SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3htk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGZ_D_COCD401_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3htk E3 SUMO-PROTEIN
LIGASE MMS21
(Saccharomyces
cerevisiae) 		4 / 6 TYR C  76
TYR C  34
GLN C  36
ILE C  33
 None
 1.38A 2pgzD-3htkC:
undetectable
2pgzE-3htkC:
undetectable		 2pgzD-3htkC:
21.83
2pgzE-3htkC:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_C_9PLC501_1
(CYTOCHROME P450 2E1)		 3htk E3 SUMO-PROTEIN
LIGASE MMS21
STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
5
(Saccharomyces
cerevisiae) 		4 / 5 PHE A 342
ALA B 766
THR C  69
LEU A 345
 None
 1.15A 3t3zC-3htkA:
undetectable		 3t3zC-3htkA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 3htk E3 SUMO-PROTEIN
LIGASE MMS21
(Saccharomyces
cerevisiae) 		4 / 8 LEU C 150
THR C 158
ASP C 156
TYR C 152
 None
 1.05A 4drjB-3htkC:
2.1		 4drjB-3htkC:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3htk E3 SUMO-PROTEIN
LIGASE MMS21
(Saccharomyces
cerevisiae) 		4 / 4 PRO C 167
LEU C 164
ILE C 161
ARG C 244
 None
 1.28A 4f4dA-3htkC:
undetectable		 4f4dA-3htkC:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUK_A_RBFA201_1
(BLUE-LIGHT
PHOTORECEPTOR)		 3htk E3 SUMO-PROTEIN
LIGASE MMS21
(Saccharomyces
cerevisiae) 		5 / 12 VAL C 236
SER C 197
ASN C 201
GLN C 165
ASN C 140
 None
 1.36A 4kukA-3htkC:
undetectable		 4kukA-3htkC:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DHB_A_BEZA202_0
(HEPATITIS A VIRUS
CELLULAR RECEPTOR 2)		 3htk STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
5
(Saccharomyces
cerevisiae) 		4 / 6 ILE B 800
MET B 796
ASN B 797
ASP B 793
 None
 1.21A 6dhbA-3htkB:
undetectable		 6dhbA-3htkB:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA717_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 3htk E3 SUMO-PROTEIN
LIGASE MMS21
(Saccharomyces
cerevisiae) 		4 / 5 SER C 231
ARG C 233
ASP C 234
LYS C 199
 None
 1.26A 6dwdA-3htkC:
undetectable		 6dwdA-3htkC:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA717_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 3htk E3 SUMO-PROTEIN
LIGASE MMS21
(Saccharomyces
cerevisiae) 		4 / 5 SER C 231
ASP C 234
ARG C 198
LYS C 199
 None
 1.41A 6dwdA-3htkC:
undetectable		 6dwdA-3htkC:
18.95