SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hqg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_A_EAAA223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 3hqg TYPE-2 RESTRICTION
ENZYME ECORII
(Escherichia
coli) 		4 / 8 PHE A 278
GLY A 282
ARG A 284
PHE A 286
 None
 0.82A 1gsfA-3hqgA:
2.3		 1gsfA-3hqgA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_B_EAAB223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 3hqg TYPE-2 RESTRICTION
ENZYME ECORII
(Escherichia
coli) 		4 / 8 PHE A 278
GLY A 282
ARG A 284
PHE A 286
 None
 0.82A 1gsfB-3hqgA:
2.3		 1gsfB-3hqgA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_C_EAAC223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 3hqg TYPE-2 RESTRICTION
ENZYME ECORII
(Escherichia
coli) 		4 / 8 PHE A 278
GLY A 282
ARG A 284
PHE A 286
 None
 0.82A 1gsfC-3hqgA:
2.3		 1gsfC-3hqgA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_D_EAAD223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 3hqg TYPE-2 RESTRICTION
ENZYME ECORII
(Escherichia
coli) 		4 / 8 PHE A 278
GLY A 282
ARG A 284
PHE A 286
 None
 0.83A 1gsfD-3hqgA:
2.3		 1gsfD-3hqgA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3hqg TYPE-2 RESTRICTION
ENZYME ECORII
(Escherichia
coli) 		5 / 12 LEU A 270
VAL A 323
PHE A 278
PHE A 286
PHE A 392
 None
 0.95A 4iaqA-3hqgA:
2.6		 4iaqA-3hqgA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K13_A_ETSA304_1
(CARBONIC ANHYDRASE 2)		 3hqg TYPE-2 RESTRICTION
ENZYME ECORII
(Escherichia
coli) 		5 / 12 HIS A 375
LEU A 270
LEU A 218
LEU A 389
THR A 388
 None
 0.99A 4k13A-3hqgA:
undetectable		 4k13A-3hqgA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA407_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 3hqg TYPE-2 RESTRICTION
ENZYME ECORII
(Escherichia
coli) 		3 / 3 GLU A 225
ARG A 222
HIS A 273
 None
 0.85A 4kf9A-3hqgA:
undetectable		 4kf9A-3hqgA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_A_BEZA502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 3hqg TYPE-2 RESTRICTION
ENZYME ECORII
(Escherichia
coli) 		4 / 6 PHE A 278
VAL A 369
LEU A 270
LEU A 274
 None
 1.01A 6e43A-3hqgA:
undetectable		 6e43A-3hqgA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_B_BEZB502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 3hqg TYPE-2 RESTRICTION
ENZYME ECORII
(Escherichia
coli) 		4 / 6 PHE A 278
VAL A 369
LEU A 270
LEU A 274
 None
 1.03A 6e43B-3hqgA:
undetectable		 6e43B-3hqgA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_C_BEZC502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 3hqg TYPE-2 RESTRICTION
ENZYME ECORII
(Escherichia
coli) 		4 / 6 PHE A 278
VAL A 369
LEU A 270
LEU A 274
 None
 1.01A 6e43C-3hqgA:
undetectable		 6e43C-3hqgA:
20.63