SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hug'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3hug PROBABLE CONSERVED
MEMBRANE PROTEIN
(Mycobacterium
tuberculosis) 		4 / 7 TYR B  34
GLY B  59
ALA B  60
LEU B  64
 None
 0.82A 2wekB-3hugB:
undetectable		 2wekB-3hugB:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_0
(UNCHARACTERIZED
PROTEIN RPA2492)		 3hug RNA POLYMERASE SIGMA
FACTOR
PROBABLE CONSERVED
MEMBRANE PROTEIN
(Mycobacterium
tuberculosis;
Mycobacterium
tuberculosis) 		5 / 12 TYR A 135
GLY B  37
GLY A 138
SER A 134
LEU B  36
 None
 1.19A 3e23A-3hugA:
undetectable		 3e23A-3hugA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3hug RNA POLYMERASE SIGMA
FACTOR
(Mycobacterium
tuberculosis) 		4 / 7 GLY A 149
ASP A 147
ILE A 144
VAL A 155
 None
 0.81A 3fi0E-3hugA:
undetectable		 3fi0E-3hugA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_I_TRPI1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3hug RNA POLYMERASE SIGMA
FACTOR
(Mycobacterium
tuberculosis) 		4 / 8 GLY A 149
ASP A 147
ILE A 144
VAL A 155
 None
 0.76A 3fi0I-3hugA:
undetectable		 3fi0I-3hugA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_B_REAB601_1
(RETINOIC ACID
RECEPTOR)		 3hug PROBABLE CONSERVED
MEMBRANE PROTEIN
RNA POLYMERASE SIGMA
FACTOR
(Mycobacterium
tuberculosis) 		5 / 10 VAL B  67
LEU B  70
LEU A 123
ARG A 164
VAL A 163
 None
 1.19A 6eu9B-3hugB:
undetectable		 6eu9B-3hugB:
21.36