SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hoa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC8_0
(ACTINOMYCIN D)		 3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1
(Thermus
thermophilus) 		3 / 3 THR A 429
THR A 431
PRO A 428
 None
 0.84A 1dscC-3hoaA:
undetectable		 1dscC-3hoaA:
2.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F86_B_T44B528_1
(TRANSTHYRETIN
THR119MET VARIANT)		 3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1
(Thermus
thermophilus) 		4 / 4 LYS A 397
LEU A 376
ALA A 393
LEU A 390
 None
 1.40A 1f86B-3hoaA:
undetectable		 1f86B-3hoaA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA8_0
(GRAMICIDIN A)		 3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1
(Thermus
thermophilus) 		3 / 4 VAL A  87
TRP A  66
TRP A  90
 None
 1.38A 1gmkA-3hoaA:
undetectable
1gmkB-3hoaA:
undetectable		 1gmkA-3hoaA:
2.78
1gmkB-3hoaA:
2.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3003_1
(SERUM ALBUMIN)		 3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1
(Thermus
thermophilus) 		3 / 4 LYS A  69
ALA A   6
MET A   1
 None
 1.01A 1hk3A-3hoaA:
undetectable		 1hk3A-3hoaA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1
(Thermus
thermophilus) 		5 / 12 HIS A 276
GLU A 277
HIS A 280
GLU A 306
TYR A 430
 None
 0.86A 1j36A-3hoaA:
21.5		 1j36A-3hoaA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1
(Thermus
thermophilus) 		5 / 12 HIS A 276
GLU A 277
HIS A 280
GLU A 306
TYR A 430
 None
 0.85A 1j36B-3hoaA:
21.5		 1j36B-3hoaA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_A_X8ZA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1
(Thermus
thermophilus) 		5 / 11 HIS A 276
GLU A 277
HIS A 280
GLU A 306
TYR A 430
 None
 0.88A 1j37A-3hoaA:
21.5		 1j37A-3hoaA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_A_X8ZA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1
(Thermus
thermophilus) 		5 / 11 HIS A 276
GLU A 277
HIS A 280
HIS A 418
TYR A 430
 None
 0.73A 1j37A-3hoaA:
21.5		 1j37A-3hoaA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_B_X8ZB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1
(Thermus
thermophilus) 		5 / 11 HIS A 276
GLU A 277
HIS A 280
GLU A 306
TYR A 430
 None
 0.87A 1j37B-3hoaA:
21.5		 1j37B-3hoaA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_B_X8ZB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1
(Thermus
thermophilus) 		5 / 11 HIS A 276
GLU A 277
HIS A 280
HIS A 418
TYR A 430
 None
 0.73A 1j37B-3hoaA:
21.5		 1j37B-3hoaA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1
(Thermus
thermophilus) 		5 / 12 HIS A 276
GLU A 277
HIS A 280
GLU A 306
TYR A 430
 None
 0.88A 1o86A-3hoaA:
22.1		 1o86A-3hoaA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_D_FUAD705_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1
(Thermus
thermophilus) 		5 / 12 THR A 311
SER A 307
LEU A 483
ALA A 469
HIS A 472
 None
 1.34A 1q23D-3hoaA:
0.9
1q23E-3hoaA:
undetectable		 1q23D-3hoaA:
17.13
1q23E-3hoaA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF2_0
(7-AMINO-ACTINOMYCIN
D)		 3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1
(Thermus
thermophilus) 		3 / 3 THR A 259
PRO A 246
THR A 260
 None
 0.76A 1unjF-3hoaA:
undetectable		 1unjF-3hoaA:
2.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF8_0
(7-AMINO-ACTINOMYCIN
D)		 3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1
(Thermus
thermophilus) 		3 / 3 THR A 260
THR A 259
PRO A 246
 None
 0.81A 1unjF-3hoaA:
undetectable		 1unjF-3hoaA:
2.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_F_DVAF8_0
(7-AMINOACTINOMYCIN D)		 3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1
(Thermus
thermophilus) 		3 / 3 THR A 429
THR A 431
PRO A 428
 None
 0.86A 1unmF-3hoaA:
undetectable		 1unmF-3hoaA:
2.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZEA_A_DHIA6_0
(MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
H CHAIN
MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
L CHAIN
SHORT SYNTHETIC
D-AMINO ACID PEPTIDE
D2)		 3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1
(Thermus
thermophilus) 		3 / 3 TRP A  29
ARG A  32
PHE A 247
 None
 1.40A 1zeaH-3hoaA:
undetectable
1zeaL-3hoaA:
undetectable		 1zeaH-3hoaA:
15.55
1zeaL-3hoaA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1
(Thermus
thermophilus) 		5 / 12 HIS A 276
GLU A 277
HIS A 280
GLU A 306
TYR A 430
 None
 0.93A 2c6nA-3hoaA:
21.0		 2c6nA-3hoaA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1
(Thermus
thermophilus) 		5 / 12 HIS A 276
GLU A 277
HIS A 280
GLU A 306
TYR A 430
 None
 0.97A 2c6nB-3hoaA:
21.1		 2c6nB-3hoaA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1
(Thermus
thermophilus) 		4 / 6 HIS A 280
THR A 429
TYR A 172
HIS A 276
 None
 1.43A 2dysA-3hoaA:
3.8
2dysC-3hoaA:
2.8		 2dysA-3hoaA:
22.80
2dysC-3hoaA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_P_CHDP304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1
(Thermus
thermophilus) 		4 / 6 HIS A 280
THR A 429
TYR A 172
HIS A 276
 None
 1.42A 2dysN-3hoaA:
3.6
2dysP-3hoaA:
2.8		 2dysN-3hoaA:
22.80
2dysP-3hoaA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1
(Thermus
thermophilus) 		4 / 7 HIS A 280
THR A 429
TYR A 172
HIS A 276
 None
 1.44A 2eijA-3hoaA:
3.6
2eijC-3hoaA:
2.7		 2eijA-3hoaA:
22.80
2eijC-3hoaA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1
(Thermus
thermophilus) 		4 / 7 HIS A 280
THR A 429
TYR A 172
HIS A 276
 None
 1.43A 2eilA-3hoaA:
undetectable
2eilC-3hoaA:
2.7		 2eilA-3hoaA:
22.80
2eilC-3hoaA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1
(Thermus
thermophilus) 		4 / 6 HIS A 280
THR A 429
TYR A 172
HIS A 276
 None
 1.48A 2eimN-3hoaA:
2.7
2eimP-3hoaA:
2.7		 2eimN-3hoaA:
22.80
2eimP-3hoaA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1
(Thermus
thermophilus) 		4 / 6 HIS A 280
THR A 429
TYR A 172
HIS A 276
 None
 1.41A 2einA-3hoaA:
undetectable
2einC-3hoaA:
2.7		 2einA-3hoaA:
22.80
2einC-3hoaA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X8Z_A_X8ZA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1
(Thermus
thermophilus) 		5 / 11 HIS A 276
GLU A 277
HIS A 280
GLU A 306
TYR A 430
 None
 0.91A 2x8zA-3hoaA:
21.3		 2x8zA-3hoaA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1
(Thermus
thermophilus) 		5 / 12 HIS A 276
GLU A 277
HIS A 280
GLU A 306
TYR A 430
 None
 0.89A 2x91A-3hoaA:
21.8		 2x91A-3hoaA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1
(Thermus
thermophilus) 		4 / 6 HIS A 280
THR A 429
TYR A 172
HIS A 276
 None
 1.41A 2zxwA-3hoaA:
4.0
2zxwC-3hoaA:
2.7		 2zxwA-3hoaA:
22.80
2zxwC-3hoaA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1
(Thermus
thermophilus) 		4 / 7 HIS A 280
THR A 429
TYR A 172
HIS A 276
 None
 1.43A 3abmN-3hoaA:
2.5
3abmP-3hoaA:
2.7		 3abmN-3hoaA:
22.80
3abmP-3hoaA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1
(Thermus
thermophilus) 		4 / 7 HIS A 280
THR A 429
TYR A 172
HIS A 276
 None
 1.45A 3ag3N-3hoaA:
4.4
3ag3P-3hoaA:
2.9		 3ag3N-3hoaA:
22.80
3ag3P-3hoaA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1
(Thermus
thermophilus) 		4 / 7 HIS A 280
THR A 429
TYR A 172
HIS A 276
 None
 1.47A 3ag4A-3hoaA:
undetectable
3ag4C-3hoaA:
2.7		 3ag4A-3hoaA:
22.80
3ag4C-3hoaA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1
(Thermus
thermophilus) 		5 / 12 ASN A 367
PHE A 185
THR A 365
LEU A 374
TYR A 398
 None
 1.39A 3elzA-3hoaA:
undetectable		 3elzA-3hoaA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1
(Thermus
thermophilus) 		5 / 12 TRP A 323
PHE A 223
LEU A 240
GLY A 273
GLY A 270
 None
 1.19A 3i5uA-3hoaA:
undetectable		 3i5uA-3hoaA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP9_D_SPMD230_1
(LS-24)		 3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1
(Thermus
thermophilus) 		3 / 3 GLU A 363
GLU A 306
ASN A 434
 None
 0.88A 3lp9B-3hoaA:
undetectable
3lp9D-3hoaA:
undetectable		 3lp9B-3hoaA:
17.32
3lp9D-3hoaA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1
(Thermus
thermophilus) 		4 / 7 TYR A 215
VAL A 316
VAL A 349
ARG A 325
 None
 1.22A 3ms9B-3hoaA:
undetectable		 3ms9B-3hoaA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1
(Thermus
thermophilus) 		5 / 12 LEU A 235
ALA A 224
SER A 229
LEU A 240
ALA A 219
 None
 1.35A 3ou7C-3hoaA:
undetectable		 3ou7C-3hoaA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_2
(ADENOSINE KINASE,
PUTATIVE)		 3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1
(Thermus
thermophilus) 		4 / 5 LEU A 275
GLY A 273
PHE A 223
ASN A 268
 None
 1.25A 3uq6B-3hoaA:
undetectable		 3uq6B-3hoaA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOA_A_ACRA1587_2
(TREHALOSE
SYNTHASE/AMYLASE
TRES)		 3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1
(Thermus
thermophilus) 		3 / 3 ARG A 358
PHE A 427
PRO A 428
 None
 0.89A 3zoaB-3hoaA:
undetectable		 3zoaB-3hoaA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C2P_A_X8ZA709_1
(ANGIOTENSIN-CONVERTI
NG ENZYME)		 3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1
(Thermus
thermophilus) 		6 / 11 HIS A 276
GLU A 277
HIS A 280
GLU A 306
HIS A 418
TYR A 430
 None
 0.90A 4c2pA-3hoaA:
22.0		 4c2pA-3hoaA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF2_A_4CHA506_0
(NADPH DEHYDROGENASE)		 3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1
(Thermus
thermophilus) 		4 / 6 THR A 429
TYR A 426
HIS A 280
HIS A 305
 None
 1.47A 4df2A-3hoaA:
undetectable		 4df2A-3hoaA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HIV_D_DVAD2_0
(ACTINOMYCIN D)		 3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1
(Thermus
thermophilus) 		3 / 3 THR A 259
PRO A 246
THR A 260
 None
 0.86A 4hivD-3hoaA:
undetectable		 4hivD-3hoaA:
2.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1
(Thermus
thermophilus) 		5 / 12 GLU A 502
ASP A 362
GLU A 363
LEU A 368
LEU A 192
 None
 1.29A 4pgfB-3hoaA:
undetectable		 4pgfB-3hoaA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_A_3CJA607_1
(LACTOPEROXIDASE)		 3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1
(Thermus
thermophilus) 		3 / 3 GLN A 308
HIS A 472
ARG A 468
 None
 1.08A 4qyqA-3hoaA:
0.0		 4qyqA-3hoaA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_B_3CJB607_1
(LACTOPEROXIDASE)		 3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1
(Thermus
thermophilus) 		3 / 3 GLN A 308
HIS A 472
ARG A 468
 None
 1.01A 4qyqB-3hoaA:
undetectable		 4qyqB-3hoaA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIN_H_QI9H1226_0
(FAB 314.3)		 3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1
(Thermus
thermophilus) 		5 / 12 TRP A 312
HIS A 472
THR A 467
GLY A 279
GLY A 303
 None
 1.27A 4uinH-3hoaA:
undetectable
4uinL-3hoaA:
undetectable		 4uinH-3hoaA:
16.67
4uinL-3hoaA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		 3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1
(Thermus
thermophilus) 		5 / 12 ASN A 268
GLU A 313
ARG A 310
ASP A 416
GLN A 415
 None
 1.22A 4uroB-3hoaA:
undetectable		 4uroB-3hoaA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		 3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1
(Thermus
thermophilus) 		5 / 12 ASN A 268
GLU A 313
ARG A 310
ASP A 416
GLN A 415
 None
 1.15A 4uroC-3hoaA:
undetectable		 4uroC-3hoaA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_0
(THYMIDYLATE SYNTHASE)		 3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1
(Thermus
thermophilus) 		5 / 12 PHE A 223
LEU A 464
LEU A 228
MET A 278
ALA A 281
 None
 1.12A 5fctB-3hoaA:
undetectable		 5fctB-3hoaA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JCN_B_ASCB502_0
(OS09G0567300 PROTEIN)		 3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1
(Thermus
thermophilus) 		4 / 6 PRO A 154
GLY A 175
ARG A 177
ARG A  96
 None
 1.19A 5jcnB-3hoaA:
undetectable		 5jcnB-3hoaA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_2
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1
(Thermus
thermophilus) 		3 / 3 VAL A 482
ARG A  91
PRO A 156
 None
 0.85A 5koxA-3hoaA:
undetectable		 5koxA-3hoaA:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_2
(WTFP-TAG,GP41)		 3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1
(Thermus
thermophilus) 		3 / 3 LEU A  23
LEU A  26
TRP A  29
 None
 0.88A 5nwuA-3hoaA:
undetectable		 5nwuA-3hoaA:
4.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1
(Thermus
thermophilus) 		4 / 7 GLU A 377
TYR A 165
PHE A 381
GLY A 421
 None
 0.87A 5uxdA-3hoaA:
2.4		 5uxdA-3hoaA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_2
(CYTOCHROME P450 3A5)		 3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1
(Thermus
thermophilus) 		4 / 5 ARG A 382
PHE A 427
LEU A 376
LEU A 168
 None
 1.26A 5veuH-3hoaA:
undetectable		 5veuH-3hoaA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_E_GBME2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1
(Thermus
thermophilus) 		3 / 3 LEU A 402
THR A 431
ASN A 434
 None
 0.54A 6baaE-3hoaA:
0.7		 6baaE-3hoaA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_F_GBMF2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1
(Thermus
thermophilus) 		3 / 3 LEU A 402
THR A 431
ASN A 434
 None
 0.54A 6baaF-3hoaA:
2.0		 6baaF-3hoaA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_G_GBMG2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1
(Thermus
thermophilus) 		3 / 3 LEU A 402
THR A 431
ASN A 434
 None
 0.54A 6baaG-3hoaA:
2.0		 6baaG-3hoaA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_H_GBMH2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1
(Thermus
thermophilus) 		3 / 3 LEU A 402
THR A 431
ASN A 434
 None
 0.54A 6baaH-3hoaA:
2.0		 6baaH-3hoaA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1
(Thermus
thermophilus) 		4 / 7 HIS A 280
THR A 429
TYR A 172
HIS A 276
 None
 1.45A 6nmfN-3hoaA:
undetectable
6nmfP-3hoaA:
2.9		 6nmfN-3hoaA:
22.80
6nmfP-3hoaA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_C_CHDC303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1
(Thermus
thermophilus) 		4 / 6 HIS A 280
THR A 429
TYR A 172
HIS A 276
 None
 1.43A 6nmpA-3hoaA:
undetectable
6nmpC-3hoaA:
2.7		 6nmpA-3hoaA:
22.80
6nmpC-3hoaA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_P_CHDP302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1
(Thermus
thermophilus) 		4 / 7 HIS A 280
THR A 429
TYR A 172
HIS A 276
 None
 1.42A 6nmpN-3hoaA:
undetectable
6nmpP-3hoaA:
2.8		 6nmpN-3hoaA:
22.80
6nmpP-3hoaA:
20.62