SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hp0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_U_9CRU502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3hp0 PUTATIVE POLYKETIDE
BIOSYNTHESIS
ENOYL-COA HYDRATASE
HOMOLOG PKSH
(Bacillus
subtilis) 		5 / 12 ALA A 125
VAL A  11
ILE A   9
CYH A  39
LEU A  43
 None
 0.94A 1fm6U-3hp0A:
undetectable		 1fm6U-3hp0A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1217_1
(LIPOPROTEIN LPPX)		 3hp0 PUTATIVE POLYKETIDE
BIOSYNTHESIS
ENOYL-COA HYDRATASE
HOMOLOG PKSH
(Bacillus
subtilis) 		4 / 4 VAL A 111
LEU A  92
ILE A  36
LEU A  35
 None
 0.96A 2byoA-3hp0A:
undetectable		 2byoA-3hp0A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_D_BEZD1221_0
(PEROXIREDOXIN 6)		 3hp0 PUTATIVE POLYKETIDE
BIOSYNTHESIS
ENOYL-COA HYDRATASE
HOMOLOG PKSH
(Bacillus
subtilis) 		4 / 8 VAL A 102
THR A  52
VAL A  17
SER A  16
 None
 0.93A 2v32C-3hp0A:
undetectable
2v32D-3hp0A:
undetectable		 2v32C-3hp0A:
22.66
2v32D-3hp0A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3hp0 PUTATIVE POLYKETIDE
BIOSYNTHESIS
ENOYL-COA HYDRATASE
HOMOLOG PKSH
(Bacillus
subtilis) 		4 / 5 LEU A  56
GLN A  97
THR A 122
LEU A  89
 None
 1.13A 3ce6D-3hp0A:
undetectable		 3ce6D-3hp0A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 3hp0 PUTATIVE POLYKETIDE
BIOSYNTHESIS
ENOYL-COA HYDRATASE
HOMOLOG PKSH
(Bacillus
subtilis) 		5 / 12 LEU A  89
GLY A 115
GLY A 117
SER A 132
ALA A  67
 None
 1.09A 3i5uB-3hp0A:
undetectable		 3i5uB-3hp0A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OAP_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3hp0 PUTATIVE POLYKETIDE
BIOSYNTHESIS
ENOYL-COA HYDRATASE
HOMOLOG PKSH
(Bacillus
subtilis) 		5 / 12 ALA A 125
VAL A  11
ILE A   9
CYH A  39
LEU A  43
 None
 0.89A 3oapA-3hp0A:
undetectable		 3oapA-3hp0A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3hp0 PUTATIVE POLYKETIDE
BIOSYNTHESIS
ENOYL-COA HYDRATASE
HOMOLOG PKSH
(Bacillus
subtilis) 		5 / 12 ALA A 121
PHE A 118
ILE A   9
CYH A  39
LEU A  43
 None
 1.19A 3uvvB-3hp0A:
undetectable		 3uvvB-3hp0A:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K38_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME
KP18CYS PEPTIDE)		 3hp0 PUTATIVE POLYKETIDE
BIOSYNTHESIS
ENOYL-COA HYDRATASE
HOMOLOG PKSH
(Bacillus
subtilis) 		5 / 12 GLN A  41
VAL A  11
ILE A   9
LEU A  56
CYH A  39
 None
 1.44A 4k38A-3hp0A:
undetectable
4k38D-3hp0A:
undetectable		 4k38A-3hp0A:
20.00
4k38D-3hp0A:
6.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGW_A_CTYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3hp0 PUTATIVE POLYKETIDE
BIOSYNTHESIS
ENOYL-COA HYDRATASE
HOMOLOG PKSH
(Bacillus
subtilis) 		5 / 12 GLY A 156
SER A 171
ILE A 170
PHE A 133
MET A 163
 None
 1.44A 5igwA-3hp0A:
undetectable		 5igwA-3hp0A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3hp0 PUTATIVE POLYKETIDE
BIOSYNTHESIS
ENOYL-COA HYDRATASE
HOMOLOG PKSH
(Bacillus
subtilis) 		5 / 12 GLY A 156
SER A 171
ILE A 170
PHE A 133
MET A 163
 None
 1.16A 5igyA-3hp0A:
undetectable		 5igyA-3hp0A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3hp0 PUTATIVE POLYKETIDE
BIOSYNTHESIS
ENOYL-COA HYDRATASE
HOMOLOG PKSH
(Bacillus
subtilis) 		5 / 12 GLY A 156
SER A 171
ILE A 170
PHE A 133
MET A 163
 None
 1.04A 5ih0A-3hp0A:
undetectable		 5ih0A-3hp0A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3hp0 PUTATIVE POLYKETIDE
BIOSYNTHESIS
ENOYL-COA HYDRATASE
HOMOLOG PKSH
(Bacillus
subtilis) 		5 / 12 ALA A 226
PHE A  22
ILE A   9
PHE A 118
THR A 103
 None
 1.33A 5jlcA-3hp0A:
undetectable		 5jlcA-3hp0A:
18.57