SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3htn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_2
(PROTEIN (HIV-1
PROTEASE))		 3htn PUTATIVE DNA BINDING
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 8 LEU A 117
GLY A  89
ILE A 152
ILE A 114
 None
 0.67A 1d4yB-3htnA:
undetectable		 1d4yB-3htnA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_1
(HIV-1 PROTEASE)		 3htn PUTATIVE DNA BINDING
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 9 LEU A 117
GLY A 157
GLY A  89
ILE A 152
ILE A 114
 None
 1.02A 1hpvA-3htnA:
undetectable		 1hpvA-3htnA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEI_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 3htn PUTATIVE DNA BINDING
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 8 SER A  81
ASN A 120
ILE A 121
GLY A  84
 None
 0.96A 1meiA-3htnA:
undetectable		 1meiA-3htnA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_B_ACTB1108_0
(C5A PEPTIDASE)		 3htn PUTATIVE DNA BINDING
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 6 LEU A 132
GLY A 119
ASN A  83
PHE A 159
 None
 0.81A 1xf1B-3htnA:
undetectable		 1xf1B-3htnA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDW_B_017B401_1
(PROTEASE)		 3htn PUTATIVE DNA BINDING
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 11 LEU A 117
VAL A 136
GLY A  89
ILE A 152
ILE A 114
 None
 1.14A 2idwA-3htnA:
undetectable		 2idwA-3htnA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_1
(PROTEASE)		 3htn PUTATIVE DNA BINDING
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 12 LEU A 117
GLY A 157
ILE A 152
ILE A 134
ILE A 114
 None
 0.86A 3s54A-3htnA:
undetectable		 3s54A-3htnA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_3
(PROTEASE)		 3htn PUTATIVE DNA BINDING
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 12 LEU A 117
GLY A 157
GLY A  89
ILE A 152
ILE A 114
 None
 0.86A 3tl9B-3htnA:
undetectable		 3tl9B-3htnA:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF2_A_4CHA506_0
(NADPH DEHYDROGENASE)		 3htn PUTATIVE DNA BINDING
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 6 TYR A 129
HIS A 147
HIS A 133
TYR A 181
 None
NI  A 201 ( 3.3A)
NI  A 201 (-3.4A)
None
 1.45A 4df2A-3htnA:
undetectable		 4df2A-3htnA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_2
(PROTEASE)		 3htn PUTATIVE DNA BINDING
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 12 LEU A 117
GLY A 157
ILE A 152
ILE A 134
ILE A 114
 None
 0.84A 5e5jB-3htnA:
undetectable		 5e5jB-3htnA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5K_B_017B201_2
(HIV-1 PROTEASE)		 3htn PUTATIVE DNA BINDING
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 12 LEU A 117
GLY A 157
ILE A 152
ILE A 134
ILE A 114
 None
 0.91A 5e5kB-3htnA:
undetectable		 5e5kB-3htnA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSN_A_MMZA503_1
(FLAVIN-CONTAINING
MONOOXYGENASE)		 3htn PUTATIVE DNA BINDING
PROTEIN
(Bacteroides
thetaiotaomicron) 		3 / 3 ASN A 120
SER A 122
SER A  79
 None
 0.73A 5gsnA-3htnA:
undetectable		 5gsnA-3htnA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 3htn PUTATIVE DNA BINDING
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 12 ILE A  88
LEU A 148
GLU A 110
ARG A 109
GLY A  89
 None
 1.34A 5k7uA-3htnA:
undetectable		 5k7uA-3htnA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_2
(PROTEASE E35D-SQV)		 3htn PUTATIVE DNA BINDING
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 9 LEU A 117
VAL A 136
GLY A  89
ILE A 152
ILE A 114
 None
 1.13A 5kqxB-3htnA:
undetectable		 5kqxB-3htnA:
22.88