SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ho8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_A_ACAA90_1
(PLASMINOGEN)		 3ho8 PYRUVATE CARBOXYLASE
(Staphylococcus
aureus) 		4 / 8 ASP A 586
ARG A 581
TYR A 845
THR A1035
 None
 1.46A 1ceaA-3ho8A:
undetectable
1ceaB-3ho8A:
undetectable		 1ceaA-3ho8A:
6.25
1ceaB-3ho8A:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3ho8 PYRUVATE CARBOXYLASE
(Staphylococcus
aureus) 		3 / 3 SER A 833
GLU A 832
GLU A 829
 None
 0.71A 1eqbD-3ho8A:
undetectable		 1eqbD-3ho8A:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3ho8 PYRUVATE CARBOXYLASE
(Staphylococcus
aureus) 		3 / 3 SER A 833
GLU A 832
GLU A 829
 None
 0.71A 1eqbB-3ho8A:
undetectable		 1eqbB-3ho8A:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_A_VIBA502_1
(THIAMIN
PYROPHOSPHOKINASE)		 3ho8 PYRUVATE CARBOXYLASE
(Staphylococcus
aureus) 		4 / 8 LEU A 780
SER A 809
SER A 800
THR A 569
 None
 1.15A 1ig3A-3ho8A:
undetectable
1ig3B-3ho8A:
undetectable		 1ig3A-3ho8A:
12.75
1ig3B-3ho8A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ISM_B_NCAB305_0
(BONE MARROW STROMAL
CELL ANTIGEN 1)		 3ho8 PYRUVATE CARBOXYLASE
(Staphylococcus
aureus) 		4 / 7 HIS A 773
LEU A 577
SER A 576
ASP A 572
 MN  A2002 (-3.4A)
None
None
MN  A2002 (-2.7A)
 1.26A 1ismB-3ho8A:
undetectable		 1ismB-3ho8A:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JQD_A_HSMA600_1
(HISTAMINE
N-METHYLTRANSFERASE)		 3ho8 PYRUVATE CARBOXYLASE
(Staphylococcus
aureus) 		4 / 7 GLU A 381
GLN A 272
VAL A 274
ASN A 458
 None
 1.38A 1jqdA-3ho8A:
undetectable		 1jqdA-3ho8A:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3ho8 PYRUVATE CARBOXYLASE
(Staphylococcus
aureus) 		4 / 6 LEU A 982
VAL A 907
ILE A 952
ARG A 675
 None
 1.10A 1opjB-3ho8A:
undetectable		 1opjB-3ho8A:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_A_MTXA351_1
(PTERIDINE REDUCTASE
1)		 3ho8 PYRUVATE CARBOXYLASE
(Staphylococcus
aureus) 		5 / 12 PHE A 612
LEU A1012
TYR A1013
TYR A 616
MET A 641
 None
 1.50A 1p33A-3ho8A:
4.3		 1p33A-3ho8A:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_H_TRPH81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ho8 PYRUVATE CARBOXYLASE
(Staphylococcus
aureus) 		5 / 10 HIS A 769
THR A 541
ILE A 699
GLY A 601
THR A 566
 None
 1.17A 1utdH-3ho8A:
undetectable
1utdI-3ho8A:
undetectable		 1utdH-3ho8A:
5.13
1utdI-3ho8A:
5.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPO_H_TESH1010_1
(ANTI-TESTOSTERONE
(HEAVY CHAIN)
ANTI-TESTOSTERONE
(LIGHT CHAIN))		 3ho8 PYRUVATE CARBOXYLASE
(Staphylococcus
aureus) 		5 / 12 TYR A 304
ALA A 159
LEU A 164
PHE A 312
VAL A 249
 None
 1.34A 1vpoH-3ho8A:
undetectable
1vpoL-3ho8A:
2.9		 1vpoH-3ho8A:
11.53
1vpoL-3ho8A:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XR2_B_C2FB1201_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 3ho8 PYRUVATE CARBOXYLASE
(Staphylococcus
aureus) 		4 / 8 LYS A 741
THR A 611
SER A 806
GLU A 849
 MN  A2002 (-3.1A)
None
None
None
 1.31A 1xr2B-3ho8A:
9.2		 1xr2B-3ho8A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3ho8 PYRUVATE CARBOXYLASE
(Staphylococcus
aureus) 		5 / 9 LEU A1030
LEU A1032
LEU A1033
ILE A1050
ARG A 496
 None
 1.24A 2f78A-3ho8A:
undetectable		 2f78A-3ho8A:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3ho8 PYRUVATE CARBOXYLASE
(Staphylococcus
aureus) 		5 / 9 LEU A1030
LEU A1032
LEU A1033
ILE A1050
ARG A 496
 None
 1.23A 2f78B-3ho8A:
undetectable		 2f78B-3ho8A:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3ho8 PYRUVATE CARBOXYLASE
(Staphylococcus
aureus) 		5 / 9 LEU A1030
LEU A1032
LEU A1033
ILE A1050
ARG A 496
 None
 1.14A 2f7aA-3ho8A:
undetectable		 2f7aA-3ho8A:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3ho8 PYRUVATE CARBOXYLASE
(Staphylococcus
aureus) 		5 / 9 LEU A1030
LEU A1032
LEU A1033
ILE A1050
ARG A 496
 None
 1.14A 2f7aB-3ho8A:
undetectable		 2f7aB-3ho8A:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3ho8 PYRUVATE CARBOXYLASE
(Staphylococcus
aureus) 		5 / 11 ALA A 645
ILE A 676
VAL A 683
ILE A 704
PHE A 735
 None
 1.24A 2h42A-3ho8A:
undetectable		 2h42A-3ho8A:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_A_SCKA901_1
(ACETYLCHOLINESTERASE)		 3ho8 PYRUVATE CARBOXYLASE
(Staphylococcus
aureus) 		4 / 8 ASP A1006
TRP A 624
TYR A 616
TYR A1017
 None
 1.40A 2ha2A-3ho8A:
3.1		 2ha2A-3ho8A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_B_SCKB951_1
(ACETYLCHOLINESTERASE)		 3ho8 PYRUVATE CARBOXYLASE
(Staphylococcus
aureus) 		4 / 8 ASP A1006
TRP A 624
TYR A 616
TYR A1017
 None
 1.41A 2ha2B-3ho8A:
undetectable		 2ha2B-3ho8A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_1
(HIV-1 PROTEASE)		 3ho8 PYRUVATE CARBOXYLASE
(Staphylococcus
aureus) 		5 / 12 ALA A 113
ASP A 112
ILE A 349
ILE A  61
ILE A 139
 None
 0.83A 2hs1A-3ho8A:
undetectable		 2hs1A-3ho8A:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_B_T44B128_1
(TRANSTHYRETIN)		 3ho8 PYRUVATE CARBOXYLASE
(Staphylococcus
aureus) 		4 / 6 LEU A 577
ALA A 573
LEU A 578
THR A 569
 None
 1.11A 2roxB-3ho8A:
undetectable		 2roxB-3ho8A:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_F_CSCF1383_2
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 3ho8 PYRUVATE CARBOXYLASE
(Staphylococcus
aureus) 		3 / 3 LEU A 643
MET A 641
MET A 743
 None
 0.68A 2vavF-3ho8A:
undetectable		 2vavF-3ho8A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1358_1
(PROSTAGLANDIN
REDUCTASE 2)		 3ho8 PYRUVATE CARBOXYLASE
(Staphylococcus
aureus) 		4 / 6 ASP A 475
TYR A 372
PHE A 471
TYR A 476
 None
 1.20A 2w98A-3ho8A:
4.6
2w98B-3ho8A:
4.6		 2w98A-3ho8A:
14.90
2w98B-3ho8A:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3ho8 PYRUVATE CARBOXYLASE
(Staphylococcus
aureus) 		4 / 8 TYR A 723
LEU A 720
LEU A 755
ALA A 751
 None
 0.88A 2wekA-3ho8A:
5.1		 2wekA-3ho8A:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1467_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 3ho8 PYRUVATE CARBOXYLASE
(Staphylococcus
aureus) 		4 / 5 ARG A 675
ASP A 795
ILE A 794
GLU A 701
 None
 1.13A 2xrzA-3ho8A:
undetectable
2xrzB-3ho8A:
undetectable		 2xrzA-3ho8A:
18.54
2xrzB-3ho8A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3ho8 PYRUVATE CARBOXYLASE
(Staphylococcus
aureus) 		4 / 7 TYR A 654
VAL A 649
TYR A 651
TYR A1013
 None
 1.34A 2xz5B-3ho8A:
undetectable
2xz5E-3ho8A:
undetectable		 2xz5B-3ho8A:
11.96
2xz5E-3ho8A:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3ho8 PYRUVATE CARBOXYLASE
(Staphylococcus
aureus) 		4 / 7 TYR A 654
VAL A 649
TYR A 651
TYR A1013
 None
 1.34A 2xz5D-3ho8A:
undetectable
2xz5E-3ho8A:
undetectable		 2xz5D-3ho8A:
11.96
2xz5E-3ho8A:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		 3ho8 PYRUVATE CARBOXYLASE
(Staphylococcus
aureus) 		4 / 5 GLN A 248
ALA A 307
GLN A 348
ILE A 344
 None
 1.30A 2z0aA-3ho8A:
undetectable		 2z0aA-3ho8A:
5.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A65_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3ho8 PYRUVATE CARBOXYLASE
(Staphylococcus
aureus) 		5 / 12 MET A1042
TYR A1078
ASN A1044
GLY A1041
ILE A 504
 None
 1.42A 3a65A-3ho8A:
undetectable		 3a65A-3ho8A:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3ho8 PYRUVATE CARBOXYLASE
(Staphylococcus
aureus) 		4 / 5 ILE A1089
TYR A1078
ARG A1085
THR A 500
 None
None
COA  A2001 (-3.5A)
None
 1.47A 3abkN-3ho8A:
undetectable
3abkW-3ho8A:
undetectable		 3abkN-3ho8A:
17.96
3abkW-3ho8A:
4.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_A_SAMA206_0
(UPF0217 PROTEIN
MJ1640)		 3ho8 PYRUVATE CARBOXYLASE
(Staphylococcus
aureus) 		4 / 6 LEU A 817
GLY A 819
LEU A 813
SER A 812
 None
 0.90A 3aiaA-3ho8A:
2.7		 3aiaA-3ho8A:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_A_TP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 3ho8 PYRUVATE CARBOXYLASE
(Staphylococcus
aureus) 		5 / 12 PHE A 598
LEU A 604
HIS A 771
ALA A 573
SER A 806
 None
None
MN  A2002 (-3.5A)
None
None
 1.40A 3apvA-3ho8A:
undetectable		 3apvA-3ho8A:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BUF_A_AEGA394_0
(BETA-SECRETASE 1)		 3ho8 PYRUVATE CARBOXYLASE
(Staphylococcus
aureus) 		4 / 5 LEU A 357
ILE A 367
ILE A 360
GLY A 251
 None
 0.86A 3bufA-3ho8A:
undetectable		 3bufA-3ho8A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GVU_A_STIA1001_2
(TYROSINE-PROTEIN
KINASE ABL2)		 3ho8 PYRUVATE CARBOXYLASE
(Staphylococcus
aureus) 		4 / 5 LYS A  79
VAL A 427
ILE A  50
TYR A  67
 None
 1.19A 3gvuA-3ho8A:
undetectable		 3gvuA-3ho8A:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3ho8 PYRUVATE CARBOXYLASE
(Staphylococcus
aureus) 		3 / 3 TYR A 862
GLY A 745
ASP A 742
 None
 0.71A 3ou6C-3ho8A:
3.0		 3ou6C-3ho8A:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_A_SAMA6734_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 3ho8 PYRUVATE CARBOXYLASE
(Staphylococcus
aureus) 		5 / 12 VAL A 693
ALA A 696
GLY A 697
ALA A 669
LEU A 643
 None
 1.13A 3qxyA-3ho8A:
undetectable		 3qxyA-3ho8A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_A_SAMA484_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 3ho8 PYRUVATE CARBOXYLASE
(Staphylococcus
aureus) 		5 / 11 VAL A 693
ALA A 696
GLY A 697
ALA A 669
LEU A 643
 None
 1.11A 3rc0A-3ho8A:
undetectable		 3rc0A-3ho8A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_B_SAMB480_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 3ho8 PYRUVATE CARBOXYLASE
(Staphylococcus
aureus) 		5 / 12 VAL A 693
ALA A 696
GLY A 697
ALA A 669
LEU A 643
 None
 1.10A 3rc0B-3ho8A:
undetectable		 3rc0B-3ho8A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_D_ACTD4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 3ho8 PYRUVATE CARBOXYLASE
(Staphylococcus
aureus) 		4 / 5 LEU A 919
LEU A 883
GLY A 884
GLY A 882
 None
 0.75A 3si7C-3ho8A:
undetectable
3si7D-3ho8A:
undetectable		 3si7C-3ho8A:
13.09
3si7D-3ho8A:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_C_MIYC2001_1
(TETX2 PROTEIN)		 3ho8 PYRUVATE CARBOXYLASE
(Staphylococcus
aureus) 		4 / 8 GLN A 807
HIS A 773
GLY A 608
MET A 587
 MN  A2002 ( 4.0A)
MN  A2002 (-3.4A)
None
None
 1.01A 3v3nC-3ho8A:
3.4		 3v3nC-3ho8A:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD507_1
(HEMOLYTIC LECTIN
CEL-III)		 3ho8 PYRUVATE CARBOXYLASE
(Staphylococcus
aureus) 		4 / 5 GLU A  94
GLY A  91
TYR A  96
ASP A  71
 None
 1.24A 3w9tD-3ho8A:
undetectable		 3w9tD-3ho8A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQT_C_C5EC301_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3ho8 PYRUVATE CARBOXYLASE
(Staphylococcus
aureus) 		4 / 8 TYR A 654
VAL A 649
TYR A 651
TYR A1013
 None
 1.31A 4bqtC-3ho8A:
undetectable
4bqtD-3ho8A:
undetectable		 4bqtC-3ho8A:
11.13
4bqtD-3ho8A:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 3ho8 PYRUVATE CARBOXYLASE
(Staphylococcus
aureus) 		3 / 3 HIS A 244
GLU A 332
ASN A 326
 None
 1.01A 4bupB-3ho8A:
undetectable		 4bupB-3ho8A:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_C_ACTC506_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3ho8 PYRUVATE CARBOXYLASE
(Staphylococcus
aureus) 		4 / 5 ARG A  51
ILE A  52
HIS A 115
GLY A 117
 None
 1.28A 4e7cC-3ho8A:
undetectable		 4e7cC-3ho8A:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3ho8 PYRUVATE CARBOXYLASE
(Staphylococcus
aureus) 		4 / 8 GLN A 364
ILE A 367
PHE A 357
GLY A 251
 None
 0.96A 4fgjA-3ho8A:
undetectable
4fgjB-3ho8A:
undetectable		 4fgjA-3ho8A:
12.42
4fgjB-3ho8A:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_A_MRVA1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 3ho8 PYRUVATE CARBOXYLASE
(Staphylococcus
aureus) 		4 / 7 GLN A 785
THR A 782
LEU A 747
THR A 719
 None
 1.15A 4mbsA-3ho8A:
undetectable		 4mbsA-3ho8A:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		 3ho8 PYRUVATE CARBOXYLASE
(Staphylococcus
aureus) 		5 / 7 LYS A 273
ASN A 326
ARG A 328
VAL A 331
GLU A 332
 None
 0.92A 4mv7A-3ho8A:
54.2		 4mv7A-3ho8A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		 3ho8 PYRUVATE CARBOXYLASE
(Staphylococcus
aureus) 		5 / 7 LYS A 273
ASN A 326
GLN A 330
VAL A 331
GLU A 332
 None
 1.06A 4mv7A-3ho8A:
54.2		 4mv7A-3ho8A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		 3ho8 PYRUVATE CARBOXYLASE
(Staphylococcus
aureus) 		5 / 7 LYS A 273
GLN A 330
VAL A 331
GLU A 332
ARG A 377
 None
 1.19A 4mv7A-3ho8A:
54.2		 4mv7A-3ho8A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_1
(GLUCOCORTICOID
RECEPTOR)		 3ho8 PYRUVATE CARBOXYLASE
(Staphylococcus
aureus) 		5 / 12 GLY A 540
GLN A 543
GLN A 640
THR A 566
ILE A 793
 None
 1.26A 4p6xG-3ho8A:
undetectable		 4p6xG-3ho8A:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		 3ho8 PYRUVATE CARBOXYLASE
(Staphylococcus
aureus) 		5 / 12 GLY A 540
GLN A 543
GLN A 640
THR A 566
ILE A 793
 None
 1.29A 4p6xI-3ho8A:
undetectable		 4p6xI-3ho8A:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLF_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3ho8 PYRUVATE CARBOXYLASE
(Staphylococcus
aureus) 		5 / 11 ILE A 794
LEU A 780
LYS A 784
LEU A 817
THR A 772
 None
 1.14A 4qlfA-3ho8A:
2.1		 4qlfA-3ho8A:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_LZUA3008_1
(ALDEHYDE OXIDASE)		 3ho8 PYRUVATE CARBOXYLASE
(Staphylococcus
aureus) 		4 / 8 ASP A  89
SER A  95
ARG A 101
PRO A  92
 None
 1.01A 4uhxA-3ho8A:
2.3		 4uhxA-3ho8A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_RTZA3009_1
(ALDEHYDE OXIDASE)		 3ho8 PYRUVATE CARBOXYLASE
(Staphylococcus
aureus) 		4 / 8 ASP A  89
SER A  95
ARG A 101
PRO A  92
 None
 1.01A 4uhxA-3ho8A:
2.4		 4uhxA-3ho8A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 3ho8 PYRUVATE CARBOXYLASE
(Staphylococcus
aureus) 		5 / 10 ALA A 797
THR A 796
GLY A 803
ASP A 572
SER A 576
 None
None
None
MN  A2002 (-2.7A)
None
 1.40A 5l66K-3ho8A:
undetectable
5l66L-3ho8A:
undetectable		 5l66K-3ho8A:
11.63
5l66L-3ho8A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 3ho8 PYRUVATE CARBOXYLASE
(Staphylococcus
aureus) 		5 / 10 ALA A 797
THR A 796
GLY A 803
ASP A 572
SER A 576
 None
None
None
MN  A2002 (-2.7A)
None
 1.40A 5l66Y-3ho8A:
undetectable
5l66Z-3ho8A:
undetectable		 5l66Y-3ho8A:
11.63
5l66Z-3ho8A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		 3ho8 PYRUVATE CARBOXYLASE
(Staphylococcus
aureus) 		4 / 6 THR A 908
ARG A 644
ASP A 678
GLY A 953
 None
 1.22A 5mraA-3ho8A:
undetectable
5mraB-3ho8A:
undetectable		 5mraA-3ho8A:
10.01
5mraB-3ho8A:
10.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MSD_A_BEZA1202_0
(CARBOXYLIC ACID
REDUCTASE)		 3ho8 PYRUVATE CARBOXYLASE
(Staphylococcus
aureus) 		4 / 5 ILE A 659
PHE A 674
SER A 666
ALA A 692
 None
 1.22A 5msdA-3ho8A:
1.7		 5msdA-3ho8A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUN_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 3ho8 PYRUVATE CARBOXYLASE
(Staphylococcus
aureus) 		5 / 9 ALA A 797
VAL A 798
ILE A 590
LEU A 834
ALA A 573
 None
 1.00A 5nunA-3ho8A:
undetectable		 5nunA-3ho8A:
5.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1103_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 3ho8 PYRUVATE CARBOXYLASE
(Staphylococcus
aureus) 		4 / 8 TYR A 118
GLN A 375
GLY A  46
ARG A  45
 None
 1.04A 5nzyA-3ho8A:
undetectable		 5nzyA-3ho8A:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIY_A_OAQA302_0
(SULFOTRANSFERASE)		 3ho8 PYRUVATE CARBOXYLASE
(Staphylococcus
aureus) 		5 / 11 ILE A 374
VAL A 405
SER A 446
MET A 338
THR A 334
 None
 1.50A 5tiyA-3ho8A:
undetectable		 5tiyA-3ho8A:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 3ho8 PYRUVATE CARBOXYLASE
(Staphylococcus
aureus) 		4 / 6 ARG A1085
ARG A 398
ALA A 416
GLN A1083
 COA  A2001 (-3.5A)
COA  A2001 (-3.3A)
None
None
 1.09A 6b89B-3ho8A:
undetectable		 6b89B-3ho8A:
6.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 3ho8 PYRUVATE CARBOXYLASE
(Staphylococcus
aureus) 		4 / 6 GLY A 902
ASN A 957
ASP A 903
SER A 716
 None
 1.18A 6dwdA-3ho8A:
undetectable
6dwdC-3ho8A:
undetectable		 6dwdA-3ho8A:
19.44
6dwdC-3ho8A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3ho8 PYRUVATE CARBOXYLASE
(Staphylococcus
aureus) 		4 / 7 HIS A 244
HIS A 333
GLU A 246
GLU A 123
 None
 1.15A 6mn4F-3ho8A:
undetectable		 6mn4F-3ho8A:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_A_LLLA301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3ho8 PYRUVATE CARBOXYLASE
(Staphylococcus
aureus) 		4 / 6 ASP A 408
GLU A 337
ASP A 343
GLU A  58
 None
 1.40A 6mn5A-3ho8A:
undetectable		 6mn5A-3ho8A:
4.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NCS_A_ACTA303_0
(N-ACETYLNEURAMINIC
ACID (SIALIC ACID)
SYNTHETASE)		 3ho8 PYRUVATE CARBOXYLASE
(Staphylococcus
aureus) 		3 / 3 ILE A 367
THR A 368
PRO A 362
 None
 0.62A 6ncsA-3ho8A:
5.6		 6ncsA-3ho8A:
15.27