SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hpg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 3hpg INTEGRASE
(Visna-maedi
virus) 		5 / 10 MET A 132
ALA A 125
ALA A 122
LEU A  76
VAL A  65
 None
 1.25A 2wuzA-3hpgA:
undetectable		 2wuzA-3hpgA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_B_QMRB1214_1
(CAPITELLA TELETA
ACHBP)		 3hpg INTEGRASE
(Visna-maedi
virus) 		5 / 9 ILE A  86
PHE A 123
PHE A  99
TRP A  78
TYR A  67
 None
 1.49A 4afgA-3hpgA:
undetectable
4afgE-3hpgA:
undetectable		 4afgA-3hpgA:
18.18
4afgE-3hpgA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_A_MZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		 3hpg INTEGRASE
(Visna-maedi
virus) 		5 / 12 ASP A 118
HIS A 139
VAL A  65
THR A 103
TRP A  78
 None
 1.38A 4yhaA-3hpgA:
undetectable		 4yhaA-3hpgA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3hpg INTEGRASE
(Visna-maedi
virus) 		4 / 7 THR A 159
LEU A 160
THR A 184
THR A 163
 None
 0.93A 4z90A-3hpgA:
undetectable
4z90B-3hpgA:
undetectable
4z90C-3hpgA:
undetectable
4z90D-3hpgA:
undetectable
4z90E-3hpgA:
undetectable		 4z90A-3hpgA:
18.58
4z90B-3hpgA:
18.58
4z90C-3hpgA:
18.58
4z90D-3hpgA:
18.58
4z90E-3hpgA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3hpg INTEGRASE
(Visna-maedi
virus) 		4 / 7 THR A 159
LEU A 160
THR A 184
THR A 163
 None
 0.96A 4z91F-3hpgA:
undetectable
4z91G-3hpgA:
undetectable
4z91H-3hpgA:
undetectable
4z91I-3hpgA:
undetectable
4z91J-3hpgA:
undetectable		 4z91F-3hpgA:
18.58
4z91G-3hpgA:
18.58
4z91H-3hpgA:
18.58
4z91I-3hpgA:
18.58
4z91J-3hpgA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3hpg INTEGRASE
(Visna-maedi
virus) 		4 / 7 THR A 184
THR A 163
THR A 159
LEU A 160
 None
 0.90A 4z91F-3hpgA:
undetectable
4z91G-3hpgA:
undetectable
4z91H-3hpgA:
undetectable
4z91I-3hpgA:
undetectable
4z91J-3hpgA:
undetectable		 4z91F-3hpgA:
18.58
4z91G-3hpgA:
18.58
4z91H-3hpgA:
18.58
4z91I-3hpgA:
18.58
4z91J-3hpgA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_A_GCSA407_1
(PREDICTED
ACETYLTRANSFERASE)		 3hpg INTEGRASE
(Visna-maedi
virus) 		4 / 8 GLU A  94
GLY A 120
PRO A 121
ASP A 118
 None
 1.07A 5kgpA-3hpgA:
undetectable		 5kgpA-3hpgA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_B_GCSB405_1
(PREDICTED
ACETYLTRANSFERASE)		 3hpg INTEGRASE
(Visna-maedi
virus) 		4 / 8 GLU A  94
GLY A 120
PRO A 121
ASP A 118
 None
 1.07A 5kgpB-3hpgA:
undetectable		 5kgpB-3hpgA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_D_SAMD501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 3hpg INTEGRASE
(Visna-maedi
virus) 		5 / 10 LEU A  22
HIS A  23
ILE A  36
LEU A   7
ALA A   8
 None
 1.03A 5o96C-3hpgA:
undetectable
5o96D-3hpgA:
undetectable		 5o96C-3hpgA:
21.34
5o96D-3hpgA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGJ_A_ACTA307_0
(CARBONIC ANHYDRASE
13)		 3hpg INTEGRASE
(Visna-maedi
virus) 		4 / 6 HIS A 139
VAL A  65
THR A 103
TRP A  78
 None
 1.33A 5ogjA-3hpgA:
undetectable		 5ogjA-3hpgA:
25.37