SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hut'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 3hut PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER
(Rhodospirillum
rubrum) 		5 / 12 GLU A 200
GLY A 204
GLY A 203
VAL A 206
GLY A 163
 None
 0.88A 1n2xB-3hutA:
4.7		 1n2xB-3hutA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3hut PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER
(Rhodospirillum
rubrum) 		5 / 12 GLY A 111
LEU A  43
LEU A 113
GLY A 323
ALA A 327
 None
 1.08A 2bm9F-3hutA:
3.9		 2bm9F-3hutA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3hut PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER
(Rhodospirillum
rubrum) 		5 / 12 MET A 238
ALA A 237
VAL A 259
GLY A 182
ILE A 181
 None
 1.02A 2dcfA-3hutA:
undetectable		 2dcfA-3hutA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 3hut PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER
(Rhodospirillum
rubrum) 		5 / 11 GLN A  95
ALA A  96
ALA A  52
GLY A  51
THR A  50
 None
 0.99A 2f16H-3hutA:
undetectable
2f16I-3hutA:
undetectable		 2f16H-3hutA:
21.36
2f16I-3hutA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 3hut PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER
(Rhodospirillum
rubrum) 		5 / 11 GLN A  95
ALA A  96
ALA A  52
GLY A  51
THR A  50
 None
 0.99A 2f16V-3hutA:
undetectable
2f16W-3hutA:
undetectable		 2f16V-3hutA:
21.36
2f16W-3hutA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_B_017B203_1
(HIV-1 PROTEASE)		 3hut PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER
(Rhodospirillum
rubrum) 		4 / 7 GLU A 335
PRO A  81
ARG A  80
GLY A 333
 None
 1.21A 2hs1B-3hutA:
undetectable		 2hs1B-3hutA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_C_TPFC2471_1
(CYTOCHROME P450 121)		 3hut PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER
(Rhodospirillum
rubrum) 		4 / 8 THR A 355
VAL A 354
VAL A 300
ALA A  63
 None
 0.93A 2ij7C-3hutA:
undetectable		 2ij7C-3hutA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_4
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 3hut PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER
(Rhodospirillum
rubrum) 		5 / 5 ALA A 140
ALA A  96
ALA A 100
GLN A 152
VAL A 112
 None
 1.45A 2nyrB-3hutA:
3.2		 2nyrB-3hutA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OA1_B_ADNB2005_1
(TRYPTOPHAN
HALOGENASE)		 3hut PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER
(Rhodospirillum
rubrum) 		4 / 7 GLY A  76
GLY A  75
VAL A 329
LEU A  41
 None
 0.80A 2oa1B-3hutA:
3.7		 2oa1B-3hutA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_C_ACTC36_0
(GCN4 LEUCINE ZIPPER)		 3hut PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER
(Rhodospirillum
rubrum) 		5 / 10 ALA A  93
ALA A 124
GLU A  46
ALA A  96
SER A  89
 None
 1.31A 2r2vC-3hutA:
undetectable
2r2vF-3hutA:
undetectable
2r2vG-3hutA:
undetectable		 2r2vC-3hutA:
6.65
2r2vF-3hutA:
6.65
2r2vG-3hutA:
6.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM9_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3hut PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER
(Rhodospirillum
rubrum) 		4 / 8 MET A 238
ALA A 237
GLY A 182
ILE A 181
 None
 0.90A 2zm9A-3hutA:
undetectable		 2zm9A-3hutA:
25.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3hut PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER
(Rhodospirillum
rubrum) 		5 / 5 PRO A 311
VAL A 300
THR A 358
GLY A 356
LYS A 369
 None
 1.46A 3elzB-3hutA:
undetectable		 3elzB-3hutA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 3hut PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER
(Rhodospirillum
rubrum) 		5 / 12 GLU A 162
GLY A 188
VAL A 178
GLY A 261
SER A 263
 None
 1.29A 3k13A-3hutA:
2.6		 3k13A-3hutA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3hut PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER
(Rhodospirillum
rubrum) 		4 / 6 ILE A 324
ALA A 321
ALA A 316
THR A 355
 None
 1.06A 3mdrB-3hutA:
undetectable		 3mdrB-3hutA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3hut PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER
(Rhodospirillum
rubrum) 		5 / 12 GLY A 163
GLY A 261
SER A 262
ALA A 168
TRP A 169
 None
 1.12A 3ou6B-3hutA:
undetectable		 3ou6B-3hutA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_B_ADNB301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 3hut PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER
(Rhodospirillum
rubrum) 		5 / 10 ALA A 321
GLY A 323
LEU A 113
LEU A 326
ILE A  84
 None
 1.00A 3wdmB-3hutA:
undetectable		 3wdmB-3hutA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_B_ADNB301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 3hut PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER
(Rhodospirillum
rubrum) 		5 / 10 ALA A 328
ARG A 331
GLY A 330
LEU A  43
LEU A 341
 None
 1.08A 3wdmB-3hutA:
undetectable		 3wdmB-3hutA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_C_ADNC301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 3hut PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER
(Rhodospirillum
rubrum) 		5 / 9 ALA A 321
GLY A 323
LEU A 113
LEU A 326
ILE A  84
 None
 1.06A 3wdmC-3hutA:
3.3		 3wdmC-3hutA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_D_ADND301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 3hut PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER
(Rhodospirillum
rubrum) 		5 / 10 ALA A 321
GLY A 323
LEU A 113
LEU A 326
ILE A  84
 None
 0.96A 3wdmD-3hutA:
undetectable		 3wdmD-3hutA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_D_ADND301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 3hut PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER
(Rhodospirillum
rubrum) 		5 / 10 ALA A 328
ARG A 331
GLY A 330
LEU A  43
LEU A 341
 None
 1.09A 3wdmD-3hutA:
undetectable		 3wdmD-3hutA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA504_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 3hut PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER
(Rhodospirillum
rubrum) 		4 / 8 PHE A 103
GLY A  44
LEU A  85
ILE A  84
 None
 0.87A 4em2A-3hutA:
undetectable		 4em2A-3hutA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3hut PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER
(Rhodospirillum
rubrum) 		3 / 3 ILE A 384
ASP A 173
ARG A 377
 None
 0.69A 4pstA-3hutA:
undetectable		 4pstA-3hutA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN)		 3hut PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER
(Rhodospirillum
rubrum) 		5 / 12 ALA A 192
GLY A 188
ALA A 284
GLY A 261
TYR A 235
 None
 1.19A 4r29A-3hutA:
undetectable		 4r29A-3hutA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_0
(HYDG PROTEIN)		 3hut PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER
(Rhodospirillum
rubrum) 		5 / 12 TYR A 307
VAL A 322
LEU A  47
ALA A 302
PHE A 299
 None
 1.35A 4rtbA-3hutA:
undetectable		 4rtbA-3hutA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_B_PZAB1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 3hut PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER
(Rhodospirillum
rubrum) 		5 / 7 ASN A 209
VAL A 180
ALA A 237
GLY A 188
ARG A 196
 None
 1.34A 5fpdB-3hutA:
undetectable		 5fpdB-3hutA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_0
(METHYLTRANSFERASE)		 3hut PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER
(Rhodospirillum
rubrum) 		5 / 12 ALA A 233
VAL A 178
GLY A 261
ALA A 264
PHE A 195
 None
 1.01A 5n5dA-3hutA:
4.9		 5n5dA-3hutA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_F_CCSF14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 3hut PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER
(Rhodospirillum
rubrum) 		4 / 6 PHE A 116
LEU A  47
SER A 121
GLY A 114
 None
 1.00A 5o4yF-3hutA:
undetectable		 5o4yF-3hutA:
5.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 3hut PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER
(Rhodospirillum
rubrum) 		5 / 12 LEU A 326
VAL A 322
ALA A 155
ALA A 321
GLY A 318
 None
 1.21A 5tzoB-3hutA:
undetectable		 5tzoB-3hutA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_A_9KLA402_0
(EST-Y29)		 3hut PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER
(Rhodospirillum
rubrum) 		5 / 12 TYR A 351
LEU A 136
GLY A 330
ALA A 328
LEU A 341
 None
 1.06A 5zwrA-3hutA:
undetectable		 5zwrA-3hutA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPL_B_PA1B605_1
(LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA)		 3hut PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER
(Rhodospirillum
rubrum) 		3 / 3 ARG A 377
ARG A 251
ARG A 282
 None
 1.02A 6bplA-3hutA:
undetectable
6bplB-3hutA:
undetectable		 6bplA-3hutA:
13.95
6bplB-3hutA:
13.95