SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hrw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 3hrw HEMOGLOBIN SUBUNIT
BETA-1
(Mus
musculus) 		4 / 7 PHE B  42
PHE B  45
VAL B  67
HIS B  92
 HEM  B 200 (-3.8A)
HEM  B 200 (-4.2A)
HEM  B 200 (-3.6A)
HEM  B 200 (-2.9A)
 0.72A 1lh6A-3hrwB:
13.6		 1lh6A-3hrwB:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_A_EAAA222_1
(GLUTATHIONE
S-TRANSFERASE P)		 3hrw HEMOGLOBIN SUBUNIT
BETA-1
(Mus
musculus) 		5 / 10 VAL B 134
VAL B  67
ILE B 112
ASN B 108
GLY B 107
 None
HEM  B 200 (-3.6A)
None
None
None
 1.30A 3km6A-3hrwB:
undetectable		 3km6A-3hrwB:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3hrw HEMOGLOBIN SUBUNIT
BETA-1
(Mus
musculus) 		4 / 7 SER B  20
ASN B  72
ILE B  68
ASN B  19
 None
 1.15A 4d33B-3hrwB:
undetectable		 4d33B-3hrwB:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3hrw HEMOGLOBIN SUBUNIT
BETA-1
(Mus
musculus) 		4 / 7 ILE B 110
GLY B  64
LEU B  32
MET B  55
 None
 0.88A 4zdzA-3hrwB:
undetectable		 4zdzA-3hrwB:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESJ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3hrw HEMOGLOBIN SUBUNIT
BETA-1
(Mus
musculus) 		4 / 8 ILE B 110
GLY B  64
LEU B  32
MET B  55
 None
 0.86A 5esjA-3hrwB:
undetectable		 5esjA-3hrwB:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH614_0
(NADH DEHYDROGENASE,
PUTATIVE)		 3hrw HEMOGLOBIN SUBUNIT
BETA-1
(Mus
musculus) 		4 / 6 ILE B  68
VAL B  18
VAL B  23
TRP B  15
 None
 0.94A 5jwaH-3hrwB:
undetectable		 5jwaH-3hrwB:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BC9_A_ETSA302_2
(CARBONIC ANHYDRASE 2)		 3hrw HEMOGLOBIN SUBUNIT
BETA-1
(Mus
musculus) 		4 / 5 GLU B  26
HIS B 117
LEU B  14
VAL B  18
 None
 0.97A 6bc9A-3hrwB:
undetectable		 6bc9A-3hrwB:
21.64