 0.89A 6e43A-3hn2A:
undetectable		 6e43A-3hn2A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_B_BEZB502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 3hn2 2-DEHYDROPANTOATE
2-REDUCTASE
(Geobacter
metallireducens) 		4 / 6 VAL A  26
LEU A  42
LEU A  53
HIS A  55
 None
 0.95A 6e43B-3hn2A:
undetectable		 6e43B-3hn2A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_C_BEZC502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 3hn2 2-DEHYDROPANTOATE
2-REDUCTASE
(Geobacter
metallireducens) 		4 / 6 VAL A  26
LEU A  42
LEU A  53
HIS A  55
 None
 0.92A 6e43C-3hn2A:
undetectable		 6e43C-3hn2A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_D_BEZD502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 3hn2 2-DEHYDROPANTOATE
2-REDUCTASE
(Geobacter
metallireducens) 		4 / 6 VAL A  26
LEU A  42
LEU A  53
HIS A  55
 None
 0.93A 6e43D-3hn2A:
undetectable		 6e43D-3hn2A:
18.80