SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hqf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_2
(RETINOIC ACID
RECEPTOR, BETA)		 3hqf RESTRICTION
ENDONUCLEASE
(Escherichia
coli) 		3 / 3 LEU A  50
PHE A 122
ARG A  98
 None
 0.86A 1xdkB-3hqfA:
undetectable		 1xdkB-3hqfA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 3hqf RESTRICTION
ENDONUCLEASE
(Escherichia
coli) 		3 / 3 ALA A  80
GLY A  39
SER A 106
 None
 0.60A 2ivuA-3hqfA:
undetectable		 2ivuA-3hqfA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		 3hqf RESTRICTION
ENDONUCLEASE
(Escherichia
coli) 		4 / 7 ILE A 136
ARG A  98
ILE A  42
PHE A 122
 None
 1.14A 2q6hA-3hqfA:
undetectable		 2q6hA-3hqfA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		 3hqf RESTRICTION
ENDONUCLEASE
(Escherichia
coli) 		4 / 8 LEU A 120
ALA A 116
LEU A  25
ILE A  13
 None
 0.88A 3cldB-3hqfA:
undetectable		 3cldB-3hqfA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QJ7_A_SPMA264_1
(THYMIDYLATE SYNTHASE)		 3hqf RESTRICTION
ENDONUCLEASE
(Escherichia
coli) 		4 / 8 ALA A  82
LEU A  66
ASP A 130
SER A  53
 None
 0.93A 3qj7A-3hqfA:
undetectable
3qj7D-3hqfA:
undetectable		 3qj7A-3hqfA:
19.70
3qj7D-3hqfA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OQR_A_2UOA502_1
(CYP105AS1)		 3hqf RESTRICTION
ENDONUCLEASE
(Escherichia
coli) 		5 / 9 TRP A   9
ILE A  13
VAL A  20
ALA A 165
ALA A 151
 None
 1.23A 4oqrA-3hqfA:
undetectable		 4oqrA-3hqfA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_C_QDNC602_1
(CYTOCHROME P450 2D6)		 3hqf RESTRICTION
ENDONUCLEASE
(Escherichia
coli) 		5 / 11 GLY A  39
LEU A  40
GLN A  37
ALA A  27
SER A  26
 None
 1.08A 4wnuC-3hqfA:
undetectable		 4wnuC-3hqfA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZOW_A_CLMA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 3hqf RESTRICTION
ENDONUCLEASE
(Escherichia
coli) 		5 / 11 TYR A  21
LEU A  25
LEU A 108
ILE A 136
LEU A  66
 None
 0.99A 4zowA-3hqfA:
undetectable		 4zowA-3hqfA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 3hqf RESTRICTION
ENDONUCLEASE
(Escherichia
coli) 		3 / 3 ASN A 135
TYR A  18
CYH A 131
 None
 1.02A 5lsuB-3hqfA:
undetectable		 5lsuB-3hqfA:
22.57