SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hpe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 3hpe CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		6 / 12 LEU A  84
ILE A  70
ILE A  73
PHE A  90
VAL A 171
VAL A  33
 ERU  A 301 ( 4.8A)
None
None
ERU  A 301 (-4.8A)
ERU  A 301 ( 4.8A)
None
 1.31A 2ygoA-3hpeA:
undetectable		 2ygoA-3hpeA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RMJ_A_NCAA402_0
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2)		 3hpe CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		4 / 7 LEU A 116
ASN A 152
ILE A 151
ASP A 155
 None
 0.83A 4rmjA-3hpeA:
undetectable		 4rmjA-3hpeA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3hpe CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		4 / 6 PHE A  64
TYR A 105
MET A 143
ILE A 129
 ERU  A 301 ( 4.5A)
None
None
None
 1.25A 5iwuA-3hpeA:
undetectable		 5iwuA-3hpeA:
19.22