SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3htz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		 3htz ALANYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		5 / 12 ASP A 271
ILE A 298
ILE A 295
ALA A 279
THR A  88
 None
 1.29A 1kijB-3htzA:
undetectable		 1kijB-3htzA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RKW_A_PNTA225_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 3htz ALANYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		5 / 12 GLU A 156
TYR A 176
SER A 128
TYR A 130
ASN A 194
 None
 1.40A 1rkwA-3htzA:
1.5		 1rkwA-3htzA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A7Q_A_CFBA328_2
(DEOXYCYTIDINE KINASE)		 3htz ALANYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		4 / 4 ILE A 295
ASP A 271
LEU A 316
ARG A 297
 None
 1.25A 2a7qA-3htzA:
undetectable		 2a7qA-3htzA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EFJ_A_37TA502_1
(3,7-DIMETHYLXANTHINE
METHYLTRANSFERASE)		 3htz ALANYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		5 / 12 LEU A 417
PHE A 413
ILE A 397
ILE A 363
TYR A 387
 None
 1.39A 2efjA-3htzA:
2.0		 2efjA-3htzA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 3htz ALANYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		5 / 12 PHE A  46
ALA A  61
PRO A  45
GLY A  42
GLY A  94
 None
 1.15A 2igtA-3htzA:
undetectable		 2igtA-3htzA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 3htz ALANYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		5 / 12 PHE A  46
ALA A  61
PRO A  45
GLY A  42
GLY A  94
 None
 1.14A 2igtB-3htzA:
undetectable		 2igtB-3htzA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_E_MTXE621_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3htz ALANYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		5 / 12 ALA A 226
LEU A 118
LYS A 119
ILE A 175
LEU A 125
 None
 1.08A 2oipE-3htzA:
undetectable		 2oipE-3htzA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3htz ALANYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		5 / 6 LEU A  77
ARG A 297
ILE A 298
ILE A 311
LEU A 266
 None
 1.31A 2xkwB-3htzA:
undetectable		 2xkwB-3htzA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_2
(CYTOCHROME P450 3A4)		 3htz ALANYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		4 / 7 ARG A 304
LEU A 316
THR A  88
ARG A 297
 None
 1.24A 3nxuA-3htzA:
undetectable		 3nxuA-3htzA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 3htz ALANYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		4 / 5 PHE A 315
LEU A 356
ILE A 269
VAL A 268
 None
 0.83A 3wrkA-3htzA:
undetectable		 3wrkA-3htzA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3htz ALANYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		5 / 12 LEU A 125
VAL A 127
SER A 128
ALA A 136
PHE A 197
 None
 1.24A 4ib4A-3htzA:
2.6		 4ib4A-3htzA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KHP_A_PARA1606_1
(16S RIBOSOMAL RNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 3htz ALANYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		3 / 3 TYR A 439
ARG A 421
SER A 440
 None
 1.03A 4khpI-3htzA:
undetectable
4khpJ-3htzA:
undetectable		 4khpI-3htzA:
15.68
4khpJ-3htzA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3htz ALANYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		4 / 7 LEU A  28
ARG A 274
SER A  63
MET A  92
 None
 1.24A 4klrA-3htzA:
undetectable		 4klrA-3htzA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 3htz ALANYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		4 / 6 TRP A 140
ILE A 175
HIS A  20
VAL A 117
 None
 0.86A 4zj8A-3htzA:
3.0		 4zj8A-3htzA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_F_MFXF2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 3htz ALANYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		4 / 6 ASP A 178
ARG A 188
GLY A 185
GLU A 184
 None
 1.03A 5cdqA-3htzA:
undetectable
5cdqC-3htzA:
undetectable
5cdqD-3htzA:
undetectable		 5cdqA-3htzA:
23.38
5cdqC-3htzA:
23.38
5cdqD-3htzA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IL1_A_SAMA601_0
(METTL3)		 3htz ALANYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		5 / 12 ILE A 225
LEU A 118
GLU A 191
ASN A 194
GLY A 221
 None
 1.29A 5il1A-3htzA:
undetectable		 5il1A-3htzA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA609_0
(NADH DEHYDROGENASE,
PUTATIVE)		 3htz ALANYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		3 / 3 VAL A 129
SER A 128
TRP A 140
 None
 0.94A 5jwaA-3htzA:
undetectable		 5jwaA-3htzA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 3htz ALANYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		5 / 12 ILE A 225
LEU A 118
GLU A 191
ASN A 194
GLY A 221
 None
 1.33A 5k7uA-3htzA:
undetectable		 5k7uA-3htzA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_2
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 3htz ALANYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		3 / 3 VAL A 438
ARG A 301
PRO A 393
 None
 0.85A 5koxA-3htzA:
undetectable		 5koxA-3htzA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA406_0
(THIOREDOXIN
REDUCTASE)		 3htz ALANYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		3 / 3 HIS A  86
SER A  84
ARG A 224
 None
 0.90A 5u63A-3htzA:
undetectable		 5u63A-3htzA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_F_D16F402_1
(THYMIDYLATE SYNTHASE)		 3htz ALANYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		4 / 8 ARG A 267
LEU A 309
GLY A 306
PHE A 305
 None
 0.89A 5x5qF-3htzA:
undetectable		 5x5qF-3htzA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA608_0
(ALPHA-AMYLASE)		 3htz ALANYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		4 / 6 PHE A  11
GLY A  94
THR A  62
TYR A 101
 None
 1.22A 6ag0A-3htzA:
undetectable		 6ag0A-3htzA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC606_0
(ALPHA-AMYLASE)		 3htz ALANYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		4 / 6 PHE A  11
GLY A  94
THR A  62
TYR A 101
 None
 1.22A 6ag0C-3htzA:
undetectable		 6ag0C-3htzA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_2
(TUBULIN BETA CHAIN)		 3htz ALANYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		4 / 5 LEU A  68
THR A 277
ARG A 301
ARG A 267
 None
 1.00A 6ew0B-3htzA:
undetectable		 6ew0B-3htzA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_2
(TUBULIN BETA CHAIN)		 3htz ALANYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		4 / 5 LEU A  68
THR A 277
ARG A 301
ARG A 267
 None
 1.00A 6ew0D-3htzA:
undetectable		 6ew0D-3htzA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_2
(TUBULIN BETA CHAIN)		 3htz ALANYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		4 / 6 LEU A  68
THR A 277
ARG A 301
ARG A 267
 None
 1.01A 6ew0G-3htzA:
undetectable		 6ew0G-3htzA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_2
(TUBULIN BETA CHAIN)		 3htz ALANYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		4 / 5 LEU A  68
THR A 277
ARG A 301
ARG A 267
 None
 1.01A 6ew0H-3htzA:
undetectable		 6ew0H-3htzA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_2
(TUBULIN BETA CHAIN)		 3htz ALANYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		4 / 5 LEU A  68
THR A 277
ARG A 301
ARG A 267
 None
 1.00A 6ew0I-3htzA:
undetectable		 6ew0I-3htzA:
14.50