SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hst'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_A_SAMA5635_0
(PROTEIN RDMB)		 3hst PROTEIN
RV2228C/MT2287
(Mycobacterium
tuberculosis) 		5 / 12 GLY B   9
GLY B  52
ASP B 128
SER B  74
ASN B 119
 None
 1.08A 1xdsA-3hstB:
2.2		 1xdsA-3hstB:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_B_SAMB9635_0
(PROTEIN RDMB)		 3hst PROTEIN
RV2228C/MT2287
(Mycobacterium
tuberculosis) 		6 / 12 GLY B   9
GLY B  52
LEU B 125
ASP B 128
SER B  74
ASN B 119
 None
 1.32A 1xdsB-3hstB:
undetectable		 1xdsB-3hstB:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3hst PROTEIN
RV2228C/MT2287
(Mycobacterium
tuberculosis) 		5 / 12 GLY B  10
GLY B  52
GLY B  19
LEU B  57
ASP B   8
 None
 1.00A 2oxtA-3hstB:
undetectable		 2oxtA-3hstB:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_1
(PUTATIVE
MODIFICATION
METHYLASE)		 3hst PROTEIN
RV2228C/MT2287
(Mycobacterium
tuberculosis) 		3 / 3 ASP B 128
THR B  31
GLU B  35
 None
 0.75A 2zifB-3hstB:
undetectable		 2zifB-3hstB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_0
(MNMC2)		 3hst PROTEIN
RV2228C/MT2287
(Mycobacterium
tuberculosis) 		5 / 12 GLY B  52
GLY B  21
LEU B 125
GLU B   6
LEU B  57
 None
 1.10A 3vywA-3hstB:
2.1		 3vywA-3hstB:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_A_PAUA602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 3hst PROTEIN
RV2228C/MT2287
(Mycobacterium
tuberculosis) 		4 / 7 GLU B  49
GLY B  21
GLY B  56
ALA B 122
 None
 0.92A 5e26A-3hstB:
3.6
5e26B-3hstB:
3.5		 5e26A-3hstB:
19.17
5e26B-3hstB:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_2
(PROTEASE PR5-DRV)		 3hst PROTEIN
RV2228C/MT2287
(Mycobacterium
tuberculosis) 		5 / 8 ALA B 132
ASP B 131
ASP B 128
GLY B  19
ILE B  40
 None
 1.24A 5kr1B-3hstB:
undetectable		 5kr1B-3hstB:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_A_ROCA101_1
(PROTEASE PR5-SQV)		 3hst PROTEIN
RV2228C/MT2287
(Mycobacterium
tuberculosis) 		5 / 9 ALA B 132
ASP B 131
ASP B 128
GLY B  19
ILE B  40
 None
 1.21A 5kr2A-3hstB:
undetectable		 5kr2A-3hstB:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_C_ROCC101_1
(PROTEASE PR5-SQV)		 3hst PROTEIN
RV2228C/MT2287
(Mycobacterium
tuberculosis) 		5 / 9 ALA B 132
ASP B 131
ASP B 128
GLY B  19
ILE B  40
 None
 1.23A 5kr2C-3hstB:
undetectable		 5kr2C-3hstB:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_A_ADNA401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 3hst PROTEIN
RV2228C/MT2287
(Mycobacterium
tuberculosis) 		4 / 7 GLY B  10
GLU B  49
ASP B 123
ASN B  14
 None
 0.98A 5mvsA-3hstB:
undetectable		 5mvsA-3hstB:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_B_ADNB401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 3hst PROTEIN
RV2228C/MT2287
(Mycobacterium
tuberculosis) 		4 / 8 GLY B  10
GLU B  49
ASP B 123
ASN B  14
 None
 0.96A 5mvsB-3hstB:
undetectable		 5mvsB-3hstB:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_0
(METHYLTRANSFERASE)		 3hst PROTEIN
RV2228C/MT2287
(Mycobacterium
tuberculosis) 		5 / 12 ALA B  99
GLY B  56
TYR B  50
ALA B  34
ALA B  60
 None
 1.19A 5n5dA-3hstB:
undetectable		 5n5dA-3hstB:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_B_IXXB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 3hst PROTEIN
RV2228C/MT2287
(Mycobacterium
tuberculosis) 		4 / 5 ALA B  48
TYR B  20
GLN B  98
ILE B  54
 None
 0.89A 6g9bA-3hstB:
undetectable
6g9bB-3hstB:
undetectable		 6g9bA-3hstB:
20.00
6g9bB-3hstB:
20.63