SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hs8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ZQ9_B_SAMB4001_0 (PROBABLE DIMETHYLADENOSINE TRANSFERASE)	3hs8	ADAPTOR PROTEIN COMPLEX AP-2, ALPHA 2 SUBUNIT (Mus musculus)	5 / 12	GLY A 725 VAL A 787 LEU A 818 PRO A 819 ILE A 820	None	0.89A	1zq9B-3hs8A: undetectable	1zq9B-3hs8A: 20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2C12_C_SPMC1434_1 (NITROALKANE OXIDASE)	3hs8	ADAPTOR PROTEIN COMPLEX AP-2, ALPHA 2 SUBUNIT (Mus musculus)	5 / 12	LEU A 756 LEU A 726 MET A 737 LEU A 801 VAL A 816	None	1.20A	2c12C-3hs8A: undetectable	2c12C-3hs8A: 19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NXE_A_SAMA302_1 (RIBOSOMAL PROTEIN L11 METHYLTRANSFERASE)	3hs8	ADAPTOR PROTEIN COMPLEX AP-2, ALPHA 2 SUBUNIT (Mus musculus)	3 / 3	THR A 796 ASP A 924 SER A 922	None	0.83A	2nxeA-3hs8A: undetectable	2nxeA-3hs8A: 20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NXE_B_SAMB303_1 (RIBOSOMAL PROTEIN L11 METHYLTRANSFERASE)	3hs8	ADAPTOR PROTEIN COMPLEX AP-2, ALPHA 2 SUBUNIT (Mus musculus)	3 / 3	THR A 796 ASP A 924 SER A 922	None	0.83A	2nxeB-3hs8A: undetectable	2nxeB-3hs8A: 20.20

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1ZQ9_B_SAMB4001_0","PROBABLE DIMETHYLADENOSINE TRANSFERASE","3hs8","ADAPTOR PROTEIN COMPLEX AP-2, ALPHA 2 SUBUNIT","Mus musculus",5,"GLY A 725;VAL A 787;LEU A 818;PRO A 819;ILE A 820","None","0.89A","1zq9B-3hs8A:undetectable","1zq9B-3hs8A:20.62"],["2C12_C_SPMC1434_1","NITROALKANE OXIDASE","3hs8","ADAPTOR PROTEIN COMPLEX AP-2, ALPHA 2 SUBUNIT","Mus musculus",5,"LEU A 756;LEU A 726;MET A 737;LEU A 801;VAL A 816","None","1.20A","2c12C-3hs8A:undetectable","2c12C-3hs8A:19.69"],["2NXE_A_SAMA302_1","RIBOSOMAL PROTEIN L11 METHYLTRANSFERASE","3hs8","ADAPTOR PROTEIN COMPLEX AP-2, ALPHA 2 SUBUNIT","Mus musculus",3,"THR A 796;ASP A 924;SER A 922","None","0.83A","2nxeA-3hs8A:undetectable","2nxeA-3hs8A:20.20"],["2NXE_B_SAMB303_1","RIBOSOMAL PROTEIN L11 METHYLTRANSFERASE","3hs8","ADAPTOR PROTEIN COMPLEX AP-2, ALPHA 2 SUBUNIT","Mus musculus",3,"THR A 796;ASP A 924;SER A 922","None","0.83A","2nxeB-3hs8A:undetectable","2nxeB-3hs8A:20.20"]]