SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hpd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 3hpd HYDROXYETHYLTHIAZOLE
KINASE
(Pyrococcus
horikoshii) 		5 / 12 ILE A  64
LEU A 107
SER A 125
ILE A 124
LEU A 117
 None
 0.66A 1ddrA-3hpdA:
undetectable		 1ddrA-3hpdA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 3hpd HYDROXYETHYLTHIAZOLE
KINASE
(Pyrococcus
horikoshii) 		5 / 12 ILE A  64
LEU A 107
SER A 125
ILE A 124
LEU A 117
 None
 0.97A 1ddsB-3hpdA:
undetectable		 1ddsB-3hpdA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3hpd HYDROXYETHYLTHIAZOLE
KINASE
(Pyrococcus
horikoshii) 		5 / 12 ILE A  64
LEU A 107
SER A 125
ILE A 124
LEU A 117
 None
 0.71A 1dhiA-3hpdA:
undetectable		 1dhiA-3hpdA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3hpd HYDROXYETHYLTHIAZOLE
KINASE
(Pyrococcus
horikoshii) 		5 / 12 ILE A  64
LEU A 107
SER A 125
ILE A 124
LEU A 117
 None
 0.75A 1dhjA-3hpdA:
undetectable		 1dhjA-3hpdA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3hpd HYDROXYETHYLTHIAZOLE
KINASE
(Pyrococcus
horikoshii) 		5 / 12 ILE A  64
LEU A 107
SER A 125
ILE A 124
LEU A 117
 None
 0.72A 1draA-3hpdA:
undetectable		 1draA-3hpdA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3hpd HYDROXYETHYLTHIAZOLE
KINASE
(Pyrococcus
horikoshii) 		5 / 12 ILE A  64
LEU A 107
SER A 125
ILE A 124
LEU A 117
 None
 0.74A 1drbA-3hpdA:
undetectable		 1drbA-3hpdA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4004_1
(SERUM ALBUMIN)		 3hpd HYDROXYETHYLTHIAZOLE
KINASE
(Pyrococcus
horikoshii) 		4 / 4 VAL A 260
PHE A   3
SER A 216
VAL A 219
 None
 1.41A 1e7cA-3hpdA:
1.9		 1e7cA-3hpdA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FPQ_A_SAMA1699_0
(ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE)		 3hpd HYDROXYETHYLTHIAZOLE
KINASE
(Pyrococcus
horikoshii) 		5 / 10 GLY A 194
ASN A  63
LEU A 187
VAL A 190
ALA A 199
 PO4  A 300 (-3.1A)
None
None
None
None
 1.49A 1fpqA-3hpdA:
4.7		 1fpqA-3hpdA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3hpd HYDROXYETHYLTHIAZOLE
KINASE
(Pyrococcus
horikoshii) 		5 / 12 ILE A  64
LEU A 107
SER A 125
ILE A 124
LEU A 117
 None
 0.88A 1rh3A-3hpdA:
undetectable		 1rh3A-3hpdA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9Q_A_CHDA459_0
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 3hpd HYDROXYETHYLTHIAZOLE
KINASE
(Pyrococcus
horikoshii) 		4 / 6 ASP A  92
LEU A  91
VAL A  90
ILE A  89
 None
 1.01A 1s9qA-3hpdA:
undetectable		 1s9qA-3hpdA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_B_STRB402_1
(MINERALOCORTICOID
RECEPTOR)		 3hpd HYDROXYETHYLTHIAZOLE
KINASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A  34
ALA A  39
LEU A 246
LEU A   8
THR A 208
 None
 1.28A 2aa6B-3hpdA:
undetectable		 2aa6B-3hpdA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3hpd HYDROXYETHYLTHIAZOLE
KINASE
(Pyrococcus
horikoshii) 		5 / 12 ILE A  64
LEU A 107
SER A 125
ILE A 124
LEU A 117
 None
 0.73A 2drcA-3hpdA:
undetectable		 2drcA-3hpdA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOA_A_3TCA302_1
(DEOXYCYTIDINE KINASE)		 3hpd HYDROXYETHYLTHIAZOLE
KINASE
(Pyrococcus
horikoshii) 		5 / 12 ILE A 249
LEU A 200
ALA A  39
ARG A  15
ARG A  12
 None
 1.38A 2noaA-3hpdA:
2.1		 2noaA-3hpdA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOA_B_3TCB302_1
(DEOXYCYTIDINE KINASE)		 3hpd HYDROXYETHYLTHIAZOLE
KINASE
(Pyrococcus
horikoshii) 		5 / 11 ILE A 249
LEU A 200
ALA A  39
ARG A  15
ARG A  12
 None
 1.39A 2noaB-3hpdA:
2.7		 2noaB-3hpdA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_1
(MINERALOCORTICOID
RECEPTOR)		 3hpd HYDROXYETHYLTHIAZOLE
KINASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A  34
ALA A  39
LEU A 246
LEU A   8
THR A 208
 None
 1.31A 2oaxF-3hpdA:
undetectable		 2oaxF-3hpdA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_1
(ESTROGEN RECEPTOR)		 3hpd HYDROXYETHYLTHIAZOLE
KINASE
(Pyrococcus
horikoshii) 		5 / 12 THR A 201
ALA A 213
LEU A 211
ARG A  10
ILE A 249
 None
 1.14A 2qxsB-3hpdA:
undetectable		 2qxsB-3hpdA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_C_X2NC1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3hpd HYDROXYETHYLTHIAZOLE
KINASE
(Pyrococcus
horikoshii) 		5 / 12 VAL A  26
ALA A 228
ALA A 224
THR A 220
LEU A 200
 None
 1.30A 2x2nC-3hpdA:
undetectable		 2x2nC-3hpdA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 3hpd HYDROXYETHYLTHIAZOLE
KINASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 119
ALA A  96
VAL A  90
LEU A  91
LEU A 110
 None
 0.89A 2yqzA-3hpdA:
4.4		 2yqzA-3hpdA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 3hpd HYDROXYETHYLTHIAZOLE
KINASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 119
ALA A  96
VAL A  90
LEU A  91
LEU A 110
 None
 0.90A 2yqzB-3hpdA:
4.5		 2yqzB-3hpdA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_E_VDYE6178_1
(VITAMIN D
HYDROXYLASE)		 3hpd HYDROXYETHYLTHIAZOLE
KINASE
(Pyrococcus
horikoshii) 		5 / 12 ILE A 124
ALA A 155
THR A 160
VAL A 114
LEU A 110
 None
 1.17A 3a51E-3hpdA:
undetectable		 3a51E-3hpdA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_B_VD3B700_1
(CYTOCHROME P450 2R1)		 3hpd HYDROXYETHYLTHIAZOLE
KINASE
(Pyrococcus
horikoshii) 		5 / 12 ALA A 154
GLY A 166
THR A 214
VAL A 116
THR A 161
 None
 1.12A 3c6gB-3hpdA:
undetectable		 3c6gB-3hpdA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3hpd HYDROXYETHYLTHIAZOLE
KINASE
(Pyrococcus
horikoshii) 		5 / 12 ILE A  64
LEU A 107
SER A 125
ILE A 124
LEU A 117
 None
 0.74A 3drcA-3hpdA:
undetectable		 3drcA-3hpdA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_1
(PROTEASE)		 3hpd HYDROXYETHYLTHIAZOLE
KINASE
(Pyrococcus
horikoshii) 		6 / 10 LEU A 150
ALA A 155
ASP A 173
VAL A 171
LEU A 110
VAL A 164
 None
 1.43A 3em3A-3hpdA:
undetectable		 3em3A-3hpdA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_1
(DIHYDROFOLATE
REDUCTASE)		 3hpd HYDROXYETHYLTHIAZOLE
KINASE
(Pyrococcus
horikoshii) 		5 / 12 ILE A  64
LEU A 107
SER A 125
ILE A 124
LEU A 117
 None
 0.98A 3ia4D-3hpdA:
2.2		 3ia4D-3hpdA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_D_TPFD490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 3hpd HYDROXYETHYLTHIAZOLE
KINASE
(Pyrococcus
horikoshii) 		4 / 8 ALA A 228
ALA A 224
THR A 220
LEU A 200
 None
 1.06A 3l4dD-3hpdA:
undetectable		 3l4dD-3hpdA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ9_A_MTXA2001_1
(DIHYDROFOLATE
REDUCTASE)		 3hpd HYDROXYETHYLTHIAZOLE
KINASE
(Pyrococcus
horikoshii) 		5 / 12 ILE A  64
LEU A 107
SER A 125
ILE A 124
LEU A 117
 None
 0.92A 3tq9A-3hpdA:
undetectable		 3tq9A-3hpdA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 3hpd HYDROXYETHYLTHIAZOLE
KINASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A 187
LEU A  37
LEU A 246
TYR A 243
ALA A 203
 None
 1.02A 3vw7A-3hpdA:
undetectable		 3vw7A-3hpdA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3hpd HYDROXYETHYLTHIAZOLE
KINASE
(Pyrococcus
horikoshii) 		5 / 12 ILE A  54
LEU A  67
ILE A  89
ILE A 109
VAL A 105
 None
 1.08A 3w67B-3hpdA:
undetectable		 3w67B-3hpdA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		 3hpd HYDROXYETHYLTHIAZOLE
KINASE
(Pyrococcus
horikoshii) 		4 / 7 LEU A 246
THR A  29
ALA A  33
LEU A  37
 None
 0.89A 4d7bA-3hpdA:
undetectable		 4d7bA-3hpdA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3hpd HYDROXYETHYLTHIAZOLE
KINASE
(Pyrococcus
horikoshii) 		5 / 12 ILE A  64
LEU A 107
SER A 125
ILE A 124
LEU A 117
 None
 0.76A 4dfrA-3hpdA:
undetectable		 4dfrA-3hpdA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3hpd HYDROXYETHYLTHIAZOLE
KINASE
(Pyrococcus
horikoshii) 		5 / 12 ILE A  64
LEU A 107
SER A 125
ILE A 124
LEU A 117
 None
 1.09A 4gh8A-3hpdA:
undetectable		 4gh8A-3hpdA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_B_LURB201_1
(TRANSTHYRETIN)		 3hpd HYDROXYETHYLTHIAZOLE
KINASE
(Pyrococcus
horikoshii) 		4 / 8 LEU A 246
THR A  29
ALA A  33
LEU A  37
 None
 0.74A 4iizB-3hpdA:
undetectable		 4iizB-3hpdA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3hpd HYDROXYETHYLTHIAZOLE
KINASE
(Pyrococcus
horikoshii) 		5 / 12 ILE A  64
LEU A 107
SER A 125
ILE A 124
LEU A 117
 None
 0.82A 4qi9A-3hpdA:
undetectable		 4qi9A-3hpdA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 3hpd HYDROXYETHYLTHIAZOLE
KINASE
(Pyrococcus
horikoshii) 		5 / 12 ILE A  64
LEU A 107
SER A 125
ILE A 124
LEU A 117
 None
 0.73A 4qi9B-3hpdA:
2.3		 4qi9B-3hpdA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3hpd HYDROXYETHYLTHIAZOLE
KINASE
(Pyrococcus
horikoshii) 		5 / 11 ILE A  64
LEU A 107
SER A 125
ILE A 124
LEU A 117
 None
 0.75A 4qleB-3hpdA:
undetectable		 4qleB-3hpdA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3hpd HYDROXYETHYLTHIAZOLE
KINASE
(Pyrococcus
horikoshii) 		5 / 12 ILE A  64
LEU A 107
SER A 125
ILE A 124
LEU A 117
 None
 0.89A 5hi6A-3hpdA:
undetectable		 5hi6A-3hpdA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OTR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 3hpd HYDROXYETHYLTHIAZOLE
KINASE
(Pyrococcus
horikoshii) 		4 / 5 VAL A  90
ASP A  92
PRO A  93
ALA A 198
 None
 1.07A 5otrA-3hpdA:
undetectable		 5otrA-3hpdA:
21.23