SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3htu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_1
(ESTROGEN RECEPTOR)		 3htu VACUOLAR
PROTEIN-SORTING-ASSO
CIATED PROTEIN 25
(Homo
sapiens) 		4 / 6 ALA A 147
ASP A 145
GLU A 146
ARG A 171
 None
 1.21A 2ouzA-3htuA:
undetectable		 2ouzA-3htuA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_P_ASDP1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3htu VACUOLAR
PROTEIN-SORTING-ASSO
CIATED PROTEIN 25
(Homo
sapiens) 		4 / 8 PHE A 175
LEU A 149
LEU A 150
ALA A 162
 None
 0.77A 2vcvP-3htuA:
undetectable		 2vcvP-3htuA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL3_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3htu VACUOLAR
PROTEIN-SORTING-ASSO
CIATED PROTEIN 25
VACUOLAR
PROTEIN-SORTING-ASSO
CIATED PROTEIN 20
(Homo
sapiens;
Homo
sapiens) 		5 / 12 ILE A 164
ALA A 162
LEU A 130
ARG B  27
ILE A 165
 None
 1.22A 3ql3A-3htuA:
undetectable		 3ql3A-3htuA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 3htu VACUOLAR
PROTEIN-SORTING-ASSO
CIATED PROTEIN 25
(Homo
sapiens) 		4 / 6 PHE A 175
ALA A 162
GLY A 108
LEU A 153
 None
 0.84A 4dubA-3htuA:
undetectable		 4dubA-3htuA:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 3htu VACUOLAR
PROTEIN-SORTING-ASSO
CIATED PROTEIN 25
(Homo
sapiens) 		4 / 6 PHE A 175
ALA A 162
GLY A 108
LEU A 153
 None
 0.85A 4dubB-3htuA:
undetectable		 4dubB-3htuA:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_B_STRB301_1
(STEROID RECEPTOR 2)		 3htu VACUOLAR
PROTEIN-SORTING-ASSO
CIATED PROTEIN 25
(Homo
sapiens) 		5 / 12 LEU A 150
LEU A 153
LEU A 156
ALA A 162
THR A 166
 None
 1.20A 4fn9B-3htuA:
undetectable		 4fn9B-3htuA:
15.87