SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hu5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3hu5 ISOCHORISMATASE
FAMILY PROTEIN
(Desulfovibrio
vulgaris) 		3 / 3 SER A 162
ASP A  15
CYH A  82
 None
 1.13A 2br4E-3hu5A:
3.3		 2br4E-3hu5A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3hu5 ISOCHORISMATASE
FAMILY PROTEIN
(Desulfovibrio
vulgaris) 		4 / 6 LEU A  22
VAL A 131
ILE A  39
ARG A 141
 None
 0.92A 2hyyA-3hu5A:
undetectable		 2hyyA-3hu5A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_2
(PROTEASE)		 3hu5 ISOCHORISMATASE
FAMILY PROTEIN
(Desulfovibrio
vulgaris) 		3 / 3 ARG A  58
VAL A 131
THR A 143
 None
 0.84A 2nmzA-3hu5A:
undetectable		 2nmzA-3hu5A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_2
(PROTEASE)		 3hu5 ISOCHORISMATASE
FAMILY PROTEIN
(Desulfovibrio
vulgaris) 		3 / 3 ARG A  58
VAL A 131
THR A 143
 None
 0.83A 2nnkA-3hu5A:
undetectable		 2nnkA-3hu5A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_B_REAB1445_1
(PUTATIVE CYTOCHROME
P450 120)		 3hu5 ISOCHORISMATASE
FAMILY PROTEIN
(Desulfovibrio
vulgaris) 		5 / 12 ALA A  12
PHE A 112
ALA A 147
VAL A 126
GLY A 125
 None
 1.27A 2ve3B-3hu5A:
undetectable		 2ve3B-3hu5A:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FBX_A_ACTA608_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2)		 3hu5 ISOCHORISMATASE
FAMILY PROTEIN
(Desulfovibrio
vulgaris) 		3 / 3 GLU A  30
VAL A  29
CYH A  28
 None
 1.06A 3fbxA-3hu5A:
undetectable		 3fbxA-3hu5A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_2
(HIV-1 PROTEASE)		 3hu5 ISOCHORISMATASE
FAMILY PROTEIN
(Desulfovibrio
vulgaris) 		3 / 3 ARG A  58
VAL A 131
THR A 143
 None
 0.85A 3k4vA-3hu5A:
undetectable		 3k4vA-3hu5A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_2
(PROTEASE)		 3hu5 ISOCHORISMATASE
FAMILY PROTEIN
(Desulfovibrio
vulgaris) 		3 / 3 ARG A  58
VAL A 131
THR A 143
 None
 0.74A 3ndtA-3hu5A:
undetectable		 3ndtA-3hu5A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_2
(PROTEASE)		 3hu5 ISOCHORISMATASE
FAMILY PROTEIN
(Desulfovibrio
vulgaris) 		3 / 3 ARG A  58
VAL A 131
THR A 143
 None
 0.86A 3pwrA-3hu5A:
undetectable		 3pwrA-3hu5A:
19.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R2J_C_NIOC311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)		 3hu5 ISOCHORISMATASE
FAMILY PROTEIN
(Desulfovibrio
vulgaris) 		5 / 12 ASP A  15
PHE A  20
HIS A  60
LYS A 106
CYH A 139
 None
 0.99A 3r2jC-3hu5A:
23.8		 3r2jC-3hu5A:
30.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3hu5 ISOCHORISMATASE
FAMILY PROTEIN
(Desulfovibrio
vulgaris) 		5 / 12 ALA A  12
VAL A 131
ALA A 147
ASP A 146
PHE A 112
 None
 1.02A 4qrcA-3hu5A:
undetectable		 4qrcA-3hu5A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3hu5 ISOCHORISMATASE
FAMILY PROTEIN
(Desulfovibrio
vulgaris) 		6 / 12 VAL A  56
ALA A  12
VAL A 131
ALA A  10
ALA A 147
ASP A 146
 None
 1.22A 4v04A-3hu5A:
undetectable		 4v04A-3hu5A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3hu5 ISOCHORISMATASE
FAMILY PROTEIN
(Desulfovibrio
vulgaris) 		6 / 12 ALA A  12
VAL A 131
ALA A  10
ALA A 147
ASP A 146
PHE A 112
 None
 1.26A 4v04B-3hu5A:
undetectable		 4v04B-3hu5A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_1
(CYTOCHROME P450 2D6)		 3hu5 ISOCHORISMATASE
FAMILY PROTEIN
(Desulfovibrio
vulgaris) 		5 / 12 GLY A  41
LEU A  42
ASP A 190
VAL A 157
VAL A   9
 None
 0.97A 4wnwB-3hu5A:
undetectable		 4wnwB-3hu5A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 3hu5 ISOCHORISMATASE
FAMILY PROTEIN
(Desulfovibrio
vulgaris) 		5 / 12 PRO A  37
THR A  35
GLY A  41
ALA A  46
ARG A  47
 None
 0.95A 5c0oG-3hu5A:
3.8		 5c0oG-3hu5A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_H_BO2H306_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)		 3hu5 ISOCHORISMATASE
FAMILY PROTEIN
(Desulfovibrio
vulgaris) 		5 / 10 THR A  35
GLU A 170
ALA A  32
GLY A  31
ALA A 163
 None
 1.15A 5lf3H-3hu5A:
undetectable
5lf3I-3hu5A:
undetectable		 5lf3H-3hu5A:
21.48
5lf3I-3hu5A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_V_BO2V303_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)		 3hu5 ISOCHORISMATASE
FAMILY PROTEIN
(Desulfovibrio
vulgaris) 		5 / 10 THR A  35
GLU A 170
ALA A  32
GLY A  31
ALA A 163
 None
 1.15A 5lf3V-3hu5A:
undetectable
5lf3W-3hu5A:
undetectable		 5lf3V-3hu5A:
21.48
5lf3W-3hu5A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_H_6V8H305_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		 3hu5 ISOCHORISMATASE
FAMILY PROTEIN
(Desulfovibrio
vulgaris) 		5 / 11 THR A  35
GLU A 170
ALA A  32
GLY A  31
ALA A 163
 None
 1.13A 5lf7H-3hu5A:
undetectable
5lf7I-3hu5A:
undetectable		 5lf7H-3hu5A:
21.48
5lf7I-3hu5A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_V_6V8V303_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		 3hu5 ISOCHORISMATASE
FAMILY PROTEIN
(Desulfovibrio
vulgaris) 		5 / 11 THR A  35
GLU A 170
ALA A  32
GLY A  31
ALA A 163
 None
 1.12A 5lf7V-3hu5A:
undetectable
5lf7W-3hu5A:
undetectable		 5lf7V-3hu5A:
21.48
5lf7W-3hu5A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3hu5 ISOCHORISMATASE
FAMILY PROTEIN
(Desulfovibrio
vulgaris) 		3 / 3 PHE A 148
ASP A 153
LEU A  54
 None
 0.75A 5uhbC-3hu5A:
undetectable		 5uhbC-3hu5A:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		 3hu5 ISOCHORISMATASE
FAMILY PROTEIN
(Desulfovibrio
vulgaris) 		5 / 12 GLY A  88
VAL A  92
GLY A  64
ASP A  66
ASP A  15
 None
 0.94A 6gngA-3hu5A:
5.3		 6gngA-3hu5A:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		 3hu5 ISOCHORISMATASE
FAMILY PROTEIN
(Desulfovibrio
vulgaris) 		5 / 12 THR A  86
GLY A  88
VAL A  92
GLY A  64
ASP A  66
 None
 1.19A 6gngA-3hu5A:
5.3		 6gngA-3hu5A:
15.72