SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hoi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3hoi FMN-DEPENDENT
NITROREDUCTASE
BF3017
(Bacteroides
fragilis) 		5 / 12 ILE A  91
VAL A 163
ALA A 173
GLY A  69
TYR A 102
 None
 1.21A 1kiaB-3hoiA:
undetectable		 1kiaB-3hoiA:
25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN6_A_T44A1370_1
(THYROXINE-BINDING
GLOBULIN)		 3hoi FMN-DEPENDENT
NITROREDUCTASE
BF3017
(Bacteroides
fragilis) 		5 / 10 ALA A  54
LEU A  64
LEU A 109
LEU A  95
LEU A  60
 None
 1.16A 2xn6A-3hoiA:
undetectable
2xn6B-3hoiA:
undetectable		 2xn6A-3hoiA:
20.11
2xn6B-3hoiA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN7_A_T44A1355_1
(THYROXINE-BINDING
GLOBULIN)		 3hoi FMN-DEPENDENT
NITROREDUCTASE
BF3017
(Bacteroides
fragilis) 		5 / 10 ALA A  54
LEU A  64
LEU A 109
LEU A  95
LEU A  60
 None
 1.13A 2xn7A-3hoiA:
undetectable
2xn7B-3hoiA:
undetectable		 2xn7A-3hoiA:
20.11
2xn7B-3hoiA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_0
(CATECHOL
O-METHYLTRANSFERASE)		 3hoi FMN-DEPENDENT
NITROREDUCTASE
BF3017
(Bacteroides
fragilis) 		5 / 12 VAL A  94
ASN A  68
SER A 168
GLN A 165
HIS A 205
 None
 1.49A 3bwmA-3hoiA:
undetectable		 3bwmA-3hoiA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ202_1
(PROTEIN S100-A4)		 3hoi FMN-DEPENDENT
NITROREDUCTASE
BF3017
(Bacteroides
fragilis) 		5 / 11 LEU A 109
ASP A 103
LEU A  60
SER A  61
ILE A  24
 None
 1.29A 3ko0A-3hoiA:
undetectable
3ko0B-3hoiA:
undetectable
3ko0I-3hoiA:
undetectable
3ko0J-3hoiA:
undetectable		 3ko0A-3hoiA:
19.19
3ko0B-3hoiA:
19.19
3ko0I-3hoiA:
19.19
3ko0J-3hoiA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MYU_B_VIBB500_1
(HIGH AFFINITY
TRANSPORT SYSTEM
PROTEIN P37)		 3hoi FMN-DEPENDENT
NITROREDUCTASE
BF3017
(Bacteroides
fragilis) 		5 / 10 ASN A  71
TYR A 102
ASP A 103
ILE A  70
GLY A  69
 None
 1.08A 3myuB-3hoiA:
0.0		 3myuB-3hoiA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 3hoi FMN-DEPENDENT
NITROREDUCTASE
BF3017
(Bacteroides
fragilis) 		5 / 12 VAL A  94
ASN A  68
SER A 168
GLN A 165
HIS A 205
 None
 1.49A 4xueA-3hoiA:
undetectable		 4xueA-3hoiA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_1
(MRNA CAPPING ENZYME
P5)		 3hoi FMN-DEPENDENT
NITROREDUCTASE
BF3017
(Bacteroides
fragilis) 		3 / 3 TYR A 102
ASP A  90
ASP A 103
 None
 0.82A 5x6yA-3hoiA:
undetectable		 5x6yA-3hoiA:
14.20