SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hri'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_A_HISA450_0
(HISTIDYL-TRNA
SYNTHETASE)		 3hri HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
brucei) 		5 / 10 GLU A 125
THR A 127
GLN A 169
TYR A 317
GLY A 338
 None
 0.98A 1httA-3hriA:
31.2		 1httA-3hriA:
27.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_A_HISA450_0
(HISTIDYL-TRNA
SYNTHETASE)		 3hri HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
brucei) 		5 / 10 GLU A 125
THR A 127
GLN A 169
TYR A 317
GLY A 358
 None
 1.42A 1httA-3hriA:
31.2		 1httA-3hriA:
27.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_A_HISA450_0
(HISTIDYL-TRNA
SYNTHETASE)		 3hri HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
brucei) 		5 / 10 THR A 127
GLN A 169
TYR A 317
TYR A 318
GLY A 338
 None
 0.86A 1httA-3hriA:
31.2		 1httA-3hriA:
27.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)		 3hri HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
brucei) 		7 / 12 GLU A 125
THR A 127
GLN A 169
TYR A 317
GLY A 338
TYR A 341
GLY A 358
 None
 1.00A 1httB-3hriA:
31.0		 1httB-3hriA:
27.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)		 3hri HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
brucei) 		7 / 12 THR A 127
GLN A 169
TYR A 317
TYR A 318
GLY A 338
TYR A 341
GLY A 358
 None
 0.87A 1httB-3hriA:
31.0		 1httB-3hriA:
27.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 3hri HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
brucei) 		6 / 12 GLU A 125
THR A 127
GLN A 169
TYR A 317
GLY A 338
GLY A 358
 None
 0.94A 1httC-3hriA:
31.4		 1httC-3hriA:
27.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 3hri HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
brucei) 		6 / 12 GLU A 125
THR A 127
GLN A 169
TYR A 317
TYR A 341
GLY A 358
 None
 1.05A 1httC-3hriA:
31.4		 1httC-3hriA:
27.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 3hri HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
brucei) 		6 / 12 THR A 127
GLN A 169
TYR A 317
TYR A 318
GLY A 338
GLY A 358
 None
 0.86A 1httC-3hriA:
31.4		 1httC-3hriA:
27.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 3hri HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
brucei) 		6 / 12 THR A 127
GLN A 169
TYR A 317
TYR A 318
TYR A 341
GLY A 358
 None
 1.06A 1httC-3hriA:
31.4		 1httC-3hriA:
27.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		 3hri HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
brucei) 		6 / 12 GLU A 125
THR A 127
GLN A 169
TYR A 317
GLY A 338
GLY A 358
 None
 0.95A 1httD-3hriA:
31.2		 1httD-3hriA:
27.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		 3hri HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
brucei) 		6 / 12 THR A 127
GLN A 169
TYR A 317
TYR A 318
GLY A 338
GLY A 358
 None
 0.84A 1httD-3hriA:
31.2		 1httD-3hriA:
27.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T87_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 3hri HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
brucei) 		4 / 7 PHE A 361
VAL A 204
VAL A 365
ILE A 366
 None
 0.99A 1t87B-3hriA:
undetectable		 1t87B-3hriA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_T_NCTT1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3hri HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
brucei) 		4 / 8 TRP A 147
LEU A 345
TYR A  86
THR A 127
 None
 1.23A 1uw6P-3hriA:
undetectable
1uw6T-3hriA:
undetectable		 1uw6P-3hriA:
18.20
1uw6T-3hriA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_B_VD3B700_1
(CYTOCHROME P450 2R1)		 3hri HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
brucei) 		6 / 12 PHE A 323
ALA A 334
ALA A 190
VAL A 187
GLY A 358
VAL A 233
 None
 1.24A 3c6gB-3hriA:
undetectable		 3c6gB-3hriA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		 3hri HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
brucei) 		5 / 12 PHE A 323
ALA A 334
ALA A 190
VAL A 187
VAL A 233
 None
 0.97A 3czhB-3hriA:
undetectable		 3czhB-3hriA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D41_A_FCNA4001_1
(FOMA PROTEIN)		 3hri HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
brucei) 		4 / 8 GLY A 337
GLY A 338
GLY A 339
ILE A 321
 None
 0.67A 3d41A-3hriA:
undetectable		 3d41A-3hriA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM201_1
(PROTEIN S100-A4)		 3hri HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
brucei) 		4 / 7 GLY A 362
PHE A 359
GLY A 337
PHE A 323
 None
 0.89A 3ko0M-3hriA:
1.5
3ko0P-3hriA:
1.6		 3ko0M-3hriA:
13.23
3ko0P-3hriA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5T_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 3hri HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
brucei) 		4 / 7 SER A 149
TRP A 170
PHE A  83
GLU A  85
 None
 1.40A 3n5tA-3hriA:
undetectable
3n5tB-3hriA:
undetectable		 3n5tA-3hriA:
22.10
3n5tB-3hriA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 3hri HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
brucei) 		3 / 3 PHE A 301
SER A 201
GLN A 195
 None
 0.96A 3smtA-3hriA:
undetectable		 3smtA-3hriA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 3hri HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
brucei) 		4 / 6 PHE A 425
ALA A 436
GLY A 468
LEU A 438
 None
 0.94A 4dubA-3hriA:
undetectable		 4dubA-3hriA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_B_IMNB201_1
(TRANSTHYRETIN)		 3hri HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
brucei) 		4 / 6 ALA A 353
LEU A 345
SER A 350
THR A 352
 None
 1.02A 4ikiB-3hriA:
undetectable		 4ikiB-3hriA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_A_SUZA201_1
(TRANSTHYRETIN)		 3hri HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
brucei) 		4 / 7 ALA A 353
LEU A 345
SER A 350
THR A 352
 None
 0.96A 4ikjA-3hriA:
undetectable
4ikjB-3hriA:
undetectable		 4ikjA-3hriA:
14.45
4ikjB-3hriA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_B_SUZB201_1
(TRANSTHYRETIN)		 3hri HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
brucei) 		4 / 7 ALA A 353
LEU A 345
SER A 350
THR A 352
 None
 1.05A 4ikkA-3hriA:
undetectable
4ikkB-3hriA:
undetectable		 4ikkA-3hriA:
14.45
4ikkB-3hriA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3hri HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
brucei) 		3 / 3 LEU A 376
PRO A 377
ARG A  57
 None
 0.48A 4klrB-3hriA:
undetectable		 4klrB-3hriA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_1
(PROLINE--TRNA LIGASE)		 3hri HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
brucei) 		3 / 3 GLU A 288
THR A 216
HIS A 283
 None
 0.83A 4q15A-3hriA:
8.9		 4q15A-3hriA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_1
(PROLINE--TRNA LIGASE)		 3hri HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
brucei) 		3 / 3 GLU A 288
THR A 216
HIS A 283
 None
 0.81A 4q15B-3hriA:
17.4		 4q15B-3hriA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3hri HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
brucei) 		5 / 7 ALA A 229
ASP A 342
ARG A 340
GLY A 339
GLU A 183
 None
 1.38A 5bs8A-3hriA:
undetectable
5bs8C-3hriA:
undetectable
5bs8D-3hriA:
undetectable		 5bs8A-3hriA:
21.92
5bs8C-3hriA:
21.92
5bs8D-3hriA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 3hri HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
brucei) 		5 / 7 ALA A 229
ASP A 342
ARG A 340
GLY A 339
GLU A 183
 None
 1.36A 5bs8A-3hriA:
1.4
5bs8B-3hriA:
undetectable
5bs8C-3hriA:
undetectable		 5bs8A-3hriA:
21.92
5bs8B-3hriA:
22.85
5bs8C-3hriA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3hri HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
brucei) 		4 / 7 ALA A 229
ASP A 342
GLY A 339
GLU A 183
 None
 0.93A 5btgA-3hriA:
1.4
5btgC-3hriA:
1.4
5btgD-3hriA:
undetectable		 5btgA-3hriA:
21.92
5btgC-3hriA:
21.92
5btgD-3hriA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 3hri HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
brucei) 		7 / 12 GLU A 125
THR A 127
GLN A 169
TYR A 317
GLY A 338
TYR A 341
GLY A 358
 None
 1.06A 5e3iA-3hriA:
31.1		 5e3iA-3hriA:
28.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 3hri HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
brucei) 		7 / 12 THR A 127
GLN A 169
TYR A 317
TYR A 318
GLY A 338
TYR A 341
GLY A 358
 None
 0.94A 5e3iA-3hriA:
31.1		 5e3iA-3hriA:
28.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_B_HISB502_0
(HISTIDINE--TRNA
LIGASE)		 3hri HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
brucei) 		7 / 11 GLU A 125
THR A 127
GLN A 169
TYR A 317
GLY A 338
TYR A 341
GLY A 358
 None
 1.06A 5e3iB-3hriA:
31.7		 5e3iB-3hriA:
28.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_B_HISB502_0
(HISTIDINE--TRNA
LIGASE)		 3hri HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
brucei) 		7 / 11 THR A 127
GLN A 169
TYR A 317
TYR A 318
GLY A 338
TYR A 341
GLY A 358
 None
 0.95A 5e3iB-3hriA:
31.7		 5e3iB-3hriA:
28.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_A_SAMA4001_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)		 3hri HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
brucei) 		5 / 12 GLY A 360
GLY A 337
GLY A 339
GLU A 324
ASP A 363
 None
 0.95A 5ehiA-3hriA:
undetectable		 5ehiA-3hriA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_C_SAMC4000_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)		 3hri HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
brucei) 		5 / 12 GLY A 360
GLY A 337
GLY A 339
GLU A 324
ASP A 363
 None
 0.96A 5ehiC-3hriA:
undetectable		 5ehiC-3hriA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 3hri HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
brucei) 		5 / 12 GLY A 360
GLY A 337
GLY A 339
GLU A 324
ASP A 363
 None
 1.00A 5eiwA-3hriA:
undetectable		 5eiwA-3hriA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_B_AC2B301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3hri HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
brucei) 		5 / 10 GLY A 432
ALA A 412
VAL A 383
ASP A 429
ILE A 431
 None
 1.10A 5i3cB-3hriA:
undetectable		 5i3cB-3hriA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 3hri HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
brucei) 		3 / 3 ARG A 123
PRO A 151
ASN A 171
 None
 1.07A 5jwaA-3hriA:
undetectable
5jwaH-3hriA:
undetectable		 5jwaA-3hriA:
22.11
5jwaH-3hriA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO8_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3hri HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
brucei) 		4 / 6 SER A 149
TRP A 170
PHE A  83
GLU A  85
 None
 1.47A 5uo8A-3hriA:
undetectable
5uo8B-3hriA:
undetectable		 5uo8A-3hriA:
22.48
5uo8B-3hriA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZSF_B_6T0B913_0
(TOLL-LIKE RECEPTOR 7)		 3hri HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
brucei) 		5 / 9 VAL A 231
PHE A 228
LYS A 226
LEU A 255
ILE A 263
 None
 1.46A 5zsfA-3hriA:
0.0
5zsfB-3hriA:
0.0		 5zsfA-3hriA:
11.43
5zsfB-3hriA:
11.43