SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hqm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1874_0
(FPRA)		 3hqm SPECKLE-TYPE POZ
PROTEIN
(Homo
sapiens) 		4 / 5 TRP A 131
ALA A 122
PHE A 102
SER A 119
 None
 1.19A 1lqtB-3hqmA:
0.0		 1lqtB-3hqmA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_A_9CRA131_1
(TRANSTHYRETIN)		 3hqm SPECKLE-TYPE POZ
PROTEIN
(Homo
sapiens) 		4 / 6 LEU A  88
LEU A  69
SER A  54
THR A  56
 None
None
SO4  A   4 (-4.4A)
None
 1.12A 1tyrA-3hqmA:
undetectable		 1tyrA-3hqmA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_D_TFPD207_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3hqm SPECKLE-TYPE POZ
PROTEIN
(Homo
sapiens) 		4 / 8 LEU A  84
PHE A 102
PHE A 104
SER A  54
 None
None
None
SO4  A   4 (-4.4A)
 1.03A 1wrlC-3hqmA:
undetectable
1wrlD-3hqmA:
undetectable		 1wrlC-3hqmA:
17.45
1wrlD-3hqmA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_A_SUZA201_1
(TRANSTHYRETIN)		 3hqm SPECKLE-TYPE POZ
PROTEIN
(Homo
sapiens) 		4 / 7 LEU A  88
LEU A  69
SER A  54
THR A  56
 None
None
SO4  A   4 (-4.4A)
None
 1.14A 4iklA-3hqmA:
undetectable
4iklB-3hqmA:
undetectable		 4iklA-3hqmA:
22.50
4iklB-3hqmA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P7N_A_GCSA702_1
(POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE)		 3hqm SPECKLE-TYPE POZ
PROTEIN
(Homo
sapiens) 		3 / 3 ASP A 130
TYR A  87
TRP A 131
 None
 1.36A 4p7nA-3hqmA:
undetectable		 4p7nA-3hqmA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NKN_A_LOCA201_1
(NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN)		 3hqm SPECKLE-TYPE POZ
PROTEIN
(Homo
sapiens) 		5 / 12 GLY A 132
PHE A 104
PHE A  32
PHE A 102
ASP A 130
 None
 1.33A 5nknA-3hqmA:
undetectable		 5nknA-3hqmA:
19.72