SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hsi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_1
(TRANSTHYRETIN)		 3hsi PHOSPHATIDYLSERINE
SYNTHASE
(Haemophilus
influenzae) 		4 / 7 LEU A 373
LEU A 393
SER A 242
SER A 244
 None
 0.68A 1dvxA-3hsiA:
undetectable		 1dvxA-3hsiA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_B_MTXB352_1
(PTERIDINE REDUCTASE
1)		 3hsi PHOSPHATIDYLSERINE
SYNTHASE
(Haemophilus
influenzae) 		5 / 12 SER A 183
PHE A 187
TYR A 229
LEU A  85
LEU A 193
 None
 1.43A 1p33B-3hsiA:
undetectable		 1p33B-3hsiA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_0
(N,N-DIMETHYLGLYCINE
OXIDASE)		 3hsi PHOSPHATIDYLSERINE
SYNTHASE
(Haemophilus
influenzae) 		5 / 12 LEU A 256
GLY A 391
PHE A  18
LEU A  16
TYR A 371
 None
 1.30A 1pj7A-3hsiA:
undetectable		 1pj7A-3hsiA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_2
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 3hsi PHOSPHATIDYLSERINE
SYNTHASE
(Haemophilus
influenzae) 		4 / 7 VAL A 367
VAL A 405
TYR A 172
CYH A 274
 None
 1.27A 1t46A-3hsiA:
undetectable		 1t46A-3hsiA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_2
(CYTOCHROME P450 2C8)		 3hsi PHOSPHATIDYLSERINE
SYNTHASE
(Haemophilus
influenzae) 		4 / 8 ILE A  66
ILE A  70
ILE A 156
VAL A  82
 None
 0.71A 2nniA-3hsiA:
undetectable		 2nniA-3hsiA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 3hsi PHOSPHATIDYLSERINE
SYNTHASE
(Haemophilus
influenzae) 		4 / 8 LYS A 363
SER A 155
ASP A 170
ALA A  54
 None
 1.38A 2rk8A-3hsiA:
undetectable		 2rk8A-3hsiA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3hsi PHOSPHATIDYLSERINE
SYNTHASE
(Haemophilus
influenzae) 		4 / 8 TYR A 277
TYR A 328
ALA A 323
ALA A 321
 None
 1.04A 2wx2B-3hsiA:
undetectable		 2wx2B-3hsiA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJ8_C_SPMC500_1
(DIAMINE
ACETYLTRANSFERASE 1)		 3hsi PHOSPHATIDYLSERINE
SYNTHASE
(Haemophilus
influenzae) 		4 / 6 LEU A 192
ASP A  87
LEU A  55
HIS A 139
 None
 0.85A 3bj8C-3hsiA:
undetectable
3bj8D-3hsiA:
undetectable		 3bj8C-3hsiA:
17.78
3bj8D-3hsiA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DGQ_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 3hsi PHOSPHATIDYLSERINE
SYNTHASE
(Haemophilus
influenzae) 		4 / 5 TYR A 172
ARG A 171
ILE A 412
THR A 416
 None
 1.30A 3dgqA-3hsiA:
undetectable		 3dgqA-3hsiA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL5_B_1UNB201_1
(PROTEASE)		 3hsi PHOSPHATIDYLSERINE
SYNTHASE
(Haemophilus
influenzae) 		5 / 10 ALA A 105
ASP A 202
VAL A 203
GLY A 126
PRO A 207
 None
 1.14A 3el5A-3hsiA:
undetectable		 3el5A-3hsiA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		 3hsi PHOSPHATIDYLSERINE
SYNTHASE
(Haemophilus
influenzae) 		4 / 5 GLY A 153
ASP A 170
ARG A 171
GLN A  38
 None
 1.26A 3qx3A-3hsiA:
undetectable		 3qx3A-3hsiA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EVR_A_BEZA401_0
(PUTATIVE ABC
TRANSPORTER SUBUNIT,
SUBSTRATE-BINDING
COMPONENT)		 3hsi PHOSPHATIDYLSERINE
SYNTHASE
(Haemophilus
influenzae) 		5 / 11 LEU A 246
VAL A 259
TYR A 371
PHE A  18
SER A 244
 None
 1.31A 4evrA-3hsiA:
undetectable		 4evrA-3hsiA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		 3hsi PHOSPHATIDYLSERINE
SYNTHASE
(Haemophilus
influenzae) 		4 / 6 ASP A 182
ASN A 186
TYR A  51
ASP A 147
 None
 1.22A 4mdbA-3hsiA:
undetectable		 4mdbA-3hsiA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 3hsi PHOSPHATIDYLSERINE
SYNTHASE
(Haemophilus
influenzae) 		4 / 7 LYS A 305
TYR A 277
LEU A 332
PHE A 335
 None
 1.15A 4yv5B-3hsiA:
undetectable		 4yv5B-3hsiA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_E_ACTE406_0
(PROTON-GATED ION
CHANNEL)		 3hsi PHOSPHATIDYLSERINE
SYNTHASE
(Haemophilus
influenzae) 		4 / 5 ILE A  26
ILE A 372
ARG A 171
GLU A 408
 None
 1.00A 4zzcE-3hsiA:
undetectable		 4zzcE-3hsiA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 3hsi PHOSPHATIDYLSERINE
SYNTHASE
(Haemophilus
influenzae) 		4 / 5 THR A 275
GLY A 364
GLU A 389
HIS A 139
 None
 1.16A 5c0oH-3hsiA:
2.1		 5c0oH-3hsiA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_A_PAUA602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 3hsi PHOSPHATIDYLSERINE
SYNTHASE
(Haemophilus
influenzae) 		4 / 7 GLU A 261
GLY A 253
GLY A 248
ALA A 251
 None
 0.77A 5e26A-3hsiA:
undetectable
5e26B-3hsiA:
undetectable		 5e26A-3hsiA:
23.19
5e26B-3hsiA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_B_PAUB601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 3hsi PHOSPHATIDYLSERINE
SYNTHASE
(Haemophilus
influenzae) 		4 / 7 ALA A 251
GLU A 261
GLY A 253
GLY A 248
 None
 0.73A 5e26A-3hsiA:
undetectable
5e26B-3hsiA:
undetectable		 5e26A-3hsiA:
23.19
5e26B-3hsiA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_C_PAUC602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 3hsi PHOSPHATIDYLSERINE
SYNTHASE
(Haemophilus
influenzae) 		4 / 7 GLU A 261
GLY A 253
GLY A 248
ALA A 251
 None
 0.74A 5e26C-3hsiA:
undetectable
5e26D-3hsiA:
undetectable		 5e26C-3hsiA:
23.19
5e26D-3hsiA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_D_PAUD601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 3hsi PHOSPHATIDYLSERINE
SYNTHASE
(Haemophilus
influenzae) 		4 / 8 ALA A 251
GLU A 261
GLY A 253
GLY A 248
 None
 0.75A 5e26C-3hsiA:
undetectable
5e26D-3hsiA:
undetectable		 5e26C-3hsiA:
23.19
5e26D-3hsiA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_B_ADNB503_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 3hsi PHOSPHATIDYLSERINE
SYNTHASE
(Haemophilus
influenzae) 		4 / 5 LEU A 373
VAL A 259
GLU A 255
LEU A 246
 None
 1.07A 5xooB-3hsiA:
undetectable		 5xooB-3hsiA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DYO_A_LDPA901_0
(EBONY)		 3hsi PHOSPHATIDYLSERINE
SYNTHASE
(Haemophilus
influenzae) 		4 / 5 GLU A 133
VAL A 137
LEU A  55
HIS A 361
 None
 1.24A 6dyoA-3hsiA:
undetectable		 6dyoA-3hsiA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 3hsi PHOSPHATIDYLSERINE
SYNTHASE
(Haemophilus
influenzae) 		5 / 12 TRP A 384
ASN A 254
ASP A 387
LEU A 386
ASN A 380
 None
 1.20A 6r2eA-3hsiA:
undetectable		 6r2eA-3hsiA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_C_FFOC404_0
(THYMIDYLATE SYNTHASE)		 3hsi PHOSPHATIDYLSERINE
SYNTHASE
(Haemophilus
influenzae) 		5 / 10 TRP A 384
ASN A 254
ASP A 387
LEU A 386
ASN A 380
 None
 1.22A 6r2eC-3hsiA:
undetectable		 6r2eC-3hsiA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_F_FFOF403_0
(THYMIDYLATE SYNTHASE)		 3hsi PHOSPHATIDYLSERINE
SYNTHASE
(Haemophilus
influenzae) 		5 / 11 TRP A 384
ASN A 254
ASP A 387
LEU A 386
ASN A 380
 None
 1.25A 6r2eF-3hsiA:
undetectable		 6r2eF-3hsiA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_G_FFOG403_0
(THYMIDYLATE SYNTHASE)		 3hsi PHOSPHATIDYLSERINE
SYNTHASE
(Haemophilus
influenzae) 		5 / 11 TRP A 384
ASN A 254
ASP A 387
LEU A 386
ASN A 380
 None
 1.23A 6r2eG-3hsiA:
undetectable		 6r2eG-3hsiA:
20.68