SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hoc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_2
(RETINOIC ACID
RECEPTOR, BETA)		 3hoc FILAMIN-A
(Homo
sapiens) 		3 / 3 LEU A 201
PHE A 264
ARG A 226
 None
 0.70A 1xdkB-3hocA:
undetectable		 1xdkB-3hocA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_2
(RETINOIC ACID
RECEPTOR, BETA)		 3hoc FILAMIN-A
(Homo
sapiens) 		3 / 3 LEU A 201
PHE A 264
ARG A 226
 None
 0.70A 1xdkF-3hocA:
undetectable		 1xdkF-3hocA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3hoc FILAMIN-A
(Homo
sapiens) 		5 / 12 LEU A 172
THR A 186
ILE A 185
SER A 189
PHE A 188
 None
 1.34A 1xlxA-3hocA:
undetectable		 1xlxA-3hocA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3hoc FILAMIN-A
(Homo
sapiens) 		5 / 12 LEU A 172
THR A 186
ILE A 185
SER A 189
PHE A 188
 None
 1.33A 1xomB-3hocA:
undetectable		 1xomB-3hocA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3hoc FILAMIN-A
(Homo
sapiens) 		5 / 12 LEU A 172
THR A 186
ILE A 185
SER A 189
PHE A 188
 None
 1.34A 1xoqA-3hocA:
undetectable		 1xoqA-3hocA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3hoc FILAMIN-A
(Homo
sapiens) 		5 / 12 LEU A 172
THR A 186
ILE A 185
SER A 189
PHE A 188
 None
 1.32A 1xoqB-3hocA:
undetectable		 1xoqB-3hocA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		 3hoc FILAMIN-A
(Homo
sapiens) 		4 / 4 LEU A  80
PRO A 153
ILE A 145
LEU A 144
 None
 0.85A 1ya4B-3hocA:
undetectable		 1ya4B-3hocA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		 3hoc FILAMIN-A
(Homo
sapiens) 		4 / 4 LEU A  80
PRO A 153
ILE A 145
LEU A 144
 None
 0.91A 1ya4C-3hocA:
undetectable		 1ya4C-3hocA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_B_DESB800_1
(ESTROGEN RECEPTOR
ALPHA)		 3hoc FILAMIN-A
(Homo
sapiens) 		5 / 10 ALA A 110
LEU A 121
LEU A 111
HIS A 147
LEU A 144
 None
 1.25A 3erdB-3hocA:
undetectable		 3erdB-3hocA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_A_SAMA301_0
(PUTATIVE RNA
METHYLASE)		 3hoc FILAMIN-A
(Homo
sapiens) 		5 / 12 GLY A 174
ILE A 150
SER A 151
LEU A 173
THR A 167
 None
 1.35A 4pooA-3hocA:
undetectable		 4pooA-3hocA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3hoc FILAMIN-A
(Homo
sapiens) 		3 / 3 PHE A 113
ASP A 115
LEU A 104
 None
 0.69A 5uhbC-3hocA:
undetectable		 5uhbC-3hocA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3hoc FILAMIN-A
(Homo
sapiens) 		3 / 3 PHE A 113
ASP A 115
LEU A 104
 None
 0.58A 5uhcC-3hocA:
undetectable		 5uhcC-3hocA:
13.71