SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hno'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_B_MTXB171_1
(DIHYDROFOLATE
REDUCTASE)		 3hno PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE
(Nitrosospira
multiformis) 		5 / 12 VAL A 159
ALA A 302
GLU A 169
LEU A 187
ILE A 163
 None
 1.01A 1d1gB-3hnoA:
undetectable		 1d1gB-3hnoA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWI_A_CAMA418_0
(CYTOCHROME P450-CAM)		 3hno PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE
(Nitrosospira
multiformis) 		4 / 8 LEU A 286
VAL A 282
VAL A 214
VAL A 243
 None
 0.80A 1iwiA-3hnoA:
undetectable		 1iwiA-3hnoA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3hno PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE
(Nitrosospira
multiformis) 		3 / 3 VAL A 322
ALA A 321
HIS A 138
 None
 0.76A 1q23H-3hnoA:
undetectable		 1q23H-3hnoA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T86_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 3hno PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE
(Nitrosospira
multiformis) 		4 / 8 LEU A 286
VAL A 282
VAL A 214
VAL A 243
 None
 0.72A 1t86A-3hnoA:
undetectable		 1t86A-3hnoA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 3hno PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE
(Nitrosospira
multiformis) 		5 / 12 ILE A 215
LEU A 383
ILE A 387
MET A 363
PHE A 217
 None
 1.31A 1y0xX-3hnoA:
undetectable		 1y0xX-3hnoA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACHA546_0
(ACETYLCHOLINESTERASE)		 3hno PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE
(Nitrosospira
multiformis) 		4 / 8 TYR A  93
TYR A 110
PHE A 108
GLY A  45
 None
 1.03A 2ha4A-3hnoA:
undetectable		 2ha4A-3hnoA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 3hno PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE
(Nitrosospira
multiformis) 		3 / 3 ARG A  43
ASN A   5
THR A  57
 None
 0.71A 2q63A-3hnoA:
undetectable		 2q63A-3hnoA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3hno PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE
(Nitrosospira
multiformis) 		4 / 7 TRP A 196
THR A 150
CYH A 152
PHE A 367
 None
 1.23A 2qx4A-3hnoA:
4.1
2qx4B-3hnoA:
4.4		 2qx4A-3hnoA:
18.90
2qx4B-3hnoA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_B_ACTB1463_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 3hno PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE
(Nitrosospira
multiformis) 		4 / 7 VAL A 159
ILE A 197
ALA A 200
GLY A 157
 None
 0.77A 2xrzB-3hnoA:
2.4		 2xrzB-3hnoA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z97_A_CAMA422_0
(CYTOCHROME P450-CAM)		 3hno PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE
(Nitrosospira
multiformis) 		4 / 6 LEU A 286
VAL A 282
VAL A 214
VAL A 243
 None
 0.69A 2z97A-3hnoA:
undetectable		 2z97A-3hnoA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 3hno PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE
(Nitrosospira
multiformis) 		5 / 12 PRO A 276
GLY A 273
GLY A 272
ILE A 163
ALA A 295
 None
 0.96A 3douA-3hnoA:
undetectable		 3douA-3hnoA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_2
(HIV-1 PROTEASE)		 3hno PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE
(Nitrosospira
multiformis) 		5 / 10 GLY A 349
VAL A 348
PRO A 140
VAL A 139
ILE A 137
 None
 1.07A 3oxvB-3hnoA:
undetectable		 3oxvB-3hnoA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_2
(HIV-1 PROTEASE)		 3hno PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE
(Nitrosospira
multiformis) 		5 / 11 GLY A 349
VAL A 348
PRO A 140
VAL A 139
ILE A 137
 None
 1.04A 3oxvD-3hnoA:
undetectable		 3oxvD-3hnoA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_B_DXCB92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3hno PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE
(Nitrosospira
multiformis) 		4 / 5 VAL A 311
VAL A  17
ARG A 303
LYS A 161
 None
 1.42A 3rv5A-3hnoA:
undetectable
3rv5B-3hnoA:
undetectable		 3rv5A-3hnoA:
13.01
3rv5B-3hnoA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_4
(PROTEASE)		 3hno PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE
(Nitrosospira
multiformis) 		4 / 4 ASP A 144
ASP A 146
GLY A 113
THR A 150
 None
 1.32A 3tl9B-3hnoA:
undetectable		 3tl9B-3hnoA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3hno PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE
(Nitrosospira
multiformis) 		3 / 3 LYS A 308
GLU A 312
TRP A 346
 None
 1.44A 3v4tH-3hnoA:
1.3		 3v4tH-3hnoA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4B_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 3hno PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE
(Nitrosospira
multiformis) 		4 / 8 LEU A 286
VAL A 282
VAL A 214
VAL A 243
 None
 0.67A 4l4bA-3hnoA:
undetectable		 4l4bA-3hnoA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3hno PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE
(Nitrosospira
multiformis) 		5 / 12 LEU A 405
ALA A  41
PHE A  76
LEU A  68
GLY A  58
 None
 0.91A 4nkvB-3hnoA:
undetectable		 4nkvB-3hnoA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1W_A_017A104_1
(ASPARTYL PROTEASE)		 3hno PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE
(Nitrosospira
multiformis) 		5 / 9 LEU A  96
GLY A  45
ALA A   9
GLY A 112
VAL A 123
 None
 1.00A 4q1wA-3hnoA:
undetectable		 4q1wA-3hnoA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		 3hno PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE
(Nitrosospira
multiformis) 		4 / 8 SER A 116
TYR A 110
GLY A 112
GLY A  13
 None
 0.83A 5albL-3hnoA:
undetectable		 5albL-3hnoA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_2
(PROTEASE E35D-APV)		 3hno PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE
(Nitrosospira
multiformis) 		5 / 9 LEU A  96
GLY A  45
ALA A   9
GLY A 112
VAL A 123
 None
 0.98A 5kr0B-3hnoA:
undetectable		 5kr0B-3hnoA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 3hno PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE
(Nitrosospira
multiformis) 		4 / 8 LEU A 286
VAL A 282
VAL A 214
VAL A 243
 None
 0.71A 6cp4A-3hnoA:
undetectable		 6cp4A-3hnoA:
21.80