SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hr8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ4_A_CAMA502_0
(CYTOCHROME P450-CAM)		 3hr8 PROTEIN RECA
(Thermotoga
maritima) 		4 / 6 TYR A  58
LEU A  77
VAL A 246
ASP A  50
 None
 1.09A 1dz4A-3hr8A:
undetectable		 1dz4A-3hr8A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ4_B_CAMB502_0
(CYTOCHROME P450-CAM)		 3hr8 PROTEIN RECA
(Thermotoga
maritima) 		4 / 6 TYR A  58
LEU A  77
VAL A 246
ASP A  50
 None
 1.14A 1dz4B-3hr8A:
undetectable		 1dz4B-3hr8A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3hr8 PROTEIN RECA
(Thermotoga
maritima) 		5 / 10 GLY A  57
VAL A  55
GLY A  54
THR A  44
VAL A  41
 None
 1.30A 1pwyE-3hr8A:
undetectable		 1pwyE-3hr8A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3hr8 PROTEIN RECA
(Thermotoga
maritima) 		5 / 10 GLY A  57
VAL A  55
GLY A  54
THR A  44
VAL A  41
 None
 1.31A 1v3qE-3hr8A:
undetectable		 1v3qE-3hr8A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_A_REAA502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3hr8 PROTEIN RECA
(Thermotoga
maritima) 		5 / 12 ALA A  85
GLN A  86
LEU A 142
ALA A  92
ILE A  49
 None
 0.95A 2aclA-3hr8A:
undetectable
2aclE-3hr8A:
undetectable		 2aclA-3hr8A:
22.04
2aclE-3hr8A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_J_ACTJ1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 3hr8 PROTEIN RECA
(Thermotoga
maritima) 		4 / 8 GLU A 235
ILE A 240
LYS A 268
ILE A 265
 None
 0.91A 2j9dJ-3hr8A:
undetectable
2j9dK-3hr8A:
undetectable
2j9dL-3hr8A:
undetectable		 2j9dJ-3hr8A:
17.70
2j9dK-3hr8A:
17.70
2j9dL-3hr8A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN0_A_TDZA501_1
(CYTOCHROME P450 2C8)		 3hr8 PROTEIN RECA
(Thermotoga
maritima) 		5 / 12 ILE A  63
LEU A 177
VAL A 184
VAL A 131
GLU A 129
 None
 1.16A 2vn0A-3hr8A:
undetectable		 2vn0A-3hr8A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 3hr8 PROTEIN RECA
(Thermotoga
maritima) 		5 / 12 THR A  53
ILE A  49
GLY A  56
LEU A  47
VAL A  39
 None
 0.97A 2yvlB-3hr8A:
3.2		 2yvlB-3hr8A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZAW_A_CAMA422_0
(CYTOCHROME P450-CAM)		 3hr8 PROTEIN RECA
(Thermotoga
maritima) 		4 / 6 TYR A  58
LEU A  77
VAL A 246
ASP A  50
 None
 1.17A 2zawA-3hr8A:
undetectable		 2zawA-3hr8A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCM_X_SAMX5452_0
(UNCHARACTERIZED
PROTEIN TM_1570)		 3hr8 PROTEIN RECA
(Thermotoga
maritima) 		5 / 11 ALA A 189
GLY A 138
ILE A  42
LEU A 142
VAL A  91
 None
 0.96A 3dcmX-3hr8A:
undetectable		 3dcmX-3hr8A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_1
(CYTOCHROME P450 2R1)		 3hr8 PROTEIN RECA
(Thermotoga
maritima) 		4 / 5 ALA A  48
LEU A 336
GLY A  56
THR A 222
 None
 0.96A 3dl9A-3hr8A:
undetectable		 3dl9A-3hr8A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 3hr8 PROTEIN RECA
(Thermotoga
maritima) 		4 / 6 GLY A  54
THR A  44
GLU A  33
GLU A 283
 None
 0.98A 3fpjA-3hr8A:
undetectable		 3fpjA-3hr8A:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA304_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 3hr8 PROTEIN RECA
(Thermotoga
maritima) 		4 / 4 GLN A  37
PRO A  38
VAL A  39
GLU A  40
 None
 1.24A 3huoA-3hr8A:
undetectable		 3huoA-3hr8A:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_C_AG2C1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 3hr8 PROTEIN RECA
(Thermotoga
maritima) 		4 / 8 LYS A  74
LEU A  79
ASP A 146
ASP A  96
 None
 1.13A 3n2oC-3hr8A:
undetectable
3n2oD-3hr8A:
undetectable		 3n2oC-3hr8A:
21.95
3n2oD-3hr8A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_B_QELB1_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 3hr8 PROTEIN RECA
(Thermotoga
maritima) 		5 / 11 THR A  75
ALA A  81
ILE A  82
PHE A  94
THR A 222
 None
 1.45A 3qelA-3hr8A:
undetectable
3qelB-3hr8A:
3.4		 3qelA-3hr8A:
22.06
3qelB-3hr8A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRH_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 3hr8 PROTEIN RECA
(Thermotoga
maritima) 		4 / 6 TYR A  58
LEU A  77
VAL A 246
ASP A  50
 None
 1.08A 3wrhE-3hr8A:
undetectable		 3wrhE-3hr8A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRJ_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 3hr8 PROTEIN RECA
(Thermotoga
maritima) 		4 / 6 TYR A  58
LEU A  77
VAL A 246
ASP A  50
 None
 1.10A 3wrjE-3hr8A:
undetectable		 3wrjE-3hr8A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3hr8 PROTEIN RECA
(Thermotoga
maritima) 		4 / 7 ASN A 195
GLU A 209
GLU A 226
GLU A  65
 None
 1.02A 4mj8C-3hr8A:
undetectable		 4mj8C-3hr8A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_I_SPMI202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3hr8 PROTEIN RECA
(Thermotoga
maritima) 		4 / 7 ASN A 195
GLU A 209
GLU A 226
GLU A  65
 None
 0.96A 4r87I-3hr8A:
undetectable		 4r87I-3hr8A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_A_HFGA802_1
(PROLINE--TRNA LIGASE)		 3hr8 PROTEIN RECA
(Thermotoga
maritima) 		4 / 4 THR A 262
GLU A 275
THR A  76
HIS A  80
 None
 1.47A 4ydqA-3hr8A:
0.9		 4ydqA-3hr8A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH614_0
(NADH DEHYDROGENASE,
PUTATIVE)		 3hr8 PROTEIN RECA
(Thermotoga
maritima) 		4 / 6 ILE A  63
VAL A 135
VAL A 191
SER A 187
 None
 0.99A 5jwaH-3hr8A:
undetectable		 5jwaH-3hr8A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_1_PQN1842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 3hr8 PROTEIN RECA
(Thermotoga
maritima) 		5 / 10 ALA A 221
LEU A 217
GLY A 214
ILE A  82
LEU A 116
 None
 1.24A 5oy01-3hr8A:
undetectable
5oy07-3hr8A:
undetectable		 5oy01-3hr8A:
13.64
5oy07-3hr8A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_1
(CYTOCHROME P450 3A5)		 3hr8 PROTEIN RECA
(Thermotoga
maritima) 		5 / 12 LEU A 128
PHE A 193
ILE A  95
ALA A  93
GLY A  61
 None
 1.04A 5veuA-3hr8A:
undetectable		 5veuA-3hr8A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_G_CHDG401_0
(BILE SALT HYDROLASE)		 3hr8 PROTEIN RECA
(Thermotoga
maritima) 		5 / 10 LEU A 128
ILE A  63
PHE A 219
LEU A 215
GLU A 125
 None
 1.22A 5y7pG-3hr8A:
undetectable		 5y7pG-3hr8A:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3hr8 PROTEIN RECA
(Thermotoga
maritima) 		5 / 12 ALA A  85
GLN A  86
LEU A 142
ALA A  92
ILE A  49
 None
 0.98A 6a5yD-3hr8A:
undetectable		 6a5yD-3hr8A:
12.93