SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hsk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4001_1
(SERUM ALBUMIN)		 3hsk ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Candida
albicans) 		4 / 5 LYS A 109
ALA A 108
ASP A  88
GLY A  91
 None
 1.15A 1e7bA-3hskA:
undetectable		 1e7bA-3hskA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4001_1
(SERUM ALBUMIN)		 3hsk ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Candida
albicans) 		4 / 5 LYS A 109
ALA A 108
ASP A  88
GLY A  91
 None
 1.17A 1e7cA-3hskA:
undetectable		 1e7cA-3hskA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_H_ACTH3006_0
(BETA-CARBONIC
ANHYDRASE)		 3hsk ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Candida
albicans) 		4 / 6 GLN A  67
CYH A  78
VAL A  81
HIS A  32
 None
 1.44A 1ekjG-3hskA:
undetectable
1ekjH-3hskA:
undetectable		 1ekjG-3hskA:
20.26
1ekjH-3hskA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_B_ESTB354_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 3hsk ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Candida
albicans) 		4 / 8 LEU A 223
PRO A 164
MET A 241
VAL A 243
 None
 0.96A 1fduB-3hskA:
6.7		 1fduB-3hskA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 3hsk ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Candida
albicans) 		5 / 10 SER A 106
SER A  83
ASN A 107
GLY A  16
GLY A   7
 None
 1.32A 1mehA-3hskA:
undetectable		 1mehA-3hskA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_2
(ANGIOTENSIN
CONVERTING ENZYME)		 3hsk ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Candida
albicans) 		4 / 4 SER A 106
VAL A 120
PHE A  19
VAL A  15
 None
 1.42A 1o86A-3hskA:
undetectable		 1o86A-3hskA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB504_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3hsk ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Candida
albicans) 		4 / 7 LEU A 289
ILE A 358
ALA A 285
PRO A 126
 None
 0.74A 1oniB-3hskA:
2.6
1oniC-3hskA:
undetectable		 1oniB-3hskA:
18.09
1oniC-3hskA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_C_SAMC303_0
(HEMK PROTEIN)		 3hsk ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Candida
albicans) 		6 / 12 PHE A  75
PRO A  71
ILE A 365
ALA A 100
VAL A 105
SER A 106
 None
 1.39A 1sg9C-3hskA:
3.6		 1sg9C-3hskA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVS_B_MK1B902_3
(POL POLYPROTEIN)		 3hsk ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Candida
albicans) 		5 / 12 GLY A  10
ALA A  11
ILE A  31
GLY A   7
VAL A  81
 NAP  A 366 (-3.3A)
None
None
None
None
 1.12A 2avsB-3hskA:
undetectable		 2avsB-3hskA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 3hsk ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Candida
albicans) 		5 / 12 ILE A 150
ALA A 103
LEU A 359
PRO A 126
ASN A 125
 None
 1.44A 3eigA-3hskA:
undetectable		 3eigA-3hskA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3hsk ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Candida
albicans) 		3 / 3 ASN A 343
HIS A 342
VAL A 322
 None
 0.85A 3elzB-3hskA:
undetectable		 3elzB-3hskA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3hsk ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Candida
albicans) 		4 / 7 ILE A 364
PHE A  29
PHE A  82
GLY A 148
 None
 0.91A 3em0B-3hskA:
undetectable		 3em0B-3hskA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_1
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 3hsk ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Candida
albicans) 		3 / 3 TYR A 111
ASP A  92
ASP A  88
 None
 0.85A 4a6eA-3hskA:
undetectable		 4a6eA-3hskA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_2
(ADENOSINE KINASE)		 3hsk ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Candida
albicans) 		4 / 5 LEU A 102
SER A  96
LEU A   9
LEU A  76
 None
 1.31A 4n09D-3hskA:
3.8		 4n09D-3hskA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 3hsk ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Candida
albicans) 		3 / 3 VAL A   8
ALA A  36
PHE A  75
 None
NAP  A 366 (-3.4A)
None
 0.94A 4w5nA-3hskA:
2.7		 4w5nA-3hskA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQY_A_BEZA401_0
(THIOREDOXIN)		 3hsk ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Candida
albicans) 		4 / 8 LYS A   2
PHE A  29
VAL A  80
GLU A  28
 None
 1.03A 5dqyA-3hskA:
undetectable		 5dqyA-3hskA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FUK_A_SNPA1236_1
(MROUPO)		 3hsk ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Candida
albicans) 		4 / 7 ILE A 353
ILE A 358
ILE A 151
PHE A  82
 None
 0.81A 5fukA-3hskA:
undetectable
5fukB-3hskA:
undetectable		 5fukA-3hskA:
22.70
5fukB-3hskA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNW_D_GCSD302_1
(25 KDA PROTEIN
ELICITOR)		 3hsk ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Candida
albicans) 		4 / 7 ASP A 317
GLY A 319
HIS A 342
ASP A 313
 None
 1.04A 5nnwD-3hskA:
undetectable		 5nnwD-3hskA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NO9_D_95ZD302_1
(25 KDA PROTEIN
ELICITOR)		 3hsk ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Candida
albicans) 		4 / 7 ASP A 317
GLY A 319
HIS A 342
ASP A 313
 None
 1.08A 5no9D-3hskA:
undetectable		 5no9D-3hskA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 3hsk ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Candida
albicans) 		5 / 12 PHE A  19
VAL A   8
ALA A  36
TYR A  45
GLY A  10
 None
None
NAP  A 366 (-3.4A)
None
NAP  A 366 (-3.3A)
 1.27A 5tzoA-3hskA:
undetectable		 5tzoA-3hskA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 3hsk ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Candida
albicans) 		5 / 12 PHE A  19
VAL A   8
ALA A  36
TYR A  45
GLY A  10
 None
None
NAP  A 366 (-3.4A)
None
NAP  A 366 (-3.3A)
 1.25A 5tzoC-3hskA:
undetectable		 5tzoC-3hskA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 3hsk ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Candida
albicans) 		5 / 12 SER A 106
GLY A  10
ALA A  36
PHE A  97
SER A  96
 None
NAP  A 366 (-3.3A)
NAP  A 366 (-3.4A)
None
None
 1.42A 5wbvA-3hskA:
undetectable		 5wbvA-3hskA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 3hsk ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Candida
albicans) 		5 / 12 SER A 106
GLY A  10
ALA A  36
PHE A  97
SER A  96
 None
NAP  A 366 (-3.3A)
NAP  A 366 (-3.4A)
None
None
 1.40A 5wbvB-3hskA:
undetectable		 5wbvB-3hskA:
21.45