SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hrp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_1
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 3hrp UNCHARACTERIZED
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 5 VAL A 381
SER A 379
ASP A 354
GLN A 125
 None
None
MPD  A   1 (-3.3A)
MPD  A   1 (-4.6A)
 1.47A 1n2xB-3hrpA:
undetectable		 1n2xB-3hrpA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_B_SAMB2401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 3hrp UNCHARACTERIZED
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 12 LEU A 254
GLY A 235
ILE A 209
THR A 229
PRO A 228
 None
 1.06A 1p91B-3hrpA:
undetectable		 1p91B-3hrpA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3hrp UNCHARACTERIZED
PROTEIN
(Bacteroides
thetaiotaomicron) 		3 / 3 SER A 133
GLY A 134
ARG A 176
 None
 0.58A 1t9wA-3hrpA:
undetectable		 1t9wA-3hrpA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 3hrp UNCHARACTERIZED
PROTEIN
(Bacteroides
thetaiotaomicron) 		3 / 3 ASP A 145
ASN A 183
THR A 164
 None
 0.75A 2q63B-3hrpA:
undetectable		 2q63B-3hrpA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 3hrp UNCHARACTERIZED
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 6 TYR A 414
GLY A 355
THR A 350
GLU A 249
 None
 1.00A 3fpjA-3hrpA:
undetectable		 3fpjA-3hrpA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 3hrp UNCHARACTERIZED
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 12 ILE A 157
GLY A 156
ALA A 244
ALA A 419
ASN A 347
 None
 0.83A 3jb3A-3hrpA:
undetectable		 3jb3A-3hrpA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP5_B_KANB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3hrp UNCHARACTERIZED
PROTEIN
(Bacteroides
thetaiotaomicron) 		3 / 3 ALA A 419
ARG A 170
LYS A 193
 None
 0.67A 3kp5B-3hrpA:
undetectable		 3kp5B-3hrpA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QJ7_A_SPMA264_1
(THYMIDYLATE SYNTHASE)		 3hrp UNCHARACTERIZED
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 8 ARG A  98
ASP A 372
ASP A 354
TYR A 358
 MPD  A   1 (-4.5A)
EDO  A   8 (-2.6A)
MPD  A   1 (-3.3A)
None
 0.98A 3qj7A-3hrpA:
undetectable
3qj7D-3hrpA:
undetectable		 3qj7A-3hrpA:
22.56
3qj7D-3hrpA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 3hrp UNCHARACTERIZED
PROTEIN
(Bacteroides
thetaiotaomicron) 		3 / 3 TYR A 153
MET A 154
ILE A 132
 None
 0.73A 4c8bB-3hrpA:
undetectable		 4c8bB-3hrpA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_1
(ADENOSINE KINASE)		 3hrp UNCHARACTERIZED
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 12 LEU A 247
GLY A 243
LEU A 254
GLY A 348
ASP A 405
 None
 0.99A 4dc3A-3hrpA:
undetectable		 4dc3A-3hrpA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_H_SAMH501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 3hrp UNCHARACTERIZED
PROTEIN
(Bacteroides
thetaiotaomicron) 		6 / 10 PRO A 403
GLY A 365
VAL A 360
LEU A 368
THR A 380
ALA A 382
 None
 1.43A 5o96G-3hrpA:
undetectable
5o96H-3hrpA:
undetectable		 5o96G-3hrpA:
20.05
5o96H-3hrpA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))		 3hrp UNCHARACTERIZED
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 12 GLY A 326
PHE A 343
VAL A 257
PRO A 291
ILE A 359
 None
 1.15A 5tuiB-3hrpA:
undetectable		 5tuiB-3hrpA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DHB_A_BEZA202_0
(HEPATITIS A VIRUS
CELLULAR RECEPTOR 2)		 3hrp UNCHARACTERIZED
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 6 PHE A 297
ILE A 373
ASN A 356
ASP A 352
 None
None
EDO  A   8 ( 4.3A)
MPD  A   1 (-3.4A)
 1.24A 6dhbA-3hrpA:
undetectable		 6dhbA-3hrpA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_2
(TUBULIN BETA CHAIN)		 3hrp UNCHARACTERIZED
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 5 LEU A 254
THR A 216
PRO A 173
ARG A 176
 None
EDO  A  15 (-3.2A)
None
None
 1.03A 6ew0F-3hrpA:
undetectable		 6ew0F-3hrpA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_2
(TUBULIN BETA CHAIN)		 3hrp UNCHARACTERIZED
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 6 LEU A 254
THR A 216
PRO A 173
ARG A 176
 None
EDO  A  15 (-3.2A)
None
None
 1.03A 6ew0G-3hrpA:
undetectable		 6ew0G-3hrpA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBF_A_ACTA507_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 3hrp UNCHARACTERIZED
PROTEIN
(Bacteroides
thetaiotaomicron) 		3 / 3 LYS A 150
SER A 135
SER A 137
 None
 0.90A 6gbfA-3hrpA:
undetectable		 6gbfA-3hrpA:
23.08