SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hr0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_B_ESTB354_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 3hr0 COG4
(Homo
sapiens) 		4 / 8 VAL A 620
LEU A 656
MET A 660
VAL A 718
 None
 1.01A 1fduB-3hr0A:
undetectable		 1fduB-3hr0A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTV_A_TESA500_1
(17
BETA-HYDROXYSTEROID
DEHYDROGENASE TYPE 1)		 3hr0 COG4
(Homo
sapiens) 		4 / 8 HIS A 632
SER A 631
VAL A 630
GLU A 707
 None
 1.01A 1jtvA-3hr0A:
undetectable		 1jtvA-3hr0A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U1J_A_C2FA773_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 3hr0 COG4
(Homo
sapiens) 		4 / 8 HIS A 632
SER A 694
VAL A 690
TRP A 648
 None
 1.16A 1u1jA-3hr0A:
undetectable		 1u1jA-3hr0A:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_0
(ESTROGEN RECEPTOR)		 3hr0 COG4
(Homo
sapiens) 		5 / 12 LEU A 675
LEU A 678
MET A 679
LEU A 682
LEU A 545
 None
 0.72A 2ouzA-3hr0A:
undetectable		 2ouzA-3hr0A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQ5_B_LDPB1197_1
(S-NORCOCLAURINE
SYNTHASE)		 3hr0 COG4
(Homo
sapiens) 		4 / 7 LEU A 711
LEU A 715
PHE A 727
LEU A 687
 None
 0.93A 2vq5B-3hr0A:
undetectable		 2vq5B-3hr0A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3hr0 COG4
(Homo
sapiens) 		4 / 7 ILE A 634
GLU A 707
GLY A 701
GLY A 700
 None
 0.86A 5a06E-3hr0A:
undetectable		 5a06E-3hr0A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3hr0 COG4
(Homo
sapiens) 		4 / 7 ILE A 634
GLU A 707
GLY A 701
GLY A 700
 None
 0.87A 5a06F-3hr0A:
undetectable		 5a06F-3hr0A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_B_REAB503_1
(RETINOIC ACID
RECEPTOR BETA)		 3hr0 COG4
(Homo
sapiens) 		5 / 12 LEU A 711
LEU A 708
PHE A 696
PHE A 627
VAL A 683
 None
 1.32A 5uanB-3hr0A:
undetectable		 5uanB-3hr0A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3hr0 COG4
(Homo
sapiens) 		3 / 3 PHE A 600
ASP A 602
LEU A 675
 None
 0.72A 5uhbC-3hr0A:
undetectable		 5uhbC-3hr0A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3hr0 COG4
(Homo
sapiens) 		3 / 3 PHE A 600
ASP A 602
LEU A 675
 None
 0.65A 5uhcC-3hr0A:
undetectable		 5uhcC-3hr0A:
12.50