SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hra'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_D_SAMD200_0
(METHIONINE REPRESSOR)		 3hra ANKYRIN REPEAT
FAMILY PROTEIN
(Enterococcus
faecalis) 		5 / 12 HIS A 118
ALA A 113
GLY A  83
GLU A 131
ALA A 114
 None
 1.09A 1mjqC-3hraA:
undetectable
1mjqD-3hraA:
undetectable		 1mjqC-3hraA:
17.95
1mjqD-3hraA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_J_SAMJ200_0
(METHIONINE REPRESSOR)		 3hra ANKYRIN REPEAT
FAMILY PROTEIN
(Enterococcus
faecalis) 		5 / 12 HIS A 118
ALA A 113
GLY A  83
GLU A 131
ALA A 114
 None
 1.08A 1mjqI-3hraA:
undetectable
1mjqJ-3hraA:
undetectable		 1mjqI-3hraA:
17.95
1mjqJ-3hraA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W13_A_ACTA1208_0
(ZINC
METALLOPROTEINASE
BAP1)		 3hra ANKYRIN REPEAT
FAMILY PROTEIN
(Enterococcus
faecalis) 		4 / 4 THR A  85
ARG A  84
GLU A  86
ASN A  50
 None
 0.93A 2w13A-3hraA:
0.0		 2w13A-3hraA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_A_BEZA264_0
(ECHA1_1)		 3hra ANKYRIN REPEAT
FAMILY PROTEIN
(Enterococcus
faecalis) 		4 / 8 ALA A  55
ILE A  59
LEU A  43
ALA A  79
 None
 0.70A 3r9tA-3hraA:
undetectable		 3r9tA-3hraA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_SAMA301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 3hra ANKYRIN REPEAT
FAMILY PROTEIN
(Enterococcus
faecalis) 		5 / 12 GLY A 107
GLY A 106
SER A  72
ALA A  81
GLN A  82
 CL  A 202 (-3.5A)
None
None
None
None
 0.91A 4htfA-3hraA:
undetectable		 4htfA-3hraA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_B_SAMB301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 3hra ANKYRIN REPEAT
FAMILY PROTEIN
(Enterococcus
faecalis) 		5 / 12 GLY A 107
GLY A 106
SER A  72
ALA A  81
GLN A  82
 CL  A 202 (-3.5A)
None
None
None
None
 0.94A 4htfB-3hraA:
undetectable		 4htfB-3hraA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 3hra ANKYRIN REPEAT
FAMILY PROTEIN
(Enterococcus
faecalis) 		5 / 12 MET A  91
ILE A  65
ALA A  79
THR A  18
VAL A  21
 None
 1.32A 4qynA-3hraA:
undetectable		 4qynA-3hraA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_A_4LEA401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3hra ANKYRIN REPEAT
FAMILY PROTEIN
(Enterococcus
faecalis) 		5 / 8 ALA A  46
ALA A  57
LEU A  25
LEU A   9
ALA A  13
 None
 1.09A 4z90A-3hraA:
undetectable
4z90B-3hraA:
undetectable
4z90C-3hraA:
undetectable
4z90D-3hraA:
undetectable
4z90E-3hraA:
undetectable		 4z90A-3hraA:
21.05
4z90B-3hraA:
21.05
4z90C-3hraA:
21.05
4z90D-3hraA:
21.05
4z90E-3hraA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF402_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3hra ANKYRIN REPEAT
FAMILY PROTEIN
(Enterococcus
faecalis) 		4 / 7 LEU A   9
ALA A  13
ALA A  46
LEU A  25
 None
 0.65A 4z90F-3hraA:
undetectable
4z90G-3hraA:
undetectable
4z90H-3hraA:
undetectable
4z90J-3hraA:
undetectable		 4z90F-3hraA:
21.05
4z90G-3hraA:
21.05
4z90H-3hraA:
21.05
4z90J-3hraA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF402_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3hra ANKYRIN REPEAT
FAMILY PROTEIN
(Enterococcus
faecalis) 		5 / 7 LEU A  25
LEU A   9
ALA A  13
ALA A  46
ALA A  57
 None
 1.12A 4z90F-3hraA:
undetectable
4z90G-3hraA:
undetectable
4z90H-3hraA:
undetectable
4z90J-3hraA:
undetectable		 4z90F-3hraA:
21.05
4z90G-3hraA:
21.05
4z90H-3hraA:
21.05
4z90J-3hraA:
21.05