SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hol'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 3hol TBPB
(Actinobacillus
pleuropneumoniae) 		5 / 12 LEU A 253
PHE A 257
PHE A 280
GLY A 256
GLY A 223
 None
 1.12A 1fe2A-3holA:
undetectable		 1fe2A-3holA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_A_EAAA224_1
(GLUTATHIONE
TRANSFERASE)		 3hol TBPB
(Actinobacillus
pleuropneumoniae) 		5 / 12 TYR A 496
GLY A 494
PRO A 454
VAL A 452
PHE A 520
 None
 1.21A 1gseA-3holA:
undetectable		 1gseA-3holA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3hol TBPB
(Actinobacillus
pleuropneumoniae) 		4 / 5 PHE A 194
LEU A 207
PHE A 226
SER A 252
 None
 1.19A 1wrkB-3holA:
undetectable		 1wrkB-3holA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3hol TBPB
(Actinobacillus
pleuropneumoniae) 		4 / 6 ALA A  46
TYR A 258
TYR A 124
ILE A  71
 None
 0.97A 2dcfA-3holA:
undetectable		 2dcfA-3holA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_A_DAHA2_1
(RANASMURFIN)		 3hol TBPB
(Actinobacillus
pleuropneumoniae) 		5 / 9 ALA A 230
ALA A 232
SER A 247
SER A 250
ALA A 271
 None
 1.43A 2vh3A-3holA:
undetectable		 2vh3A-3holA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM7_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3hol TBPB
(Actinobacillus
pleuropneumoniae) 		4 / 7 ALA A  46
TYR A 258
TYR A 124
ILE A  71
 None
 0.97A 2zm7A-3holA:
undetectable		 2zm7A-3holA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM8_A_ACAA511_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3hol TBPB
(Actinobacillus
pleuropneumoniae) 		4 / 8 ALA A  46
TYR A 258
TYR A 124
ILE A  71
 None
 0.96A 2zm8A-3holA:
undetectable		 2zm8A-3holA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3hol TBPB
(Actinobacillus
pleuropneumoniae) 		4 / 8 ALA A  46
TYR A 258
TYR A 124
ILE A  71
 None
 0.99A 2zmaA-3holA:
undetectable		 2zmaA-3holA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 3hol TBPB
(Actinobacillus
pleuropneumoniae) 		5 / 11 GLY A 361
ASP A 402
ALA A 415
THR A 414
ALA A 348
 None
 1.02A 3g88A-3holA:
undetectable		 3g88A-3holA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 3hol TBPB
(Actinobacillus
pleuropneumoniae) 		5 / 11 GLY A 361
ASP A 402
ALA A 415
THR A 414
ALA A 348
 None
 1.03A 3g88B-3holA:
undetectable		 3g88B-3holA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 3hol TBPB
(Actinobacillus
pleuropneumoniae) 		5 / 12 GLY A 361
ASP A 402
ALA A 415
THR A 414
ALA A 348
 None
 1.05A 3g89A-3holA:
undetectable		 3g89A-3holA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 3hol TBPB
(Actinobacillus
pleuropneumoniae) 		5 / 11 GLY A 361
ASP A 402
ALA A 415
THR A 414
ALA A 348
 None
 1.04A 3g89B-3holA:
undetectable		 3g89B-3holA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 3hol TBPB
(Actinobacillus
pleuropneumoniae) 		5 / 12 GLY A 361
ASP A 402
ALA A 415
THR A 414
ALA A 348
 None
 1.06A 3g8bA-3holA:
undetectable		 3g8bA-3holA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 3hol TBPB
(Actinobacillus
pleuropneumoniae) 		5 / 12 GLY A 361
ASP A 402
ALA A 415
THR A 414
ALA A 348
 None
 1.07A 3g8bB-3holA:
undetectable		 3g8bB-3holA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_D_T1CD401_1
(TETX2 PROTEIN)		 3hol TBPB
(Actinobacillus
pleuropneumoniae) 		5 / 10 ASP A 457
PHE A 431
ASN A 435
GLY A 393
GLY A 458
 None
 1.36A 3v3oD-3holA:
undetectable		 3v3oD-3holA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_C_Y70C151_1
(CEREBLON ISOFORM 4)		 3hol TBPB
(Actinobacillus
pleuropneumoniae) 		4 / 8 PHE A 450
PHE A 441
TRP A 401
TRP A 411
 None
 1.48A 4v2zC-3holA:
undetectable		 4v2zC-3holA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YSH_B_GLYB401_0
(GLYCINE OXIDASE)		 3hol TBPB
(Actinobacillus
pleuropneumoniae) 		4 / 6 GLY A 126
TYR A 124
ALA A 266
ARG A 225
 None
 1.29A 4yshB-3holA:
undetectable		 4yshB-3holA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA303_1
(CHITOSANASE)		 3hol TBPB
(Actinobacillus
pleuropneumoniae) 		4 / 5 ASP A 182
VAL A  55
GLY A 173
ALA A 151
 None
 0.95A 5hwaA-3holA:
undetectable		 5hwaA-3holA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3hol TBPB
(Actinobacillus
pleuropneumoniae) 		4 / 6 TYR A 215
ASP A 273
ILE A  65
TYR A 243
 None
 1.11A 5igyA-3holA:
undetectable		 5igyA-3holA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3hol TBPB
(Actinobacillus
pleuropneumoniae) 		4 / 6 TYR A 215
ASP A 273
ILE A  65
TYR A 243
 None
 1.19A 5ih0A-3holA:
undetectable		 5ih0A-3holA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_I_BEZI1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 3hol TBPB
(Actinobacillus
pleuropneumoniae) 		3 / 3 SER A 105
TYR A 124
TYR A 123
 None
 0.57A 5lakA-3holA:
undetectable
5lakI-3holA:
undetectable		 5lakA-3holA:
21.36
5lakI-3holA:
3.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_J_BEZJ1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 3hol TBPB
(Actinobacillus
pleuropneumoniae) 		3 / 3 SER A 105
TYR A 124
TYR A 123
 None
 0.58A 5lakC-3holA:
undetectable
5lakJ-3holA:
undetectable		 5lakC-3holA:
21.36
5lakJ-3holA:
3.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3hol TBPB
(Actinobacillus
pleuropneumoniae) 		4 / 5 TYR A 215
SER A 247
ALA A 248
GLN A 251
 None
 1.26A 5n0tA-3holA:
undetectable		 5n0tA-3holA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_0
(REGULATORY PROTEIN
TETR)		 3hol TBPB
(Actinobacillus
pleuropneumoniae) 		5 / 12 ALA A 271
GLU A 254
LEU A  42
ILE A  68
TYR A 124
 None
 1.41A 5vlmE-3holA:
undetectable		 5vlmE-3holA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA608_0
(ALPHA-AMYLASE)		 3hol TBPB
(Actinobacillus
pleuropneumoniae) 		4 / 6 PHE A 461
GLY A 494
GLN A 506
TYR A 496
 None
 1.15A 6ag0A-3holA:
undetectable		 6ag0A-3holA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC606_0
(ALPHA-AMYLASE)		 3hol TBPB
(Actinobacillus
pleuropneumoniae) 		4 / 6 PHE A 461
GLY A 494
GLN A 506
TYR A 496
 None
 1.14A 6ag0C-3holA:
undetectable		 6ag0C-3holA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3hol TBPB
(Actinobacillus
pleuropneumoniae) 		3 / 3 ARG A 383
PHE A 360
PHE A 461
 None
 1.00A 6nknC-3holA:
undetectable
6nknJ-3holA:
undetectable		 6nknC-3holA:
18.40
6nknJ-3holA:
7.43