SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hs3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA355_1
(PROTEIN (ADENOSINE
KINASE))		 3hs3 RIBOSE OPERON
REPRESSOR
(Lactobacillus
acidophilus) 		5 / 12 GLY A  80
VAL A  84
ILE A  64
HIS A 291
ILE A 121
 None
 0.88A 1bx4A-3hs3A:
3.7		 1bx4A-3hs3A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_F_TFPF211_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3hs3 RIBOSE OPERON
REPRESSOR
(Lactobacillus
acidophilus) 		4 / 7 LEU A 133
PHE A 131
PHE A 125
SER A 142
 None
 1.02A 1wrlE-3hs3A:
undetectable
1wrlF-3hs3A:
undetectable		 1wrlE-3hs3A:
16.10
1wrlF-3hs3A:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YNN_C_RFPC1120_1
(DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN)		 3hs3 RIBOSE OPERON
REPRESSOR
(Lactobacillus
acidophilus) 		5 / 12 ASP A 279
ARG A 315
SER A 317
LEU A 259
ILE A 275
 None
 1.26A 1ynnC-3hs3A:
undetectable		 1ynnC-3hs3A:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 3hs3 RIBOSE OPERON
REPRESSOR
(Lactobacillus
acidophilus) 		5 / 11 HIS A 291
LEU A 294
ILE A  62
VAL A 138
ILE A 152
 None
 1.18A 2uxoB-3hs3A:
undetectable		 2uxoB-3hs3A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 3hs3 RIBOSE OPERON
REPRESSOR
(Lactobacillus
acidophilus) 		4 / 4 ASN A 235
SER A 182
LEU A 183
THR A 233
 None
 1.37A 4an2A-3hs3A:
undetectable		 4an2A-3hs3A:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMU_C_RFPC1401_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3hs3 RIBOSE OPERON
REPRESSOR
(Lactobacillus
acidophilus) 		5 / 12 ASP A 279
ARG A 315
SER A 317
LEU A 259
ILE A 275
 None
 1.30A 4kmuC-3hs3A:
undetectable		 4kmuC-3hs3A:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYS_B_VIBB501_1
(THIAMINE
PYRIDINYLASE I)		 3hs3 RIBOSE OPERON
REPRESSOR
(Lactobacillus
acidophilus) 		5 / 11 ASP A 263
ILE A 275
TYR A 262
ASP A 236
LEU A 259
 None
 1.26A 4kysB-3hs3A:
1.7		 4kysB-3hs3A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YOA_A_017A100_1
(HIV-1 PROTEASE)		 3hs3 RIBOSE OPERON
REPRESSOR
(Lactobacillus
acidophilus) 		4 / 6 ASN A 235
THR A 209
PRO A 210
VAL A 234
 None
 1.13A 4yoaA-3hs3A:
undetectable		 4yoaA-3hs3A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_A_ADNA401_1
(ADENOSINE KINASE)		 3hs3 RIBOSE OPERON
REPRESSOR
(Lactobacillus
acidophilus) 		6 / 12 GLY A  80
VAL A  84
ILE A  64
HIS A 291
ALA A 289
ILE A 121
 None
 1.12A 5kb6A-3hs3A:
3.6		 5kb6A-3hs3A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_B_ADNB401_1
(ADENOSINE KINASE)		 3hs3 RIBOSE OPERON
REPRESSOR
(Lactobacillus
acidophilus) 		6 / 12 GLY A  80
VAL A  84
ILE A  64
HIS A 291
ALA A 289
ILE A 121
 None
 1.12A 5kb6B-3hs3A:
3.3		 5kb6B-3hs3A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_A_BEZA301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 3hs3 RIBOSE OPERON
REPRESSOR
(Lactobacillus
acidophilus) 		4 / 7 ILE A 121
LEU A 293
MET A 297
LEU A 294
 None
 0.93A 5u4sA-3hs3A:
2.3		 5u4sA-3hs3A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAC_C_RFPC3001_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3hs3 RIBOSE OPERON
REPRESSOR
(Lactobacillus
acidophilus) 		5 / 12 ASP A 279
ARG A 315
SER A 317
LEU A 259
ILE A 275
 None
 1.31A 5uacC-3hs3A:
0.0		 5uacC-3hs3A:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA504_1
(CYTOCHROME P450 2C9)		 3hs3 RIBOSE OPERON
REPRESSOR
(Lactobacillus
acidophilus) 		4 / 8 ILE A 285
ASN A  71
PRO A 184
THR A 185
 None
 1.09A 5x23A-3hs3A:
undetectable		 5x23A-3hs3A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA503_1
(CYTOCHROME P450 2C9)		 3hs3 RIBOSE OPERON
REPRESSOR
(Lactobacillus
acidophilus) 		5 / 12 ILE A 285
PHE A  73
ASN A  71
PRO A 184
THR A 185
 None
 1.28A 5xxiA-3hs3A:
undetectable		 5xxiA-3hs3A:
20.04