SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hsa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EPB_A_9CRA165_1 (EPIDIDYMAL RETINOIC ACID-BINDING PROTEIN)	3hsa	PLECKSTRIN HOMOLOGY DOMAIN (Shewanella amazonensis)	5 / 12	ILE A 95 LEU A 53 ALA A 123 ILE A 119 ILE A 115	None MLY A 104 ( 4.8A) None None None	0.97A	1epbA-3hsaA: undetectable	1epbA-3hsaA: 22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LCV_B_SAMB301_0 (SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM)	3hsa	PLECKSTRIN HOMOLOGY DOMAIN (Shewanella amazonensis)	5 / 12	THR A 118 ALA A 36 ASP A 15 LEU A 19 LEU A 51	MLY A 117 ( 4.3A) GOL A 127 ( 4.2A) GOL A 128 (-3.4A) MLY A 18 ( 4.6A) None	1.36A	3lcvB-3hsaA: undetectable	3lcvB-3hsaA: 16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MGH_A_ACTA1320_0 (PHOSPHORIBOSYLFORMYL GLYCINAMIDINE SYNTHASE)	3hsa	PLECKSTRIN HOMOLOGY DOMAIN (Shewanella amazonensis)	4 / 5	VAL A 45 LEU A 23 ILE A 54 LEU A 53	None None None MLY A 104 ( 4.8A)	0.87A	4mghA-3hsaA: undetectable	4mghA-3hsaA: 6.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JGL_A_SAMA301_1 (UBIE/COQ5 FAMILY METHYLTRANSFERASE, PUTATIVE)	3hsa	PLECKSTRIN HOMOLOGY DOMAIN (Shewanella amazonensis)	3 / 3	GLY A 114 ASP A 111 ASN A 10	MLY A 117 ( 4.4A) GOL A 126 (-3.9A) None	0.46A	5jglA-3hsaA: undetectable	5jglA-3hsaA: 19.86

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1EPB_A_9CRA165_1","EPIDIDYMAL RETINOIC ACID-BINDING PROTEIN","3hsa","PLECKSTRIN HOMOLOGY DOMAIN","Shewanella amazonensis",5,"ILE A  95;LEU A  53;ALA A 123;ILE A 119;ILE A 115","None;MLY A 104 ( 4.8A);None;None;None","0.97A","1epbA-3hsaA:undetectable","1epbA-3hsaA:22.29"],["3LCV_B_SAMB301_0","SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM","3hsa","PLECKSTRIN HOMOLOGY DOMAIN","Shewanella amazonensis",5,"THR A 118;ALA A  36;ASP A  15;LEU A  19;LEU A  51","MLY A 117 ( 4.3A);GOL A 127 ( 4.2A);GOL A 128 (-3.4A);MLY A  18 ( 4.6A);None","1.36A","3lcvB-3hsaA:undetectable","3lcvB-3hsaA:16.18"],["4MGH_A_ACTA1320_0","PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE","3hsa","PLECKSTRIN HOMOLOGY DOMAIN","Shewanella amazonensis",4,"VAL A  45;LEU A  23;ILE A  54;LEU A  53","None;None;None;MLY A 104 ( 4.8A)","0.87A","4mghA-3hsaA:undetectable","4mghA-3hsaA:6.29"],["5JGL_A_SAMA301_1","UBIE\/COQ5 FAMILY METHYLTRANSFERASE, PUTATIVE","3hsa","PLECKSTRIN HOMOLOGY DOMAIN","Shewanella amazonensis",3,"GLY A 114;ASP A 111;ASN A  10","MLY A 117 ( 4.4A);GOL A 126 (-3.9A);None","0.46A","5jglA-3hsaA:undetectable","5jglA-3hsaA:19.86"]]