SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ho6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		 3ho6 TOXIN A
(Clostridioides
difficile) 		5 / 12 ILE A  42
TYR A 171
LEU A 175
VAL A 153
GLU A 134
 None
 1.26A 2bxfB-3ho6A:
undetectable		 2bxfB-3ho6A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_2
(PHOSPHOLIPASE A2)		 3ho6 TOXIN A
(Clostridioides
difficile) 		4 / 5 ILE A 146
SER A 147
PRO A 148
PRO A 188
 None
 1.30A 3bjwC-3ho6A:
undetectable		 3bjwC-3ho6A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 3ho6 TOXIN A
(Clostridioides
difficile) 		4 / 6 GLY A 157
THR A 109
GLU A 203
GLU A 213
 None
 0.95A 3fpjA-3ho6A:
undetectable		 3fpjA-3ho6A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_H_PZIH800_0
(GLUTAMATE RECEPTOR 2)		 3ho6 TOXIN A
(Clostridioides
difficile) 		4 / 8 SER A 185
SER A 136
LEU A 139
ASP A 140
 None
 0.94A 3lsfH-3ho6A:
undetectable		 3lsfH-3ho6A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N0H_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 3ho6 TOXIN A
(Clostridioides
difficile) 		5 / 11 ILE A  42
PHE A 123
PHE A 110
ILE A 197
VAL A 108
 None
 1.08A 3n0hA-3ho6A:
undetectable		 3n0hA-3ho6A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB323_0
(INVASIN IPAD)		 3ho6 TOXIN A
(Clostridioides
difficile) 		4 / 7 LEU A  19
ILE A  41
ILE A 111
LEU A  57
 None
 0.67A 3r9vA-3ho6A:
undetectable
3r9vB-3ho6A:
undetectable		 3r9vA-3ho6A:
23.57
3r9vB-3ho6A:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 3ho6 TOXIN A
(Clostridioides
difficile) 		5 / 12 ILE A  42
PHE A 123
PHE A 110
ILE A 197
VAL A 108
 None
 1.11A 3s3vA-3ho6A:
undetectable		 3s3vA-3ho6A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ0_X_DXCX75_0
(CYTOCHROME C7)		 3ho6 TOXIN A
(Clostridioides
difficile) 		4 / 7 ILE A 197
PHE A 123
LYS A 115
GLY A 114
 None
 1.18A 3sj0X-3ho6A:
undetectable		 3sj0X-3ho6A:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3ho6 TOXIN A
(Clostridioides
difficile) 		4 / 6 ASN A  27
GLU A  52
TYR A  18
LEU A  19
 None
 1.30A 4twdB-3ho6A:
undetectable
4twdC-3ho6A:
undetectable		 4twdB-3ho6A:
21.15
4twdC-3ho6A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3ho6 TOXIN A
(Clostridioides
difficile) 		4 / 6 ASN A  27
GLU A  52
TYR A  18
LEU A  19
 None
 1.14A 4twdI-3ho6A:
undetectable
4twdJ-3ho6A:
undetectable		 4twdI-3ho6A:
21.15
4twdJ-3ho6A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CXV_A_0HKA501_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)		 3ho6 TOXIN A
(Clostridioides
difficile) 		3 / 3 THR A 170
THR A 120
PHE A 123
 None
 0.83A 5cxvA-3ho6A:
undetectable		 5cxvA-3ho6A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSN_A_MMZA503_1
(FLAVIN-CONTAINING
MONOOXYGENASE)		 3ho6 TOXIN A
(Clostridioides
difficile) 		3 / 3 ASN A 200
SER A 234
SER A 233
 None
 0.77A 5gsnA-3ho6A:
undetectable		 5gsnA-3ho6A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 3ho6 TOXIN A
(Clostridioides
difficile) 		3 / 3 LYS A  35
ASN A  61
SER A  65
 IHP  A 270 ( 3.3A)
None
None
 1.07A 5yw0A-3ho6A:
undetectable		 5yw0A-3ho6A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FDY_U_DB8U302_1
(-)		 3ho6 TOXIN A
(Clostridioides
difficile) 		5 / 9 LEU A 155
PHE A 138
SER A 137
LEU A 139
ILE A 179
 None
 0.88A 6fdyU-3ho6A:
undetectable		 6fdyU-3ho6A:
21.19