SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hsy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3hsy GLUTAMATE RECEPTOR 2
(Rattus
norvegicus) 		4 / 6 ALA A 217
TYR A 129
ILE A 216
ILE A 187
 None
 1.22A 2dcfA-3hsyA:
undetectable		 2dcfA-3hsyA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA310_1
(BETA-LACTAMASE)		 3hsy GLUTAMATE RECEPTOR 2
(Rattus
norvegicus) 		4 / 8 ALA A 277
THR A 279
GLY A  15
PRO A  13
 None
 0.94A 3ny4A-3hsyA:
undetectable		 3ny4A-3hsyA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3hsy GLUTAMATE RECEPTOR 2
(Rattus
norvegicus) 		3 / 3 SER A  75
ASP A 134
ASP A 193
 None
 0.81A 3uj7A-3hsyA:
undetectable		 3uj7A-3hsyA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 3hsy GLUTAMATE RECEPTOR 2
(Rattus
norvegicus) 		5 / 12 PRO A  13
PHE A  70
PRO A  93
LEU A 278
TYR A 274
 None
 1.20A 4a84A-3hsyA:
undetectable		 4a84A-3hsyA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A602_1
(SERUM ALBUMIN)		 3hsy GLUTAMATE RECEPTOR 2
(Rattus
norvegicus) 		4 / 7 VAL A 285
MET A 286
ALA A 289
PHE A 290
 None
 0.89A 4lb2A-3hsyA:
undetectable		 4lb2A-3hsyA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3hsy GLUTAMATE RECEPTOR 2
(Rattus
norvegicus) 		5 / 12 ILE A 354
ARG A 108
PHE A 239
ILE A 187
LEU A 115
 None
SO4  A 384 (-2.5A)
None
None
None
 1.07A 4m6kA-3hsyA:
2.3		 4m6kA-3hsyA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 3hsy GLUTAMATE RECEPTOR 2
(Rattus
norvegicus) 		3 / 3 SER A  75
ASP A 134
ASP A 193
 None
 0.87A 4mwzA-3hsyA:
undetectable		 4mwzA-3hsyA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA306_1
(CHITOSANASE)		 3hsy GLUTAMATE RECEPTOR 2
(Rattus
norvegicus) 		3 / 3 SER A 138
ASP A  98
GLN A 106
 None
 0.77A 4oltA-3hsyA:
undetectable
4oltB-3hsyA:
undetectable		 4oltA-3hsyA:
22.75
4oltB-3hsyA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB304_1
(CHITOSANASE)		 3hsy GLUTAMATE RECEPTOR 2
(Rattus
norvegicus) 		3 / 3 GLN A 106
SER A 138
ASP A  98
 None
 0.73A 4qwpA-3hsyA:
undetectable
4qwpB-3hsyA:
undetectable		 4qwpA-3hsyA:
22.75
4qwpB-3hsyA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_2
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 3hsy GLUTAMATE RECEPTOR 2
(Rattus
norvegicus) 		4 / 5 ILE A 352
HIS A 213
TYR A 129
VAL A 143
 None
NAG  A 383 (-3.8A)
None
None
 1.14A 4s0vA-3hsyA:
5.2		 4s0vA-3hsyA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 3hsy GLUTAMATE RECEPTOR 2
(Rattus
norvegicus) 		5 / 12 VAL A 285
ILE A  91
ILE A 339
GLY A 337
VAL A 249
 None
 1.03A 4y8wC-3hsyA:
undetectable		 4y8wC-3hsyA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 3hsy GLUTAMATE RECEPTOR 2
(Rattus
norvegicus) 		4 / 5 THR A 269
ALA A 270
THR A 271
TYR A 244
 None
 1.26A 5ecmA-3hsyA:
undetectable		 5ecmA-3hsyA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 3hsy GLUTAMATE RECEPTOR 2
(Rattus
norvegicus) 		3 / 3 ALA A 289
ASN A 292
LEU A 293
 None
 0.48A 5i1nC-3hsyA:
undetectable		 5i1nC-3hsyA:
6.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 3hsy GLUTAMATE RECEPTOR 2
(Rattus
norvegicus) 		3 / 3 ALA A 289
ASN A 292
LEU A 293
 None
 0.39A 5i1pA-3hsyA:
undetectable		 5i1pA-3hsyA:
6.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 3hsy GLUTAMATE RECEPTOR 2
(Rattus
norvegicus) 		3 / 3 ALA A 289
ASN A 292
LEU A 293
 None
 0.47A 5i1pD-3hsyA:
undetectable		 5i1pD-3hsyA:
6.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA809_1
(CATALASE-PEROXIDASE)		 3hsy GLUTAMATE RECEPTOR 2
(Rattus
norvegicus) 		4 / 8 GLY A 136
GLN A 141
LEU A 137
THR A 139
 None
 1.11A 5syjA-3hsyA:
undetectable		 5syjA-3hsyA:
19.65