SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hul'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_B_TESB904_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 3hul HOMOSERINE KINASE
(Listeria
monocytogenes) 		4 / 7 TYR A 145
VAL A  92
ILE A  95
GLU A 109
 None
 0.95A 1j96B-3hulA:
undetectable		 1j96B-3hulA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 3hul HOMOSERINE KINASE
(Listeria
monocytogenes) 		4 / 6 ARG A 229
ASP A 123
ASN A 124
GLU A 209
 None
None
SO4  A 297 ( 4.7A)
None
 1.29A 1rjdA-3hulA:
undetectable		 1rjdA-3hulA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 3hul HOMOSERINE KINASE
(Listeria
monocytogenes) 		4 / 6 ARG A 229
ASP A 123
ASN A 124
GLU A 209
 None
None
SO4  A 297 ( 4.7A)
None
 1.27A 1rjdB-3hulA:
undetectable		 1rjdB-3hulA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 3hul HOMOSERINE KINASE
(Listeria
monocytogenes) 		4 / 6 ARG A 229
ASP A 123
ASN A 124
GLU A 209
 None
None
SO4  A 297 ( 4.7A)
None
 1.21A 1rjdC-3hulA:
undetectable		 1rjdC-3hulA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WM3_A_NFLA1301_1
(NMRA-LIKE FAMILY
DOMAIN CONTAINING
PROTEIN 1)		 3hul HOMOSERINE KINASE
(Listeria
monocytogenes) 		4 / 6 LEU A  25
THR A  24
LEU A 276
ASP A 273
 None
 1.07A 2wm3A-3hulA:
undetectable		 2wm3A-3hulA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_A_CL6A506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3hul HOMOSERINE KINASE
(Listeria
monocytogenes) 		5 / 9 VAL A 129
LEU A  63
ILE A 114
ALA A 115
ALA A  98
 None
 1.14A 3mdvA-3hulA:
undetectable		 3mdvA-3hulA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		 3hul HOMOSERINE KINASE
(Listeria
monocytogenes) 		5 / 10 ILE A 159
THR A 248
GLY A  83
GLY A  85
SER A  86
 None
None
SO4  A 297 (-3.4A)
SO4  A 297 (-3.3A)
SO4  A 297 (-4.6A)
 1.09A 4bwlC-3hulA:
undetectable		 4bwlC-3hulA:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_A_CAMA1419_0
(CYTOCHROME P450)		 3hul HOMOSERINE KINASE
(Listeria
monocytogenes) 		4 / 8 LEU A  29
LEU A  97
GLY A  94
THR A  59
 None
 0.81A 4c9nA-3hulA:
undetectable		 4c9nA-3hulA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OU1_A_BEZA302_0
(RETRO-ALDOLASE,
DESIGN RA114)		 3hul HOMOSERINE KINASE
(Listeria
monocytogenes) 		4 / 8 ILE A 114
LYS A 111
ASN A  99
ALA A  98
 None
 0.94A 4ou1A-3hulA:
undetectable		 4ou1A-3hulA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H8T_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 3hul HOMOSERINE KINASE
(Listeria
monocytogenes) 		5 / 12 LEU A 265
ILE A 196
TYR A 238
MET A 201
LEU A  21
 None
 1.09A 5h8tA-3hulA:
undetectable		 5h8tA-3hulA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_A_NIZA807_1
(CATALASE-PEROXIDASE)		 3hul HOMOSERINE KINASE
(Listeria
monocytogenes) 		4 / 8 GLU A 163
GLY A 246
LEU A 242
THR A 248
 None
 0.98A 5sxtA-3hulA:
undetectable		 5sxtA-3hulA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3hul HOMOSERINE KINASE
(Listeria
monocytogenes) 		3 / 3 PHE A 158
ASP A 273
LEU A 164
 None
 0.75A 5uhbC-3hulA:
undetectable		 5uhbC-3hulA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3hul HOMOSERINE KINASE
(Listeria
monocytogenes) 		3 / 3 PHE A 158
ASP A 273
LEU A 164
 None
 0.75A 5uhcC-3hulA:
undetectable		 5uhcC-3hulA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3hul HOMOSERINE KINASE
(Listeria
monocytogenes) 		5 / 10 SER A 219
LEU A  84
SER A 243
ILE A 159
PRO A 160
 None
 1.42A 6dlzB-3hulA:
undetectable
6dlzC-3hulA:
undetectable		 6dlzB-3hulA:
13.45
6dlzC-3hulA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3hul HOMOSERINE KINASE
(Listeria
monocytogenes) 		5 / 11 ILE A 159
PRO A 160
SER A 219
LEU A  84
SER A 243
 None
 1.41A 6dlzA-3hulA:
undetectable
6dlzD-3hulA:
undetectable		 6dlzA-3hulA:
13.45
6dlzD-3hulA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3hul HOMOSERINE KINASE
(Listeria
monocytogenes) 		5 / 10 SER A 219
LEU A  84
SER A 243
ILE A 159
PRO A 160
 None
 1.41A 6dm1B-3hulA:
undetectable
6dm1C-3hulA:
undetectable		 6dm1B-3hulA:
13.45
6dm1C-3hulA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3hul HOMOSERINE KINASE
(Listeria
monocytogenes) 		5 / 11 ILE A 159
PRO A 160
SER A 219
LEU A  84
SER A 243
 None
 1.41A 6dm1A-3hulA:
undetectable
6dm1D-3hulA:
undetectable		 6dm1A-3hulA:
13.45
6dm1D-3hulA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3hul HOMOSERINE KINASE
(Listeria
monocytogenes) 		5 / 10 SER A 219
LEU A  84
SER A 243
ILE A 159
PRO A 160
 None
 1.46A 6dm2B-3hulA:
undetectable
6dm2C-3hulA:
undetectable		 6dm2B-3hulA:
13.45
6dm2C-3hulA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3hul HOMOSERINE KINASE
(Listeria
monocytogenes) 		5 / 10 ILE A 159
PRO A 160
SER A 219
LEU A  84
SER A 243
 None
 1.46A 6dm2A-3hulA:
undetectable
6dm2D-3hulA:
undetectable		 6dm2A-3hulA:
13.45
6dm2D-3hulA:
13.45